Curriculum Vitae
Deborah E. Dobson


PubMed Publications: for dobson + DE

Office Address: Departments of Molecular Microbiology
Washington University School of Medicine
9240 McDonnell Pediatric Research Building
Campus Box 8230
660 S. Euclid Ave.
St. Louis, MO 63110
Phone, office: 314-747-2631
FAX: 314-747-2634
Email: ddobson [at] wusm.wustl.edu
   

 

 

Education:

June 1981 Ph. D.: Department of Biochemistry, University of California, Berkeley, Allan C. Wilson, thesis advisor
May 1976 B.S.: University of Illinois, Urbana, Honors in Biochemistry

Academic Positions:

1997-present Research Associate Professor of Molecular Microbiology, Washington University School of Medicine
Host-parasite interactions, developmental gene regulation in Leishmania major.
1988-1997 Assistant Professor of Biochemistry, Boston University School of Medicine; Cancer Research Center member; Center for Human Genetics member.
Developmental gene regulation in fat and skeletal muscle cells, basis for age-related decline in preadipocyte differentiation potential.
1983-1988 Postdoctoral Research fellow, Division of Cell and Molecular Biology, Dana-Farber Cancer Institute and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School (with B. M. Spiegelman).
Adipocyte gene regulation, novel angiogenesis factors secreted by adipocytes
1981-1983 American Cancer Society Research fellow, Department of Pharmacology, Stanford University Medical School (with G. M. Ringold).
Hormonal regulation of viral gene expression.

Honors and Awards:

   
Post-Graduate  
1992-1997

NIH Program Project grant

1990-1991 Boston University School of Medicine Biomedical Research Grant
1989-1990 Whitaker Health Sciences Foundation Award
1989-1990 American Cancer Society Institutional Research Seed Grant
1984-1986 Charles A. King Trust Research Fellow
1984-1985 Dana-Farber Cancer Institute Biomedical Research Grant
1981-1983 American Cancer Society Research Fellow
   
Graduate  
1976-1980 US Public Health Service predoctoral trainee
1976-1980 Winter Quarter Lecture series organizer
1979-1980 Biochemistry Graduate Student Association president
1978-1979 Teaching assistantships
   
Undergraduate  
1976 Departmental Distinction in Biochemistry
1972-1976 James Scholar honors program
  Alpha Lambda Delta scholastic honorary
  Phi Kappa Phi scholastic honorary
  Phi Lambda Upsilon chemistry honorary

 

 

Publications:

  1. Romano, A., Inbar, E., Debrabant, A., Charmoy, M., Lawyer, P., Ribeiro-Gomes, F., Barhoumi, M., Grigg, M., Shaik, J., Dobson, D.E., Beverley, S.M., and Sacks, D.L. (2014), “Cross-species Genetic Exchange between Visceral and Cutaneous strains of Leishmania in the Sand Fly Vector”, submitted to PNAS.


  2. Zangger, H., Hailu, A., Desponds, C., Lye, L-F., Akopyants, N.S., Dobson, D.E., Ronet, C., Ghalib, H., Beverley, S.M., and Fasel, N. (2014), “Leishmania aethiopica Field Isolates Bearing and Endosymbiotic dsRNA Virus Induce Pro-Inflammatory Cytokine Response”, PLoS Neglected Tropical Diseases 8:e2836.


  3. Inbar, E., Akopyants, N.S., Charmoy, M., Romano, A., Lawyer, P., Elnaiem, E.A., Kauffmann, F. Barhoumi, M., Grigg, M., Owens, K., Fay, M., Dobson, D.E., Shak, J., Beverley, S.M., and Sacks, D. (2013) “The Mating Competence of Geographically Diverse Leishmania major Strains in Their Natural and Unnatural Sand Fly Vectors”, PLoS Genetics 9: e1003672.


  4. Dobson, D.E., Kamhawi, S., Lawyer, P., Turco, S.J., Beverley, S.M., and Sacks, D.L. (2010), “Leishmania major Survival in Selective Phlebotomus papatasi Sand Fly Vector Requires a Specific SCG-encoded Lipophosphoglycan Galactosylation Pattern”, PLoS Pathogens 6: e1001185.


  5. Akopyants, N.S.+, Kimblin, N.+, Secondino, N., Patrick, R., Lawyer, P., Dobson, D.E., Beverley, S.M.*, and Sacks, D.L.* (2009), “Demonstration of genetic exchange involving meiotic division of Leishmania in the sand fly vector”, Science 324: 265-268.  (*,+ mark authors contributing equally).


  6. Capul, A.A., Barron, T., Dobson, D.E., Turco, S.J., and Beverley, S.M. (2007) “Two Functionally Divergent UDP-Gal Nucleotide Sugar Transporters Participate in Phosphoglycan Synthesis in Leishmania major”, J. Biol. Chem. 282: 14006-14017.


  7. Goswami, M., Dobson, D.E., Beverley, S.M.,and Turco, S.J.. (2006) “Demonstration by heterologous expression that the Leishmania SCA1 gene encodes an arabinopyranosyltransferase”, Glycobiology 16: 230-236.


  8. Dobson, D.E., Scholtes, L.D., Myler, P.J., Turco, S.J., and Beverley, S.M. (2006) “Genomic organization and expression of the expanded SCG/L/R gene family of Leishmania major: internal clusters and telomeric localization of SCGs mediating species-specific LPG modifications”, Mol. Biochem. Parasitol. 146: 231-241.


  9. Ivens, A.C., Peacock, C.S., Worthey, E.A., Murphy, L., Aggarwal, G., Berriman, M., Sisk, E., Rajandream, M.-A., Rita Aert3, A.A., Apostolou, Z., Attipoe, P., Bason, N., Bauser, C., Beck, A., Beverley, S.M., Bianchettin, G., Borzym, K., Bothe, G., Bruschi, C.V., Collins, M., Cadag, E., Ciarloni, L., Clayton, C., Coulson, R.M.R., Cronin, A., Cruz, A.K., Davies, R.M., Gaudenzi, J.D., Dobson, D.E., Duesterhoeft, A., Fazelina, G., Fosker, N., Frasch, A.C., Fraser, A., Fuchs, M., Gabel, C., Goble, A., Goffeau, A., Harris, D., Hertz-Fowler, C., Hilbert, H., Horn, D., Huang, Y., Klages, S., Knights, A., Kube, M., Larke, N., Litvin, L., Lord, A., Louie, T., Marra, M., Masuy, D., Matthews, K., Michaeli, S., Mottram, J.C., Müller-Auer, S., Munden, H., Nelson, S., Norbertczak, H., Oliver, K., O'Neil, S., Pentony, M., Pohl, T.M., Price, C., Purnelle, B., Quail, M.A., Rabbinowitsch, E., Reinhardt, R., Rieger, M., Rinta, J., Robben, J., Robertson, L., Ruiz, J.C., Rutter, S., Saunders, D., Schäfer, M., Schein, J., Schwartz, D.C., Seeger, K., Seyler, A., Sharp, S., Shin, H., Sivam, D., Squares, R., Squares, S., Tosato, V., Vogt, C., Volckaert, G., Wambutt, R., Warren, T., Wedler, H., Woodward, J., Zhou, S., Zimmermann, W., Smith, D.F., Blackwell, J.M., Stuart, K.D., Barrell, B. and Myler, P.J. (2005) “The genome of the Kinetoplastid parasite, Leishmania major”, Science 309: 436-442.


  10. Beverley, S.M. and Dobson, D.E. (2004) “Flypaper for Parasites” Cell 119: 311-312.


  11. Dobson, D.E., Mengeling, B.J., Cilmi, S.C., Turco, S.J., and Beverley, S.M. (2003) “Identification of genes encoding Arabinosyltransferases (SCA) mediating Developmental Modifications of Lipophosphoglycan (LPG) required for Sand Fly Transmission of Leishmania major”; J. Biol. Chem. 278: 28840-28848.


  12. Dobson, D.E., Scholtes, L.D., Valdez, K.E., Sullivan, D.R., Mengeling, B.J., Cilmi, S.C., Turco, S.J., and Beverley, S.M.  (2003)  “Functional Identification of Galactosyltransferases (SCGs) required for Species-specific Modifications of the Lipophosphoglycan adhesin controlling Leishmania major-Sand Fly Interactions”, J. Biol. Chem. 278: 15523-15531. 

  13.  
    Myler, P. J, Beverley, S. M., Cruz, A. K., Dobson, D. E., Ivens, A. C.,McDonagh, P. D., Madhubala, R., Martinez-Calvillo, S., Ruiz, J. C., Saxena, A., Sisk, E., Sunkin, S. M., Worthey, E., Yan, S., and Stuart, K. D. (2001) “The Leishmania genome project: new insights into gene organization and function”, Med. Microbiol. Immunol. 190: 9-12.


  14. Karagiannides, I., Tchkonia, T., Dobson, D.E., Steppan, C.M., Cummins, P., Chan, G., Salvatori, K., Hadzopoulou-Cladaras, M., and Kirkland, J.L (2001) “Altered Expression of C/EBP Family Members results in Decreased Adipogenesis with Aging”, Am. J. Physiol. Regul. Integr. Comp. Physiol. 280: R1772-80.


  15. Chakkalath, H.R., Siddiqui, A.A., Shankar, A.H., Dobson, D.E., Beverley, S.M., and Titus, R.G. (2000) “Priming of a b-Galactosidase (b-GAL)-Specific Type 1 Response in BALB/c Mice Infected with b-GAL-Transfected Leishmania major”, Infect. Immun. 68: 809-814.


  16. Garraway, L.A., Tosi, L.R., Wang, Y., Moore, J.B., Dobson, D.E., and Beverley, S.M. (1997) “Insertional Mutagenesis by a modified in vitro Ty1 Transpositional System”, Gene 198: 27 – 35.


  17. Kirkland, J.L. and Dobson, D.E. (1997) “Preadipocyte Function and Aging: Links between Age-Related Changes in Cell Dynamics and Altered Fat Tissue Function”, J. Amer. Geriatr. Soc. 45: 959-967.


  18. Dobson, D.E., Kambe, A., Block, E., Dion, T., Liu, H., Castellot, J.J., and Spiegelman, B.M. (1990) "1-butyryl glycerol:  A Novel Angiogenesis Factor secreted by Differentiating Adipocytes", Cell 61: 223-230.


  19. Dobson, D.E., Groves, D.L., and Spiegelman, B.M. (1987) "Nucleotide Sequence and Hormonal Regulation of Mouse Glycerophosphate Dehydrogenase mRNA during Adipocyte and Muscle Cell Differentiation", J. Biol. Chem. 262: 1804-1809.


  20. Hunt, C., Ro, J.H.S., Dobson, D.E., Min, H.Y., and Spiegelman, B.M. (1986) "Adipocyte P2 Gene: Developmental Expression and Homology of 5'Flanking Sequences among Fat Cell-Specific Genes", Proc. Natl. Acad. Sci. 83: 3786-3790.


  21. Castellot, J.J., Kambe, A.M., Dobson, D.E., and Spiegelman, B.M. (1986) "Heparin Potentiates Endothelial Cell Chemotaxis Stimulated by an Adipocyte-Derived Angiogenic Factor", J. Cell. Physiol. 127: 323-329.
    Dobson, D.E., Prager, E.M., and Wilson, A.C. (1984) "Stomach Lysozymes of Ruminants I. Distribution and Catalytic Properties", J. Biol. Chem. 259: 11607-11616.


  22. Jolles, P. Schoentgen, F., Jolles, J., Dobson, D.E., Prager, E.M., and Wilson, A.C. (1984) "Stomach Lysozymes of Ruminants II. Amino Acid Sequence of Cow Lysozyme 2 and Immunological Comparisons with other Lysozymes", J. Biol. Chem. 259: 11617-11625.


  23. Lee, F., Hall, C.V., Ringold, G.M., Dobson, D.E., Lun, J., and Jacob, P.E. (1984) "Functional Analysis of the Steroid Hormone Control Region of Mouse Mammary Tumor Virus", Nucleic Acids Res. 12: 4194-4206.


  24. Dobson, D.E., Lee, F., and Ringold, G.M. (1983) "Separation of Promoter and Glucocorticoid Regulatory Sequences in MMTV", in Gene Expression, UCLA Symposia on Molecular and Cellular Biology, Vol. 8, pp. 87-94, (Hamer, D. and Rosenberg, M., eds.), Alan R. Liss, Inc., New York.


  25. Ringold, G.M., Dobson, D.E., Grove, J.R., Hall, C.V., Lee, F., and Vannice, J. (1983) "Glucocorticoid Regulation of Gene Expression: Mouse Mammary Tumor Virus as a Model System", Recent Progress in Hormone Action 39: 387-424.


  26. Ringold, G.M., Chapman, A.B., Costello, M., Dobson, D.E., Hall, C.V., Grove, J.R., Lee, F., and Vannice, J. (1983) "Glucocorticoid Regulation of Mouse Mammary Tumor Virus Expression", in Biochemical Basis of Drug Action, pp. 91-106 (Singer, T.P. and Ondarza, R.N., eds.), Academic Press, New York.


  27. Dobson, D.E. (1981) “Evolution of Ruminant Lysozymes”, Ph.D. thesis, University of California, Berkeley, 149 pages.

 

Professional Service:

ad hoc reviewer for

PLoS Neglected Tropical Diseases

Molecular Microbiology

Journal of Biological Chemistry
Experimental Cell Research
Cellular Microbiology
Molecular Biology and Evolution

 

Insitut Pasteur Scientific Program for Research in Parasitic Diseases (2005).
Session Chair, Molecular Parasitology Meeting XI (2000).
NIH-HBL Institute Program Project Site Visit Team member (1991).

 

University and Departmental Service:

Washington University School of Medicine
ad hoc Interviewer for Ph.D. Admissions, Molecular Microbiology and Microbial Pathogenesis Program
ad hoc Interviewer for M.D. - Ph.D. Admissions

Boston University School of Medicine
Ph.D. Thesis Advisor for Helena Madden, Steven Perrin, and Claire Steppan
Member of Ph.D. Thesis Committee and Ph.D. Dissertation Defense Committee for 24 Biochemistry Program students, 1         Microbiology Program student, and 2 Pathology Program students (1988 - 1997)
Ad hoc Interviewer for Ph.D. Admissions, Department of Biochemistry (1988 -1997)
Ad hoc Interviewer for M.D. - Ph.D. Admissions (1988 -1997)
Co-chair, Cell and Molecular Biology Graduate Program Organizing committee. (1995 - 1997; first graduate students admitted in         1997)
Curriculum Committee, Department of Biochemistry (1988 -1992, 1996, 1997)
Ph.D. Oral Qualifying Examination and Re-examination Committees, Department of Biochemistry (1989 -1992, 1994, 1995). Student Affairs Committee, Department of Biochemistry; First Year Student Advisor (1992 -1996)
Ph.D. Written Qualifying and Examination and Re-Examination Committees, Department of Biochemistry (1993)
Medical Scientist Training Program site visit Junior Faculty representative (1989, 1993).

 

 

Teaching Responsibilities:

Washington University School of Medicine:
Course manager, Infectious Disease / Basic Microbiological Mechanisms Research Conference (2003 - 2006).
Lecturer, Bio 5392: Molecular Microbiology & Microbial Pathogenesis class (2006 - present).
Lecturer, Bio 5412: Tropical Molecular Parasitology Seminar Series & Journal Club (2004 - present).

Boston University School of Medicine:
Course Manager, GMS BI 755: Biochemistry (1996).
Course Manager, GMS BI 854: Graduate Biochemistry Seminar, Spring and Fall semesters (1990 - 1994).
Course Manager, GMS BI 751: Cell Biochemistry II-Mechanisms of Regulation (1992).
Section Manager, GMS BI 755: Biochemistry (1992 - 1994, 1996).
Lecturer, GMS BI 763: Enzymology (1990, 1992, 1994).
Lecturer, GMS BI 762: Nucleic Acids (1991, 1993).
Lecturer, GMS BI 851: Pathobiochemistry of Aging (1990).
Lecturer, GMS BI 757: Molecular Mechanisms in Growth and Development (1989).

 

Science Outreach in the Community

Member, School District of Clayton K - 12 District Science Curriculum Committee (2014 – 2016)

 

Wydown Middle School (Clayton, MO):

Infectious disease "expert" in "Da Vinci" course (advised student on presentation & position paper; participated in student's final classroom presentation).


Speaker, Career Day: “How I became a Scientist” (25 min presentation, to 4 groups of 20 sixth graders; 2013)


“Scientist at Work” lecture and laboratory experiment (genomic DNA isolation from strawberries, using “kitchen reagents”; 45 min presentation, to 4 groups of 20 6th graders; 2014)

 

Ralph M. Captain Elementary School (Clayton, MO):

Conducted “Germ Hunters” project with 60 kindergarteners (with Dr. Stephen M. Beverley; 2007)


Conducted “Art in Science” project with 60 fifth graders (with Maryellen Picker; 2007)

 

Judge and Organizing Committee member, RM Captain Elementary School Science Fair (2007 - 2011)


Assist in after-school Dissection club (fourteen 4th & 5th graders, with Chris Hwande; 2011)


Assist in after-school Bird Watchers club (ten 4th & 5th graders, with Chris Hwande; 2012)

 

 

Invited Lectures:

Molecular Parasitology Meeting XII, Woods Hole, MA (2001).
Molecular Parasitology Meeting XIII, Woods Hole, MA (2002)
Molecular Parasitology Meeting XII, Woods Hole, MA (2001).
Molecular Parasitology Meeting XI, Woods Hole, MA (2000).
Molecular Parasitology Meeting, Woods Hole, MA (1999).
Molecular Parasitology Meeting, Woods Hole, MA (1997).
Boston City Hospital, Department of Neurology (1996).
Boston University School of Medicine, Center for Human Genetics (1995).
University of Illinois, Urbana, Department of Physiology (1993).