Curriculum Vitae
Daniel E. Goldberg


PubMed Publications: for goldberg + DE
Division of Biology and Biomedical Sciences profile
Lab website: http://goldberglab.wustl.edu

Office Address: Departments of Molecular Microbiology
Washington University School of Medicine
9210 McDonnell Pediatric Research Building
Campus Box 8230
660 S. Euclid Ave.
St. Louis, MO 63110-1093
Phone, office: 314-362-1514
FAX: 314-367-3214
Email: goldberg [at] wusm.wustl.edu
   

 

 

Education:

1979 - 1985 M.D. and Ph.D., Molecular Biology (Dr. Stuart Kornfeld), Washington University, St. Louis, MO
1978 - 1979 Research Assistant, Department of Biological Chemistry, laboratory of Dr. Eugene Kennedy, Harvard Medical School, Boston, MA
1975 - 1978 A.B., Harvard College, Cambridge, MA


Current Position:

David M. and Paula L. Kipnis Distinguished Professor of Medicine and Co-chief, Division of Infectious Diseases
Professor of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO


Academic Positions and Employment:

1995-97 Associate Professor, Washington University School of Medicine
Assistant Investigator, Howard Hughes Medical Institute

1990 - 1994 Assistant Professor, Washington University School of Medicine
1988 - 1990 Research Associate,
Laboratory of Medical Biochemistry (Dr. Anthony Cerami), Rockefeller University, New York, NY
1987 - 1988 Fellow in Infectious Diseases,
Department of Medicine, Washington University School of Medicine, St. Louis, MO
1985 - 1987 Resident in Internal Medicine,
Brigham and Women's Hospital, Boston, MA

 

Bibliography:

Selected Publications:

  1. 1. Istvan ES, Mallari J, Corey V, Dharia N, Marshall G, Winzeler EA, Goldberg DE: Esterase mutation is a mechanism of resistance to antimalarial compounds. Nature Commun 2017, 8: 14240.


  2. 2. Pal P, Daniels B, Oksman A, Diamond M, Klein RS, Goldberg DE: Plasmodium falciparum histidine-rich protein II compromises brain endothelial barriers and may promote cerebral malaria pathogenesis; mBio 2016, 7: e00817-16.


  3. 3. Spillman NJ, Vaupel BA, Goldberg DE: Exported epoxide hydrolases modulate erythrocyte vasoactive lipids during Plasmodium falciparum infection. mBio 2016, 7: e01538-16.


  4. 4. Sigala PA, Morante K, Caaveiro JM, Tsumoto K, Goldberg D: In vivo enzymology to probe the catalytic activity of heme oxygenase; Biochemistry 2016, 55: 4836-4849.


  5. 5. Sigala PA, Crowley JR, Henderson JP, Goldberg DE: Deconvoluting heme biosynthesis to target blood-stage malaria parasites. eLife 2015, 4: e09143.

  6.  

  7. 6.Spillman N, Beck J, Goldberg D: Protein export into malaria parasite-infected erythrocytes: mechanisms and functional consequences; Ann Rev Biochem 2015; 84: 14.1-14.29.

    7. Beck J, Muralidharan V, Oksman A, Goldberg DE: Hsp101/PTEX mediates export of diverse malaria effector proteins into the host erythrocyte; Nature 2014, 511: 592-595.

    8. Sigala PA, Goldberg DE: Heme metabolism in Plasmodium; Ann Rev Microbiol 2014; 68: 259-278.

    9. Muralidharan V, Goldberg DE: Asparagine repeats in Plasmodium falciparum proteins. Good for nothing? PLoS Pathogens 2013; 9: e1003488.

    10. Muralidharan V, Oksman A, Goldberg DE: Heat shock protein 110 maintains the asparagine-rich proteome of Plasmodium falciparum; Nature Comm 2012; 3: 1310.

    11.Sigala PA, Crowley JR, Hsieh S, Henderson JP, Goldberg DE: Direct tests of enzymatic heme degradation by the malaria parasite Plasmodium falciparum; J Biol Chem 2012; 287: 37793-37807.

    12.Ledbetter S, Altenhofen L, Cobbold SA, Istvan ES, Fennell C, Doerig C, Llinas M, Goldberg DE: Plasmodium falciparum responds to amino acid starvation response by entering into a hibernatory state; Proc Natl Acad Sci USA 2012; E3278-3287.

    13.Goldberg DE, Siliciano RF, Jacobs WR. Outwitting evolution: fighting drug-resistant TB, malaria and HIV. Cell 2012; 148: 1271-1283.

    14.Ndonwi M, Burlingame OO, Miller AS, Tollefsen DM, Broze GJ Jr, Goldberg DE: Procoagulant effect of Plasmodium falciparum histidine-rich protein II; Blood 2011, 117: 6347-54.

    15.Muralidharan V, Oksman A, Iwamoto M, Wandless TJ, Goldberg DE: Asparagine repeat function in a Plasmodium falciparum protein assessed with a regulatable fluorescence affinity tag; Proc Natl Acad Sci USA 2011, 108: 4411-16.

    16. Istvan ES, Dharia NV, Gluzman I, Winzeler EA, Goldberg DE: Validation of isoleucine utilization targets in Plasmodium falciparum; Proc Natl Acad Sci USA 2011, 108: 1627-32.

    17. Goldberg DE, Cowman AF: Moving in and renovating: export of proteins from the Plasmodium parasite into the host erythrocyte. Nat Rev Microbiol 2010; 8: 617-621.

    18. Russo I, Babbitt S, Muralidharan V, Butler T, Oksman A, Goldberg DE: Plasmepsin V licenses Plasmodium proteins for export into the host erythrocyte; Nature 2010, 463: 632-636.


Lab Members:

Research Assistant Professor  
Eva Istvan PhD UT Southwestern
   
Post-doctoral Fellows  
Josh Beck PhD, UCLA
   
Graduate Students  
Alex Polino (PhD) BA, Cornell
Sebastian Nasamu BA, MIT
   
Undergrads  
Julia Xie  
Varun Dalmia  
   
Technicians  
Anna Oksman MS
Barb Vaupel MS
   
Post-bac  
Alex Boyko

BA, Washington U

   
Administrative Assistant  
Mary Pichler