Curriculum Vitae
Wamdy Beatty



PubMed Publications: for beatty + WL

Office Address: Department of Molecular Microbiology
Center for Infectious Disease Research
Washington University School of Medicine
660 South Euclid Avenue, Campus Box 8230
St. Louis, MO. 63110-1093
Lab:  10302 McDonnell Pediatric Research Building
Tel:  314-362-4987
Fax:  314-362-1232
Email: beatty [at] wusm.wustl.edu
   

Education:

1988 in Microbiology, Montana State University, Bozeman
1994 PhD in Medical Microbiology and Immunology, University of Wisconsin, Madison

Research Experience:

1989-1994 Graduate Research Assistant in the lab of Gerald I. Byrne, Dept. of Medical Microbiology and Immunology, University of Wisconsin, Madison, Wiscons
1994-1996 1994-1996 Postdoctoral Scientist in the lab of Philippe J. Sansonetti, Unité de Pathogénie Microbienne Moléculaire, Institut Pasteur, Paris, France
1997-2000 1997-2000 Postdoctoral Scientist in the lab of David G. Russell, Dept. of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri
2000-2006 Research Instructor/Director of the Molecular Microbiology Imaging Facility, Washington University School of Medicine, St. Louis, Missouri
2007-present Research Assistant Professor and Director of Molecular Microbiology Imaging Facility Washington University School of Medicine, St. Louis, Missouri

Research Fellowships/Awards:

1994-1996 Institut National de la Santé et de la Recherche Médicale, France
1994 Sigma-Xi Research Dissertation Award, University of Wisconsin

Publications:

  1. Gordon, J.L., W.L. Beatty, L.D. Sibley.  2008 A novel actin-related protein is associated with daughter cell formation in Toxoplasma. Eukaryotic Cell.  Published online ahead of print 11 April 2008.
  2. Jani D., R.Nagarkatt, W. Beatty, R. Angel, C. Slebodnick, J. Anderson, S. Kumar, and D. Rathore.  2008. HDP—A Novel Heme Detoxification Protein from the Malaria Parasite.  PLoS Pathogens 4:e1000053.
  3. Beatty W.L.  2008. Late endocytic multivesicular bodies intersect the chlamydial inclusion in the absence of CD63.  Infection and Immunity.  76:2872-2881.
  4. Brossier, F., G.L. Starnes, W.L. Beatty, L.D. Sibley.  2008. Microneme rhomboid protease TgROM1 is required for efficient intracellular growth of Toxoplasma gondii.  Eukaryotic Cell.  7:664-674. Nagamune K., W.L. Beatty, L.D. Sibley.  2007.  Artemisinin induces calcium-dependent protein secretion in the protozoan parasite Toxoplasma gondii.  Eukaryotic Cell.  6:2147-2156.
  5. Beatty, W.L.  2007.  Lysosome repair enables host cell survival and bacterial persistence following Chlamydia trachomatis infection.  Cellular Microbiology.  9:2141-2152.
  6. Taylor, S., A. Barragan, C. Su, B. Fux, S.J. Fentress, K. Tang, W.L. Beatty, H.E. Hajj, M. Jerome, M.S. Behnke, M. White, J.C. Wootton, L.D. Sibley.  2006  A secreted serine-threonine kinase determines virulence in the eukaryotic pathogen Toxoplasma gondii.  Science.  314:1776-1780.
  7. Beatty W.L.  2006  Trafficking from CD63-positive late endocytic multivesicular bodies is essential for intracellular development of Chlamydia trachomatis.  Journal of Cell Science.  119:350-359.
  8. Sahoo N., W. Beatty, J. Heuser, D. Sept, L.D. Sibley.  2006.  Unusual kinetic and structural properties control rapid assembly and turnover of actin in the parasite Toxoplasma gondii.  Molecular Biology of the Cell. 17:895-906.
  9. Klemba, M., W. Beatty, I. Gluzman, and D. Goldberg.  2004.  Trafficking of plasmepsin II to the food vacuole of the malaria parasite.  Journal of Cell Biology. 164:47-56.
  10. Belland, R.J., D.E. Nelson, D. Virok, D.D. Crane, D. Hogan, D. Sturdevant, W.L. Beatty, and H.D. Caldwell.  2003.  Transcriptome analysis of chlamydial growth during IFN-g-mediated persistence and reactivation.  Proceedings of the National Academy of Sciences USA.  100:8478-8483.
  11. Belland, R.J., G. Zhong, D.D. Crane, D. Hogan, D. Sturdevant, J. Sharma, W.L. Beatty, and H.D. Caldwell.  2003. Genomic transcriptional profiling of the developmental cycle of Chlamydia trachomatis.  Proceedings of the National Academy of Sciences USA.  100:8478-8483.
  12. Huynh, M.H., K.E. Rabenau, J.M. Harper, W.L. Beatty, L.D. Sibley, V.B. Carruthers.  2003. Rapid invasion of host cells by Toxoplasma requires secretion of the MIC2-M2AP adhesive protein complex.  EMBO Journal 22:2082-2090.
  13. Hahn, D.L., A.A. Azenabor, W. L. Beatty, and G.I. Byrne.  2002. Chlamydia pneumoniae as a respiratory pathogen.  Frontiers in Bioscience.  7:e66-76.
  14. Banerjee, R., J. Liu, W. Beatty, L. Pelosof, M. Klemba, and D.E. Goldberg. 2002. Four plasmepsins are active in the Plasmodium falciparum food vacuole, including a protease with an active-site histidine.  Proceedings of the National Academy of Sciences USA.  99:990-995.
  15. Beatty, W.L. E.R. Rhoades, D.K. Hsu, F.-T. Liu, and D.G. Russell. 2002. Association of a macrophage galactoside-binding protein with Mycobacterium-containing phagosomes. Cellular Microbiology. 4:167-176.
  16. Byrne, G.I., S.P. Oullette, J.P. Rao, L. Lu, W.L. Beatty, and A.P. Hudson. 2001. Chlamydia pneumoniae expresses genes required for DNA replication but not cytokinesis during persistent infection of Hep-2 cells. Infection and Immunity. 69:5423-5429.
  17. Beatty, W.L., H.-J. Ullrich, and D.G. Russell.  2001. Mycobacterial surface moieties are released from infected macrophages by a constitutive exocytic event.  European Journal of Cell Biology.  80:31-40.
  18. Ullrich, H.-J., W.L. Beatty, and D.G. Russell.  2000. Interaction of Mycobacterium avium-containing phagosomes with the antigen presentation pathway. Journal of Immunology.  165:6073-6080.
  19. Beatty, W.L. and D.G. Russell. 2000. Identification of mycobacterial surface proteins released into subcellular compartments of infected macrophages. Infection and Immunity. 68:6997-7002.
  20. Beatty, W.L., E.R. Rhoades, H.-J. Ullrich, D. Chatterjee, J.E. Heuser, and D.G. Russell.   2000.  Trafficking of mycobacterial lipids in infected macrophages.  Traffic.  1:235-247.
  21. Ullrich, H.-J., W.L. Beatty, and D.G. Russell. 1999. Direct delivery of procathepsin D to phagosomes: Implications for phagosome biogenesis and parasitism by Mycobacterium.  European Journal of Cell Biology.  78:739-748.
  22. Beatty, W.L. and D.G. Russell. 1999. Analysis of Mycobacterium-infected macrophages by immunoelectron microscopy and cell fractionation.  In Mycobacteria Protocols. ed. T. Parish and N.G. Stoker.  (Humana Press, Totowa, New Jersey).
  23. Russell, D.G., D.G. Mordue, W.L. Beatty, O.K. Giddings, J.L. Lovett, A. Lingnau, M. Lingnau, J. Dant, and L.D. Sibley. 1999. Cell biological approaches to the study of intracellular pathogens: motility, invasion, secretion and vesicular trafficking. 
  24. Beatty, W.L., S. Méresse, P. Gounon, J. Davoust, J. Mounier, P.J. Sansonetti, and J.-P. Gorvel. 1999. Trafficking of Shigella lipopolysaccharide in polarized intestinal epithelial cells.  Journal of Cell Biology.  145:689-698.
  25. Beatty, W.L. and P.J. Sansonetti. 1997. Role of lipopolysaccharide in signaling subepithelial polymorphonuclear leukocytes.  Infection and Immunity.  65:4395-4404.
  26. Beatty, W.L., R.P. Morrison, and G.I. Byrne. 1995. Reactivation of persistent Chlamydia trachomatis infection in cell culture.  Infection and Immunity.  63:199-205.
  27. Beatty, W.L., T.A. Belanger, A.A. Desai, R.P. Morrison, and G.I. Byrne. 1994. Tryptophan depletion as a mechanism of gamma interferon mediated chlamydial persistence.  Infection and Immunity.  62:3705-3711.
  28. Beatty, W.L., R.P. Morrison, and G.I. Byrne. 1994. Immunoelectron microscopic quantitation of differential levels of chlamydial proteins in a cell culture model for persistent Chlamydia trachomatis infection.  Infection and Immunity.  62:4059-4062.
  29. Beatty, W.L., T.A. Belanger, A.A. Desai, R.P. Morrison, and G.I. Byrne. 1994. Role of tryptophan in gamma interferon-mediated chlamydial persistence.  Annals of the New York Academy of Sciences, USA.  730:304-306.
  30. Beatty, W.L., G.I. Byrne, and R.P. Morrison. 1994. Persistent Chlamydia and chlamydial disease:  From cell culture to a paradigm for chlamydial pathogenesis.  Microbiological Reviews.  58:686-699.
  31. Beatty, W.L., G.I. Byrne, and R.P. Morrison.  1994. Repeated and persistent infection with Chlamydia and the development of chronic inflammation and disease.  Trends in Microbiology.  2:94-98.
  32. Beatty, W.L., G.I. Byrne, and R.P. Morrison. 1994. ‘Persistent’ forms and persistence of Chlamydia.   (response) Trends in Microbiology.  2:258-259.
  33. Beatty, W.L., T.A. Belinger, K.D. Le, A.A. Desai, R.P. Morrison, and G.I. Byrne. 1994. Chlamydial persistence: Mechanism of induction and parallels to a stress-related response.  In Chlamydial Infections. (Societa Editrice Esculapio, Bologna, Italy)  pp.415-418.
  34. Beatty, W.L., G.I. Byrne, and R.P. Morrison. 1993. Morphological and antigenic characterization of interferon-g mediated persistent Chlamydia trachomatis infection in vitro.  Proceedings of the National Academy of Sciences USA.  90:3998-4002.
  35. Byrne, G.I., W.L. Beatty, and C.S. Shobert. 1992. Cytokine-mediated antimicrobial events:  mechanism of  action.  In Cytokines and resistance to nonviral pathogenic infections. (Biomedical Press, Augusta, Georgia)  pp. 169-176.
  36. Brawner, D.L., J.E. Cutler, and W. Beatty. 1990. Caveats in the investigation of form-specific molecules of Candida  albicans.  Infection and Immunity.  58:378-383.

Research Support:

American Heart Association 01/01/2009 – 12/31/2010
Mechanism of cholesterol acquisition by Chlamydia

Editorial Experience:

Ad-hoc reviewer:
Infection and Immunity
Cellular Microbiology
FEMS Immunology and Medical Microbiology
BMC Microbiology
Microbial Pathogenesis