Curriculum Vitae
Daniel E. Goldberg


PubMed Publications: for goldberg + DE
Division of Biology and Biomedical Sciences profile
Lab website: http://goldberglab.wustl.edu

Office Address: Departments of Molecular Microbiology
Washington University School of Medicine
9210 McDonnell Pediatric Research Building
Campus Box 8230
660 S. Euclid Ave.
St. Louis, MO 63110-1093
Phone, office: 314-362-1514
FAX: 314-367-3214
Email: goldberg [at] wusm.wustl.edu
   

 

 

Education:

1979 - 1985 M.D. and Ph.D., Molecular Biology (Dr. Stuart Kornfeld), Washington University, St. Louis, MO
1978 - 1979 Research Assistant, Department of Biological Chemistry, laboratory of Dr. Eugene Kennedy, Harvard Medical School, Boston, MA
1975 - 1978 A.B., Harvard College, Cambridge, MA


Current Position:

David M. and Paula L. Kipnis Distinguished Professor of Medicine and Co-chief, Division of Infectious Diseases
Professor of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO


Academic Positions and Employment:

1995-97 Associate Professor, Washington University School of Medicine
Assistant Investigator, Howard Hughes Medical Institute

1990 - 1994 Assistant Professor, Washington University School of Medicine
1988 - 1990 Research Associate,
Laboratory of Medical Biochemistry (Dr. Anthony Cerami), Rockefeller University, New York, NY
1987 - 1988 Fellow in Infectious Diseases,
Department of Medicine, Washington University School of Medicine, St. Louis, MO
1985 - 1987 Resident in Internal Medicine,
Brigham and Women's Hospital, Boston, MA

 

Bibliography:

Selected Publications:

  1.  

  1. 1. Nasamu AS, Glushakova S, Russo I, Vaupel B, Oksman A, Kim AS, Fremont D, Tolia N, Beck JR, Meyers MJ, Niles JC, Zimmerberg J, Goldberg DE: Plasmepsins IX and X are essential and druggable mediators of egress and invasion in malaria parasites, Science 2017, in press.

  2. 2. Istvan ES, Mallari J, Corey V, Dharia N, Marshall G, Winzeler EA, Goldberg DE: Esterase mutation is a mechanism of resistance to antimalarial compounds. Nature Commun 2017, 8: 14240.

    3. Pal P, Daniels B, Oksman A, Diamond M, Klein RS, Goldberg DE: Plasmodium falciparum histidine-rich protein II compromises brain endothelial barriers and may promote cerebral malaria pathogenesis; mBio 2016, 7: e00817-16.

    4. Spillman NJ, Vaupel BA, Goldberg DE: Exported epoxide hydrolases modulate erythrocyte vasoactive lipids during Plasmodium falciparum infection. mBio 2016, 7: e01538-16.

    5. Sigala PA, Morante K, Caaveiro JM, Tsumoto K, Goldberg D: In vivo enzymology to probe the catalytic activity of heme oxygenase; Biochemistry 2016, 55: 4836-4849.

    6. Sigala PA, Crowley JR, Henderson JP, Goldberg DE: Deconvoluting heme biosynthesis to target blood-stage malaria parasites. eLife 2015, 4: e09143.

    7. Spillman N, Beck J, Goldberg D: Protein export into malaria parasite-infected erythrocytes: mechanisms and functional consequences; Ann Rev Biochem 2015, 84: 14.1-14.29.

    8. Beck J, Muralidharan V, Oksman A, Goldberg DE: Hsp101/PTEX mediates export of diverse malaria effector proteins into the host erythrocyte; Nature 2014, 511: 592-595.

    9. Sigala PA, Goldberg DE: Heme metabolism in Plasmodium; Ann Rev Microbiol 2014, 68: 259-278.

    10. Muralidharan V, Goldberg DE: Asparagine repeats in Plasmodium falciparum proteins. Good for nothing? PLoS Pathogens 2013, 9: e1003488.

    11. Muralidharan V, Oksman A, Goldberg DE: Heat shock protein 110 maintains the asparagine-rich proteome of Plasmodium falciparum; Nature Comm 2012, 3: 1310.

    12. Sigala PA, Crowley JR, Hsieh S, Henderson JP, Goldberg DE: Direct tests of enzymatic heme degradation by the malaria parasite Plasmodium falciparum; J Biol Chem 2012, 287: 37793-37807.

    13. Ledbetter S, Altenhofen L, Cobbold SA, Istvan ES, Fennell C, Doerig C, Llinas M, Goldberg DE: Plasmodium falciparum responds to amino acid starvation response by entering into a hibernatory state; Proc Natl Acad Sci USA 2012; E3278-3287.

    14. Goldberg DE, Siliciano RF, Jacobs WR. Outwitting evolution: fighting drug-resistant TB, malaria and HIV. Cell 2012; 148: 1271-1283.

    15. Ndonwi M, Burlingame OO, Miller AS, Tollefsen DM, Broze GJ Jr, Goldberg DE: Procoagulant effect of Plasmodium falciparum histidine-rich protein II; Blood 2011, 117: 6347-54.

    16. Muralidharan V, Oksman A, Iwamoto M, Wandless TJ, Goldberg DE: Asparagine repeat function in a Plasmodium falciparum protein assessed with a regulatable fluorescence affinity tag; Proc Natl Acad Sci USA 2011, 108: 4411-16.

    17. Istvan ES, Dharia NV, Gluzman I, Winzeler EA, Goldberg DE: Validation of isoleucine utilization targets in Plasmodium falciparum; Proc Natl Acad Sci USA 2011, 108: 1627-32.

    18. Goldberg DE, Cowman AF: Moving in and renovating: export of proteins from the Plasmodium parasite into the host erythrocyte. Nat Rev Microbiol 2010; 8: 617-621.

    19. Russo I, Babbitt S, Muralidharan V, Butler T, Oksman A, Goldberg DE: Plasmepsin V licenses Plasmodium proteins for export into the host erythrocyte; Nature 2010, 463: 632-636.

Lab Members:

Research Assistant Professor  
Eva Istvan PhD UT Southwestern
   
Visiting Assistant Professor  
Ilaria Russo PhD U of Padua
   
Post-doctoral Fellows  
Josh Beck PhD, UCLA
   
Graduate Students  
Alex Polino (PhD) BA, Cornell
Sebastian Nasamu BA, MIT
   
Undergrads  
Yolo Avila-Cruz  
Varum Dalmia  
Laura Yang  
Courtney Barks  
   
Technicians  
Anna Oksman MS
Barb Vaupel MS
   
Post-bac  
Alex Boyko

BA, Washington U

   
Administrative Assistant  
Mary Pichler