Curriculum Vitae
Amanda L. Lewis


PubMed Publications: for LEWIS + Amanda L
Division of Biology and Biomedical Sciences profile

Office Address: Department of Molecular Microbiology
Washington University School of Medicine
9220 McDonnell Pediatric Research Building
Campus Box 8230
660 S. Euclid Ave.
St. Louis, MO 63110
Phone, office: 314-286-0016
FAX: 314-747-0264
Email: allewis [at] wustl.edu
   

 

 

Academic Appointments:

July 2009 - present Assistant Professor of Molecular Microbiology
Department of Molecular Microbiology
Washington University School of Medicine, St. Louis, MO (WUSM)
July 2011 - present Assistant Professor of Obstetrics and Gynecology
Department of Obstetrics and Gynecology
Washington University School of Medicine, St. Louis, MO (WUSM)

Education:

2006 Ph.D. -- Biological Sciences
University of California, San Diego
2001 B.S. -- Biological Sciences Minor: Biotechnology
California State Polytechnic University, San Luis Obispo

Research Experience:

2006 - 2009 Postdoctoral Researcher, Department of Pediatrics
University of California, San Diego
2001 - 2006 Graduate Student, Division of Biology
University of California, San Diego
2000 Undergraduate Intern, Iowa State University
Program for Women in Science and Engineering
1998 - 2000 Student Researcher, California Biotechnology Institute
California State Polytechnic University, San Luis Obispo, CA

Honors, Awards:

  • Basil O’Connor Research Scholar Award, March of Dimes, 2011-2013
  • University of California President’s Postdoctoral Fellowship, 2007-2009
  • A.P. Giannini Family Foundation Postdoctoral Fellowship, 2006-2007
  • Martin D. Kamen Prize for the most outstanding dissertation in biology and chemistry defended at UCSD in 2006-2007
  • Ruth L. Kirschstein (predoctoral) National Research Service Award (Institutional), 2005-2006
  • Association for Women in Science (AWIS) Scholarship, San Diego Chapter, 2005
  • National Science Foundation Predoctoral Fellowship Competition - Honorable Mention, 2002
  • California State Polytechnic University Cum Laude Graduate, 2001
  • Brandt Scholarship, Brandt Scholarship Foundation, 1996-2001
  • Waterbury Scholarship, Cal State Polytechnic University, 2000
  • Robert C. Byrd Honors Scholarship, State of CA, 1996-2000
  • Hatfield Memorial Award, Cal State Polytechnic University, 1999
  • Joe Harper Memorial Scholarship, State of CA (CCPOA), 1996-1999
  • Andrews Scholarship, Cal Poly State University, 1996

Editorial Service (Ad-Hoc Reviewer):

  • Journal of Biological Chemistry
  • Glycobiology
  • Molecular Microbiology
  • American Journal of Obstetrics and Gynecology
  • Glycobiology Insights
  • Proceedings of the National Academy of Sciences

University Service:

  • Global Health and Infectious Diseases Initiative Planning Committee, Fall 2012 - present
  • Molecular Microbiology and Microbial Pathogenesis Program Steering Committee Member, Fall 2012-present
  • Faculty Search Committee Member - Molecular Microbiology, 2012
  • Faculty Search Committee - Molecular Microbiology, Center for Women’s Infectious Disease Research, 2011
  • Retreat Organizer – WUSM Microbiology and Microbial Pathogenesis Program - 2010, 2011, 2012
  • Graduate Student Representative - UCSD Childcare Oversight Committee, 2004-2006
  • Graduate Student Representative - NSF Advance Grant Committee
         (for advancing the status of women and families at UCSD), 2005
  • Mentor - Upward Bound Program (for first-generation college students), 2002

Professional Affiliations:

LOCAL

  • Center for Women’s Infectious Disease Research
  • Digestive Diseases Research Core Center
  • Institute of Clinical and Translational Sciences

NATIONAL

  • American Society for Microbiology
  • American Society for Biochemistry and Molecular Biology
  • Society for Glycobiology
  • American Association for the Advancement of Science
  • Society for Women’s Health Research

Teaching/Mentoring Experience

Bio5392, Molecular Microbiology and Microbial Pathogenesis Graduate Course,
Division of Biology and Biomedical Sciences, Washington University in St Louis

  • Lecture: “Polymicrobial Communities in Health and Disease”
  • Mock Study Section Reviewer

 Course Instructor, Division of Biology and Biomedical Sciences, Washington University in St Louis
Bio5416  -- Current Literature in Molecular Microbiology and Microbial Pathogenesis. Spring 2011

Advisor, Intel International Science and Engineering Fair.
Provided laboratory training and project mentorship, leading to a first place entry in the San Diego Science and Engineering Fair, a fourth place entry in the Intel International Science and Engineering Fair, and manuscript in preparation. 2006-2009

Guest Lecturer, Division of Biology, University of CA, San Diego.
Developed lesson plans and gave lectures in Bacteriology and Medical Microbiology. Topics included structure and function of bacterial carbohydrate structures and disease mechanisms of gram-negative bacterial pathogens. 2005-2007

Instructor, Academic Connections Program, University of CA, San Diego.
Developed and taught “Visualizing the Microworld,” an introductory (3-week) laboratory course in microbiology for promising high school students. Summer, 2004

Teaching Assistant, Division of Biology, University of CA, San Diego.
Assisted in the teaching of Medical Microbiology and Laboratory in Microbiology 2003-2004.

Tutor, Supplemental Instruction Program, Cal State Polytechnic University.
Tutored students enrolled in an undergraduate general biology course for non-majors, 2000–2001.

Graduate Student Committees:

Current Committees at WU: Varsha Raghavan, Drew Schwartz, Elyse Paluscio

Invited Lectures and Presentations (since July 2009):

  1. Invited Lecture: “Streptococcal Sialic Acids and Molecular Mimicry,” Midwest Microbial Pathogenesis Conference St. Louis, MO, Sept. 2010.
  2. Invited Lecture: “ A Question of Perception: How Sialic Acid Structure Influences Molecular Mimicry,” Society for Glycobiology Meeting, St. Pete Beach, FL, Nov. 2010 .
  3. Invited Lecture: “Genomic and Metabolic Profiling of Nonulosonic Acids in Vibrios,” Vibrios in the Environment Conference, Biloxi MS, Nov. 2010.
  4. Invited Seminar: “Glycobiology of Women’s Infectious Diseases” Visiting Lecturer, San Diego Glycobiology Symposium, Feb 2011.
  5. Invited Speaker: “Glycan-Dependent Dynamics of Polymicrobial Urinary Tract Infections” Visiting Lecturer, University of Delaware, Feb. 2011.
  6. Invited Speaker: “Translational Studies of the Female Microbiota in Women's Reproductive Health and Disease: Mucosal Barriers as a Meal for Unwanted Guests” Washington University Women’s and Infants Health Specimen Consortium, Symposium April, 2012

Publications:

  1. Doolittle, R.F. and York, A.L. 2002. Bacterial Actins? An Evolutionary Perspective. BioEssays 24: 293-296.
  2. Lewis, A.L.; Nizet, V.; Varki. A. 2004. Discovery and Characterization of Sialic Acid O-Acetylation in Group B Streptococcus. Proc. Nat. Acad. Sci. U.S.A. 101(30): 11123-11128
  3. Hayakawa, T.; Angata,T.; Lewis, A.L.; Mikkelsen, T.; Varki, N.; Varki, A. 2005 A human-specific gene in microglia. Science 309 (5741):1693.
  4. Lewis, A. L.; Altheide, T.K.; Varki, A.; Arden, K.; Varki, N.M. 2005. Combining Parenting and a Science Career. Science 307(5716): 1720.
  5. Lewis, A.L.; Hensler, M.; Nizet, V; Varki, A. 2006. The group B streptococcal sialic acid O-acetyltransferase is encoded by neuD, a conserved component of bacterial sialic acid biosynthetic gene clusters. J Biol Chem. 281(16):11186.
  6. Carlin, A.F.; Lewis, A.L.; Varki, A.; Nizet, V. 2007. Group B streptococcal capsular sialic acids interact with siglecs (immunoglobulin-like lectins) on human leukocytes.J Bacteriol. 189(4):1231-7.
  7. Lewis, A.L.; Cao, H.; Patel, S.K.; Diaz, S.; Ryan, W.; Carlin, A.F.; Thon, V.; Lewis, W.G.; Varki, A.; Chen, X.; Nizet, V. 2007. NeuA sialic acid O-acetylesterase activity modulates O-acetylation of capsular polysaccharide in Group B Streptococcus. J. Biol. Chem. 282(38):27562-71.
  8. Carlin, A.; Uchiyama, S.; Chang, Y.; Lewis, A.L.; Nizet, V.; Varki, A. 2009. Molecular Mimicry of Host Sialylated Glycans Allows a Bacterial Pathogen to Engage Neutrophil Siglec-9 and Dampen the Innate Immune Response. Blood. 113(14):3333-6.
  9. Pannaraj PS, Edwards MS, Ewing KT, Lewis AL, Rench MA, Baker CJ. 2009. Group B streptococcal conjugate vaccines elicit functional antibodies independent of strain O-acetylation. Vaccine.16;27(33):4452-6.
  10. Lewis, A.L.; Varki, A. Evolutionary Considerations in Studying the Sialome: Sialic Acids and the Host-Pathogen Interface. Bioinformatics for Glycobiology and Glycomics: An Introduction. pgs 69-88. Wiley & Sons Ltd. 2009.
  11. Lewis, A.L.; Desa, N.; Hansen, E.E.; Knirel, Y.; Gordon, J.; Gagneux, P.; Nizet, V.; Varki, A. 2009. Innovations in Host and Microbial Sialic Acid Biosynthesis Revealed by Phylogenomic Prediction of Nonulosonic Acid Structure. Proc. Natl. Acad. Sci. U S A. 11;106(32):13552-7.
  12. Weiman S, Dahesh S, Carlin AF, Varki A, Nizet V, Lewis AL. 2009. Genetic and Biochemical Modulation of Sialic Acid O-Acetylation on Group B Streptococcus: Phenotypic and Functional Impact. Glycobiology. (11):1204-13.
  13. Weiman S, Uchiyama S, Lin FY, Chaffin D, Varki A, Nizet V, Lewis AL. 2010. O-Acetylation of Sialic Acid on Group B Streptococcus Inhibits Neutrophil Suppression and Virulence. Biochem J. 428(2):163-8.
  14. Lewis, A.L.; Lubin, J.B.; Almagro-Moreno, S.; Argade, S.; Naidu, N.; Choudhury, B.; and Boyd, E.F. 2011. Genomic and Metabolic Profiling of Nonulosonic Acids in Vibrionaceae reveal Biochemical Phenotypes of Allelic Divergence in V. vulnificus Appl. Env. Microbiol. Aug;77(16):5782-93. PMID: 21724895
  15. Kline, K.A.; Schwartz, D.J.; Lewis, W.G.; Hultgren, S.J.; Lewis, A.L. 2011. Immune Activation and Suppression by Group B Streptococcus in a Murine Model of Urinary Tract Infection. Infect.Immun. Sep;79(9):3588-95. PMID: 21690238
  16. Lewis, WG; Robinson, LS; Perry, JC; Bick, JL; Peipert, JF; Allsworth, JE; Lewis, AL. 2012. Hydrolysis of Secreted Immunoglobulin A (IgA) in ex Vivo and Biochemical Models of Bacterial Vaginosis. J Biol Chem. 287(3): 2079-89. PMID: 22134918
  17. Lewis AL, Lewis WG. 2012. Host Sialoglycans and Bacterial Sialidases: A Mucosal Perspective. Cell Microbiol. 2012 14(8):1174-82. PMID: 22519819
  18. Ricaldi,JN; Matthias, MA; Vinetz, JM; Lewis, AL. 2012 Expression of Sialic Acids and other Nonulosonic Acids in Leptospira. BMC Microbiol. 12 (1):161. PMID: 22853805
  19. Kline, K.A.; Schwartz, D.J.; Gilbert, NM; Hultgren, S.J.; Lewis, A.L. Immune Modulation by Group B Streptococcus  Influences Host Susceptibility to Urinary Tract Infection by Uropathogenic E. coli  Infect. Immun. 2012 Sept 17. [Epub ahead of print] PMID 22988014