Curriculum Vitae
Amanda L. Lewis
PubMed Publications: for LEWIS + Amanda L
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Academic Appointments:
Education:
Research Experience:
Honors, Awards:
LOCAL
NATIONAL
Teaching/Mentoring Experience
Bio5392, Molecular Microbiology and Microbial Pathogenesis Graduate Course,
Course Instructor, Division of Biology and Biomedical Sciences, Washington University in St Louis Advisor, Intel International Science and Engineering Fair. |
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- Journal of Biological Chemistry
- Glycobiology
- Molecular Microbiology
- American Journal of Obstetrics and Gynecology
- Glycobiology Insights
- Proceedings of the National Academy of Sciences
University Service:
- Global Health and Infectious Diseases Initiative Planning Committee, Fall 2012 - present
- Molecular Microbiology and Microbial Pathogenesis Program Steering Committee Member, Fall 2012-present
- Faculty Search Committee Member - Molecular Microbiology, 2012
- Faculty Search Committee - Molecular Microbiology, Center for Women’s Infectious Disease Research, 2011
- Retreat Organizer – WUSM Microbiology and Microbial Pathogenesis Program - 2010, 2011, 2012
- Graduate Student Representative - UCSD Childcare Oversight Committee, 2004-2006
- Graduate Student Representative - NSF Advance Grant Committee
(for advancing the status of women and families at UCSD), 2005
- Mentor - Upward Bound Program (for first-generation college students), 2002
Professional Affiliations:
(for advancing the status of women and families at UCSD), 2005
Current Committees at WU: Varsha Raghavan, Drew Schwartz, Elyse Paluscio
Invited Lectures and Presentations (since July 2009):
- Invited Lecture: “Streptococcal Sialic Acids and Molecular Mimicry,” Midwest Microbial Pathogenesis Conference St. Louis, MO, Sept. 2010.
- Invited Lecture: “ A Question of Perception: How Sialic Acid Structure Influences Molecular Mimicry,” Society for Glycobiology Meeting, St. Pete Beach, FL, Nov. 2010 .
- Invited Lecture: “Genomic and Metabolic Profiling of Nonulosonic Acids in Vibrios,” Vibrios in the Environment Conference, Biloxi MS, Nov. 2010.
- Invited Seminar: “Glycobiology of Women’s Infectious Diseases” Visiting Lecturer, San Diego Glycobiology Symposium, Feb 2011.
- Invited Speaker: “Glycan-Dependent Dynamics of Polymicrobial Urinary Tract Infections” Visiting Lecturer, University of Delaware, Feb. 2011.
- Invited Speaker: “Translational Studies of the Female Microbiota in Women's Reproductive Health and Disease: Mucosal Barriers as a Meal for Unwanted Guests” Washington University Women’s and Infants Health Specimen Consortium, Symposium April, 2012
Publications:
- Doolittle, R.F. and York, A.L. 2002. Bacterial Actins? An Evolutionary Perspective. BioEssays 24: 293-296.
- Lewis, A.L.; Nizet, V.; Varki. A. 2004. Discovery and Characterization of Sialic Acid O-Acetylation in Group B Streptococcus. Proc. Nat. Acad. Sci. U.S.A. 101(30): 11123-11128
- Hayakawa, T.; Angata,T.; Lewis, A.L.; Mikkelsen, T.; Varki, N.; Varki, A. 2005 A human-specific gene in microglia. Science 309 (5741):1693.
- Lewis, A. L.; Altheide, T.K.; Varki, A.; Arden, K.; Varki, N.M. 2005. Combining Parenting and a Science Career. Science 307(5716): 1720.
- Lewis, A.L.; Hensler, M.; Nizet, V; Varki, A. 2006. The group B streptococcal sialic acid O-acetyltransferase is encoded by neuD, a conserved component of bacterial sialic acid biosynthetic gene clusters. J Biol Chem. 281(16):11186.
- Carlin, A.F.; Lewis, A.L.; Varki, A.; Nizet, V. 2007. Group B streptococcal capsular sialic acids interact with siglecs (immunoglobulin-like lectins) on human leukocytes.J Bacteriol. 189(4):1231-7.
- Lewis, A.L.; Cao, H.; Patel, S.K.; Diaz, S.; Ryan, W.; Carlin, A.F.; Thon, V.; Lewis, W.G.; Varki, A.; Chen, X.; Nizet, V. 2007. NeuA sialic acid O-acetylesterase activity modulates O-acetylation of capsular polysaccharide in Group B Streptococcus. J. Biol. Chem. 282(38):27562-71.
- Carlin, A.; Uchiyama, S.; Chang, Y.; Lewis, A.L.; Nizet, V.; Varki, A. 2009. Molecular Mimicry of Host Sialylated Glycans Allows a Bacterial Pathogen to Engage Neutrophil Siglec-9 and Dampen the Innate Immune Response. Blood. 113(14):3333-6.
- Pannaraj PS, Edwards MS, Ewing KT, Lewis AL, Rench MA, Baker CJ. 2009. Group B streptococcal conjugate vaccines elicit functional antibodies independent of strain O-acetylation. Vaccine.16;27(33):4452-6.
- Lewis, A.L.; Varki, A. Evolutionary Considerations in Studying the Sialome: Sialic Acids and the Host-Pathogen Interface. Bioinformatics for Glycobiology and Glycomics: An Introduction. pgs 69-88. Wiley & Sons Ltd. 2009.
- Lewis, A.L.; Desa, N.; Hansen, E.E.; Knirel, Y.; Gordon, J.; Gagneux, P.; Nizet, V.; Varki, A. 2009. Innovations in Host and Microbial Sialic Acid Biosynthesis Revealed by Phylogenomic Prediction of Nonulosonic Acid Structure. Proc. Natl. Acad. Sci. U S A. 11;106(32):13552-7.
- Weiman S, Dahesh S, Carlin AF, Varki A, Nizet V, Lewis AL. 2009. Genetic and Biochemical Modulation of Sialic Acid O-Acetylation on Group B Streptococcus: Phenotypic and Functional Impact. Glycobiology. (11):1204-13.
- Weiman S, Uchiyama S, Lin FY, Chaffin D, Varki A, Nizet V, Lewis AL. 2010. O-Acetylation of Sialic Acid on Group B Streptococcus Inhibits Neutrophil Suppression and Virulence. Biochem J. 428(2):163-8.
- Lewis, A.L.; Lubin, J.B.; Almagro-Moreno, S.; Argade, S.; Naidu, N.; Choudhury, B.; and Boyd, E.F. 2011. Genomic and Metabolic Profiling of Nonulosonic Acids in Vibrionaceae reveal Biochemical Phenotypes of Allelic Divergence in V. vulnificus Appl. Env. Microbiol. Aug;77(16):5782-93. PMID: 21724895
- Kline, K.A.; Schwartz, D.J.; Lewis, W.G.; Hultgren, S.J.; Lewis, A.L. 2011. Immune Activation and Suppression by Group B Streptococcus in a Murine Model of Urinary Tract Infection. Infect.Immun. Sep;79(9):3588-95. PMID: 21690238
- Lewis, WG; Robinson, LS; Perry, JC; Bick, JL; Peipert, JF; Allsworth, JE; Lewis, AL. 2012. Hydrolysis of Secreted Immunoglobulin A (IgA) in ex Vivo and Biochemical Models of Bacterial Vaginosis. J Biol Chem. 287(3): 2079-89. PMID: 22134918
- Lewis AL, Lewis WG. 2012. Host Sialoglycans and Bacterial Sialidases: A Mucosal Perspective. Cell Microbiol. 2012 14(8):1174-82. PMID: 22519819
- Ricaldi,JN; Matthias, MA; Vinetz, JM; Lewis, AL. 2012 Expression of Sialic Acids and other Nonulosonic Acids in Leptospira. BMC Microbiol. 12 (1):161. PMID: 22853805
- Kline, K.A.; Schwartz, D.J.; Gilbert, NM; Hultgren, S.J.; Lewis, A.L. Immune Modulation by Group B Streptococcus Influences Host Susceptibility to Urinary Tract Infection by Uropathogenic E. coli Infect. Immun. 2012 Sept 17. [Epub ahead of print] PMID 22988014
- Doolittle, R.F. and York, A.L. 2002. Bacterial Actins? An Evolutionary Perspective. BioEssays 24: 293-296.
- Lewis, A.L.; Nizet, V.; Varki. A. 2004. Discovery and Characterization of Sialic Acid O-Acetylation in Group B Streptococcus. Proc. Nat. Acad. Sci. U.S.A. 101(30): 11123-11128
- Hayakawa, T.; Angata,T.; Lewis, A.L.; Mikkelsen, T.; Varki, N.; Varki, A. 2005 A human-specific gene in microglia. Science 309 (5741):1693.
- Lewis, A. L.; Altheide, T.K.; Varki, A.; Arden, K.; Varki, N.M. 2005. Combining Parenting and a Science Career. Science 307(5716): 1720.
- Lewis, A.L.; Hensler, M.; Nizet, V; Varki, A. 2006. The group B streptococcal sialic acid O-acetyltransferase is encoded by neuD, a conserved component of bacterial sialic acid biosynthetic gene clusters. J Biol Chem. 281(16):11186.
- Carlin, A.F.; Lewis, A.L.; Varki, A.; Nizet, V. 2007. Group B streptococcal capsular sialic acids interact with siglecs (immunoglobulin-like lectins) on human leukocytes.J Bacteriol. 189(4):1231-7.
- Lewis, A.L.; Cao, H.; Patel, S.K.; Diaz, S.; Ryan, W.; Carlin, A.F.; Thon, V.; Lewis, W.G.; Varki, A.; Chen, X.; Nizet, V. 2007. NeuA sialic acid O-acetylesterase activity modulates O-acetylation of capsular polysaccharide in Group B Streptococcus. J. Biol. Chem. 282(38):27562-71.
- Carlin, A.; Uchiyama, S.; Chang, Y.; Lewis, A.L.; Nizet, V.; Varki, A. 2009. Molecular Mimicry of Host Sialylated Glycans Allows a Bacterial Pathogen to Engage Neutrophil Siglec-9 and Dampen the Innate Immune Response. Blood. 113(14):3333-6.
- Pannaraj PS, Edwards MS, Ewing KT, Lewis AL, Rench MA, Baker CJ. 2009. Group B streptococcal conjugate vaccines elicit functional antibodies independent of strain O-acetylation. Vaccine.16;27(33):4452-6.
- Lewis, A.L.; Varki, A. Evolutionary Considerations in Studying the Sialome: Sialic Acids and the Host-Pathogen Interface. Bioinformatics for Glycobiology and Glycomics: An Introduction. pgs 69-88. Wiley & Sons Ltd. 2009.
- Lewis, A.L.; Desa, N.; Hansen, E.E.; Knirel, Y.; Gordon, J.; Gagneux, P.; Nizet, V.; Varki, A. 2009. Innovations in Host and Microbial Sialic Acid Biosynthesis Revealed by Phylogenomic Prediction of Nonulosonic Acid Structure. Proc. Natl. Acad. Sci. U S A. 11;106(32):13552-7.
- Weiman S, Dahesh S, Carlin AF, Varki A, Nizet V, Lewis AL. 2009. Genetic and Biochemical Modulation of Sialic Acid O-Acetylation on Group B Streptococcus: Phenotypic and Functional Impact. Glycobiology. (11):1204-13.
- Weiman S, Uchiyama S, Lin FY, Chaffin D, Varki A, Nizet V, Lewis AL. 2010. O-Acetylation of Sialic Acid on Group B Streptococcus Inhibits Neutrophil Suppression and Virulence. Biochem J. 428(2):163-8.
- Lewis, A.L.; Lubin, J.B.; Almagro-Moreno, S.; Argade, S.; Naidu, N.; Choudhury, B.; and Boyd, E.F. 2011. Genomic and Metabolic Profiling of Nonulosonic Acids in Vibrionaceae reveal Biochemical Phenotypes of Allelic Divergence in V. vulnificus Appl. Env. Microbiol. Aug;77(16):5782-93. PMID: 21724895
- Kline, K.A.; Schwartz, D.J.; Lewis, W.G.; Hultgren, S.J.; Lewis, A.L. 2011. Immune Activation and Suppression by Group B Streptococcus in a Murine Model of Urinary Tract Infection. Infect.Immun. Sep;79(9):3588-95. PMID: 21690238
- Lewis, WG; Robinson, LS; Perry, JC; Bick, JL; Peipert, JF; Allsworth, JE; Lewis, AL. 2012. Hydrolysis of Secreted Immunoglobulin A (IgA) in ex Vivo and Biochemical Models of Bacterial Vaginosis. J Biol Chem. 287(3): 2079-89. PMID: 22134918
- Lewis AL, Lewis WG. 2012. Host Sialoglycans and Bacterial Sialidases: A Mucosal Perspective. Cell Microbiol. 2012 14(8):1174-82. PMID: 22519819
- Ricaldi,JN; Matthias, MA; Vinetz, JM; Lewis, AL. 2012 Expression of Sialic Acids and other Nonulosonic Acids in Leptospira. BMC Microbiol. 12 (1):161. PMID: 22853805
- Kline, K.A.; Schwartz, D.J.; Gilbert, NM; Hultgren, S.J.; Lewis, A.L. Immune Modulation by Group B Streptococcus Influences Host Susceptibility to Urinary Tract Infection by Uropathogenic E. coli Infect. Immun. 2012 Sept 17. [Epub ahead of print] PMID 22988014