Curriculum Vitae
Jennifer K. Lodge



PubMed Publications: for lodge + JK
Division of Biology and Biomedical Sciences profile

Office Address: Department of Molecular Microbiology
Washington University School of Medicine
8250 McDonnell Pediatric Research Building
Campus Box 8230
660 S. Euclid Ave.
St. Louis, MO 63110
Phone, office: 314-286-2125
Email: lodgejk [at] wustl.edu
   

 

 

Education:

1979 B.A. with Honors, Oberlin College, Oberlin, OH
1988 Ph.D., Washington University, St. Louis, MO

Honors and Awards:

1982-1985 G-POP Predoctoral Fellowship
1998-2001 Burroughs Wellcome New Investigator in Molecular Pathogenic Mycology
2010 Fellow, American Academy of Microbiology
2011 Fellow, AAAS

Academic Positions:

2009 - present Professor, Department of Molecular Microbiology,
Washington University School of Medicine, St. Louis MO
2009 - present Associate Dean for Research
Washington University School of Medicine, St. Louis MO
2009-2011 Adjunct Professor, Department of Biochemistry and Molecular Biology,
Saint Louis University School of Medicine, St. Louis MO
2007-2009 Professor, Department of Biochemistry and Molecular Biology
Saint Louis University School of Medicine, St. Louis MO
2005-2007 Associate Dean for Research
Saint Louis University School of Medicine, St. Louis MO
2003-2007 Associate Professor, Department of Biochemistry and Molecular Biology,
Saint Louis University School of Medicine, St. Louis MO
2002-2009 Secondary Appointment, Department of Molecular Microbiology and Immunology
Saint Louis University School of Medicine, St. Louis MO
1998-2003 Assistant Professor, Department of Biochemistry and Molecular Biology,
Saint Louis University School of Medicine, St. Louis MO
1995-1997 Research Assistant Professor, Dept. of Molecular Biology and Pharmacology
Washington University School of Medicine, St. Louis MO
1993-1995 Research Instructor, Department of Molecular Biology and Pharmacology,
Washington University School of Medicine, St. Louis MO

Patents:

Kaniewski, W., J. K. Lodge and N. E. Tumer. Virus resistant potato plants (1992) Patent 6,015,940 38-21(10547)A

Selected Publications:

  1. Donlin M.J., Upadhya R., Gerik, K., Lam, W., Van Arendonk L.G., Specht, C.A., Sharma, N.K.*, and Lodge, J.K. (2014) Cross talk between the cell wall integrity and cAMP/protein kinase A pathways in Cryptococcus neoformans. mBio In Press.

    Upadhya, R., Donlin, M.J., and Lodge, J.K. (2014) Cryptococcus at work: gene expression during human infection. mBio Commentary. 5(2). PMID: 24757217

    Janbon G, Ormerod KL, Paulet D, Byrnes EJ, Chatterjee G, Yadav V, Hon CC, Billmyre RB, Brunel F, Bahn Y-S, Chen W, Chen Y, Chow EWL, Coppée J-Y, Floyd-Averette A, Gaillardin C, Gerik KJ, Goebels C, Goldberg J, Gonzalez-Hilarion S, Gujja S, Hamlin JL, Hsueh Y-P, Ianiri; Jones GS, Kodira CD, Lam W, Marra M, Mesner LD, Mieczkowski PA, Moyrand F, Nielsen K, Proux C, Rossignol T, Schein JE, Sun S, Wood IA, Zeng Q, Neuvéglise C, Newlon CS, Perfect JR, Lodge JK, Idnurm A, Stajich JE, Kronstad JW, Sanyal K, Heitman J, Fraser JA, Cuomo CA, Dietrich FS (2014) The genome and transcriptome sequences of Cryptococcus neoformans var. grubii reveal complex mechanisms of RNA expression and virulence plasticity. PLoS Genetics 10(4):e1004261. PMID: 24743168

    Upadhya R, Kim H, Jung K-W, Park G , Lam W, Lodge JK, and Bahn Y-S (2013) Sulfiredoxin plays peroxiredoxin-dependent and –independent roles via the HOG signaling pathway in Cryptococcus neoformans and contributes to fungal virulence. Mol. Micro. 90:630-48. PMID: 23998805

    Upadhya R., Campbell, L.T., Donlin, M.J., Aurora, R., Lodge, J.K. (2013) Global transcriptome profile of Cryptococcus neoformans during exposure to hydrogen peroxide induced oxidative stress. PLoS One. 8 (1):e55110. PMID: 23383070. PMCID: PMC3557267

    Lam, W.C., Gerik, K.J., and Lodge, J.K. (2013) Role of Cryptococcus neoformans Rho 1 GTPases in the PKC1 signaling pathway in response to thermal stress. Eukaryot Cell. 12(1): 118-31. PMID:23159519.

    Chabrier-Rosello, Y., Gerik, K.J., Koselny, K., DiDone, L., Lodge, J.K., and Krysan, D.J. (2013) Cryptococcus neoformans phosphoinositide-dependent kinase 1 (PDK 1) ortholog is required for stress tolerance and survival in murine phagocytes. Eukaryot Cell. 12:12-22. PMID: 23087368.

    Lam, WC, Gerik, KJ, and Lodge, JK (2012) Role of Cryptococcus neoformans Rho1 GTPases in the PKC1 signaling pathway in response to thermal stress. Eukaryotic Cell. Accepted with minor revision.

  2. Gilbert NM, Baker LG, Specht, CA and Lodge JK. (2012) A glycosylphosphatidylinositol anchor is required for membrane localization but dispensable for cell wall association of chitin deacetylase 2 in Cryptococcus neoformans. mBio In press.

  3. Baker LG, Specht CA and Lodge JK. (2011) Cell wall chitosan is necessary for virulence in the opportunistic pathogen Cryptococcus neoformans. Eukaryot Cell. 10:1264-8.

  4. Brown, S.M., Upadhya, R. Shoemaker, J.D., and Lodge, J.K. (2010) Isocitrate Dehydrogenase is Important for Nitrosative Stress Resistance in Cryptococcus nerformans, but Oxidative Stress Resistance in Not Dependant on Glucose-6-Phosphate Dehydrogenase. Eukaryotic Cell. 2010 Jun;9(6):971-80. PMID 20400467.

  5. Gilbert NM, Donlin MJ, Gerik KJ, Specht CA, Djordjevic JT, Wilson CF, Sorrell TC, Lodge JK. (2010) KRE genes are required for beta-1,6-glucan synthesis, maintenance of capsule architecture and cell wall protein anchoring in Cryptococcus neoformans. Mol. Microb. 76(2):517-34. PMID 20384682.

  6. Baker LG, Specht CA, and Lodge JK. (2009) Chitinases are essential for sexual development but not vegetative growth in Cryptococcus neoformans. Eukaryotic Cell. 8:1692-705. Epub 2009 Sep. 4. PMID 19734369.

  7. Gerik, K.J, Bhimireddy, S. R., Ryerse J. S., Specht, C. A. and Lodge, J.K. (2008) Protein Kinase C1 (PKC1) is essential for protection against both oxidative and nitrosative stress, cell integrity, and normal manifestation of virulence factors in the pathogenic fungus Cryptococcus neoformans. Eukaryotic Cell, 7:1685-98. PMID 18689526.

  8. Brown, S.M., Campbell, L. T. and Lodge, J.K. (2007) Cryptococcus neoformans: A Fungus Under Stress. Current Opinions in Microbiology. 10:320-5. PMID 177076585.

  9. Baker L.G., Specht, C. A. Donlin, M. J. and Lodge, J. K. (2007) Chitosan, the deacetylated form of chitin, is necessary for cell wall integrity in Cryptococcus neoformans. Eukaryotic Cell. 6:855-867. PMID 17400891.

  10. Missall T.A, Pusateri M.E., Donlin M.J., Chambers K.T., Corbett J.A., and Lodge J.K. (2006) Post-translational, translational, and transcriptional responses to nitric oxide stress in Cryptococcus neoformans: implications for virulence. Eukaryotic Cell. 5:518-529. PMID 16524907.

  11. Banks, I. R., Specht, C. A., Donlin M.J., Gerik K. J., and Lodge J.,K. (2005) Chitin and Chitosan are critical for growth in the fungal pathogen Cryptococcus neoformans. Eukaryotic Cell, 4:1902-12. PMID 16278457

  12. Missall, T.A. and Lodge, J.K. (2005) Function of the thioredoxin proteins in Cryptococcus neoformans during stress or virulence and regulation by putative transcriptional modulators. Molecular Microbiology, 57:847-858. PMID 16045626

  13. Missall, T.A., Cherry-Harris, J.F. and Lodge, J.K. (2005) Two glutathione peroxidases in the fungal pathogen, Cryptococcus neoformans, are expressed in the presence of specific substrates. Microbiology 151: 2573-2581. PMID 16079336

  14. Gerik, K.J., Donlin, M.J., Soto C.E., Banks, A.M., Banks I.R., Maligie, M.A., Selitrennikoff, C.P. and Lodge, J.K. (2005) Cell wall integrity is dependent on the PKC1 signal transduction pathway in Cryptococcus neoformans. 58: 393-408. PMID 16194228.

  15. Loftus,B, Eula Fung E, Roncaglia P, Rowley D, Amedeo P, Bruno D, Vamathevan J, Miranda M, Anderson I, Fraser JA, Allen J, Bosdet I, Brent MR, Chiu R, Doering TL, Donlin MJ, D’Souza CL, Fox DS, Grinberg V, Fu J, Fukushima M, Haas B, Huang JC, Janbon G, Jones,S, Krzywinski MI, Kwon-Chung J, Lengeler KB, Maiti R, Marra M, Marra RE, Mathewson C, Mitchell TG, Pertea M, Riggs F, Salzberg SL, Schein J, Shvartsbeyn A, Shin,H, Specht C, Suh B, Tenney A, Utterback T, Wickes BL, Wye N, Kronstad JW, Lodge JK, Heitman J, Davis RW, Fraser CM, and Hyman RW. (2005) The genome and transcriptome of Cryptococcus neoformans, a basidiomycetous fungal pathogen of humans Science 307:1321-1324. PMID 15653466

  16. Missall, T. A., Moran, J. M., Corbett, J. A., and Lodge, J. K. (2005) Distinct stress responses of two functional laccases in Cryptococcus neoformans is revealed in the absence of the thiol-specific antioxidant, Tsa1. Eukaryotic Cell. 4:202-8. PMID 15643075

  17. Missall T. A. and Lodge, J.K. (2005) Thioredoxin reductase is essential for viability in the fungal pathogen, Cryptococcus neoformans Eukaryotic Cell 4:487-9. PMID 15701811

  18. Missall, T. A, Pusateri, M. E. and Lodge, J. K. (2004) Thiol peroxidase is critical for virulence and resistance to nitric oxide and peroxide in the fungal pathogen, Cryptococcus neoformans. Mol. Microbiology 51:1447-1458. PMID 14982637.

  19. Nelson, R.T., Pryor, B., and Lodge, J.K. (2003) Sequence length required for homologous recombination in Cryptococcus neoformans. Fungal Genetics and Biology 38:1-9. PMID 12553931.

  20. Nelson, R.T., Hua, J., Pryor, B., and Lodge, J.K. (2001) Identification of virulence mutants of the fungal pathogen, Cryptococcus neoformans using signature tagged mutagenesis. Genetics 157:935-947. PMID 11238384.