Washington University School of Medicine
Department of Molecular Microbiology
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CURRICULUM VITAE
Milton j. schlesinger

PubMed Publications: for schlesinger + MJ

Office Address: Departments of Molecular Microbiology
Washington University School of Medicine
   

 

 

Education:

1951 B.S. Physics, Yale University, New Haven, CT
1953 M.S. Biophysics, University of Rochester, Rochester, NY
1959 Ph.D. Biochemistry, University of Michigan, Ann Arbor, MI

Academic Positons:

Present:  Professor Emeritus, Washington University School of Medicine, Department  of Molecular Microbiology, St. Louis, MO
1953-1956            Research Associate, University of Michigan, Ann Arbor, MI         
1959-1960            Research Associate, University of Michigan, N.I.H. Postdoctoral Fellow, Ann Arbor, MI
1960-1961            Guest Research Investigator, N.S.F. Postdoctoral Fellow, Istituto Superiore di Sanita, Rome, Italy
1961-1964            Research Associate, Massachusetts Inst. of Technology, Dept. of Biology Cambridge, MA.
1964-1967            Assistant Professor, Washington University School of Medicine, Dept. of Microbiology, St. Louis, MO
1967-1972            Associate Professor, Washington University School of Medicine, Dept. of Microbiology, St. Louis, MO
1972-2000            Professor, Washington University School of Medicine, Department of Molecular Microbiology, St. Louis, MO
1967-1973            Acting Chairman, Dept. of Microbiology, Washington University School of Medicine, St. Louis, MO
1973-1975
1987-1989
1974-1975            Visiting Scientist; Imperial Cancer Research Fund Laboratories, Depts. of RNA Tumor Virus Genetics and Viral                                  Oncology, London, England
1977-1985            Associate Director, Center for Basic Cancer Research, Washington University School of Medicine, St. Louis, MO
1989-1990            Visiting Scholar, Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, MA.
1992-1994            Chairman, Executive Council, Division of Biology and Biomedical Sciences Washington University St. Louis, MO
1995-1996            Visiting Scholar, Department of  Molecular and Cellular Biology, Harvard University, Cambridge, MA

Research Program:

Molecular biology of Sindbis virus replication - emphasis on virus assembly and budding.

Publications (Since 1990 only):

96. Gaedig-Nitschko, K. and Schlesinger ,M.J. (1990) The Sindbis virus 6K protein can be detected in virions and is acylated with fatty acid. Virology 175, 274-281

97. Gaedig-Nitschko, K., Ding, M., Levy, M.A. and Schlesinger, M.J. (1990) Site-directed mutations in the Sindbis Virus 6K protein reveal sites for fatty acylation and the underacylated protein affects virus release and virion structure. Virology 125, 282-291

98. Nowak, T.S. Jr., Bond. U. and Schlesinger, M.J. (1990). Heat shock RNA levels in brain and other tissues after hyperthermia and transient ischemia. J. Neurochemistry 54: 451-458

99. Agell, N., Ryan, C., and Schlesinger, M.J. (1991) Purification and substrate specificity of a ubiquitin hydrolase from Saccharomyces cerevisiae Biochem. J. 273: 615-620.

100. Gaedigk-Nitschko, K. and Schlesinger, M.J. (1991) Site-directed mutations in Sindbis virus E2 glycoprotein's cytoplasmic domain and the 6K prtotein lead to similar defects in virus assembly and budding. Virology 183: 206-214.

101. Collier, N.C., Knox, K. and Schlesinger, M.J. (1991) Inhibition of influenza virus formation by a peptide that corresponds to sequence in the cytoplasmic domain of the hemagglutinin. Virology 183: 769-722.

102. Collier, N.C., Adams, S.P., Weingarten, H. and Schlesinger, M.J. (1992) Inhibition of enveloped RNA virus formation by peptides corresponding to glycoprotein sequences. Antiviral Chemistry and Chemotherapy 3: 31-36.

103. Ryan, C., Steven, T.H. and Schlesinger, M.J. (1992) Inhibitory effects of HSP70 chaperones on nascent polypeptides. Protein Science 1: 980-985.

104. Harrison, S.H, Strong, R.K., Schlesinger, S. and Schlesinger, M.J. (1992) Crystallization of Sindbis virus and its nucleocapsid. J. Mol. Biol 226: 277-280.

105. Schlesinger, M.J., London,S.D. and Ryan, C. (1992) An inframe insertion into the Sindbis virus 6k gene leads to defective proteolytic processing of the virus glycoproteins, a trans dominant negative inhibition of normal virus formation and interference in virus shutoff of host-cell protein synthesis. Virology 193: 424-432.

106. Ivanova, L. and Schlesinger, M.J. (1993) Site-directed mutations in the Sindbis virus E2 glycoprotein identify palmitoylation sites and affect virus budding. J. Virology 67: 2546-2551.

107. Collier, N.C., Sheetz, M. P. and Schlesinger M.J. (1993) Concomitant changes in mitochondria and intermediate filaments during heat shock and recovery of chicken embryo fibroblasts. J. Cell. Biochemistry 53: 1-11.

108. Schlesinger, M.J. and Ryan, C. (1993) An ATP- and hsc70-dependent oligomerization of nascent heat-shock factor (HSF) polypeptide suggests that HSF itself could be a "sensor" for the cellular stress response. Protein Science 2: 1356-1360.

109. Loewy, A, Smyth, J., von Bonsdorff, C-H., Liljestrom, P. and Schlesinger, M.J. (1995) The 6-kilodalton membrane protein of Semliki Forest virus is involved in the budding process. J. Virol. 69:469-475

110. Ivanova, L., Lustig, S. and Schlesinger, M.J. (1995) A pseudo-revertant of a Sindbis virus 6Kprotein mutant, which corrects for aberrant particle formation, contains two new mutations that map to the ectodomain fo the E2 glycoprotein. Virology 206: 1027-1034.

111. Ivanova, L., Lam, L., and Schlesinger, M.J. (1995) Characterization of revertants of a Sindbis virus 6K mutant that affects proteolytic processing and virus assembly. Virus Research 39: 165-179.

112. Ryan, C., Mo, J. and Schlesinger, M.J. (1995) Antiviral Activities of Peptides with Sequences Related to the Cytoplasmic Domain of the Respiratory Syncytial Virus glycoprotein. Antiviral Chemistry and Chemotherapy 6: 391-397.

113. Schlesinger, M.J., Ryan, C., M.-Y.Chi, M., Carter, J.G., Pusateri, M.E. and Lowry, O. (1997) Metabolite changes associated with heat shocked avian fibroblast mitochondria. Cell Stress & Chaperones 2: 25-30.

114. Lowey, A., Gorka, J., Mo, J., Ryan, C. and Schlesinger, M.J. (1997). Pleiotropic effects of small peptides corresponding in sequence to the cytoplasmic domain of the influenza hemagglutinin on formation and infectivity of influenza, vesicular stomatitis and Sindbis viruses. Antiviral Chemistry and Chemotherapy 8 (4): 311-315.

115. Ryan, C., Ivanova, L. and Schlesinger, M.J. (1998). Mutations in the Sindbis virus capsid gene can partially suppress mutations in the cytoplasmic domain of the virus E2 glycoprotein spike. Virology 243: 380-387.

116. Ryan, C., Ivanova, L. and Schlesinger, M.J. (1998). Effects of site-directed mutations of transmembrane cysteines in Sindbis virus E1 and E2 glycoproteins on palmitylation and virus replication. Virology 249: 62-67.

REVIEW ARTICLES

18. Schlesinger, S. and Schlesinger, M.J. (1990) Replication of Togaviruses and Flaviviruses. Fields, B.N. et al, (eds) In: Fields Virology, 2nd Ed. Raven Press, N.Y. pp.697-712

19 Schlesinger, S. and Schlesinger, M.J. (1990) Replication of Togaviruses and Flaviviruses . Fields, B.N. et al, (eds) In: Fundamental Virology, 2nd Ed. Raven Press, N.Y. pp.453-470.

20. Schlesinger, M.J., and Collier, N.C. (1991) Heat shock In: Encyclopedia of Human Biology Vol. 4: 99-106. Academic Press.

21. Schlesinger, M.J. (1990) Heat Shock Proteins (a minireview) J. Biol. Chem 265: 12111-12114.

22. Schlesinger, M.J., Veit, M. and Schmidt, M.F.G. (1992) Palmitoylation of cellular and viral proteins. In: "Lipid Modifications of Proteins", Schlesinger, M.J. (ed) CRC Press Boca Raton pp:1-20.

23 Schlesinger, M.J., editor (1992) Lipid Modifications of Proteins CRC Press, Boca Raton

24. Schlesinger, M.J. (1994) Sindbis and Semliki Forest Viruses In::"Encyclopedia of Virology", Webster, R.G. and Granoff, A. (eds), Academic Press Ltd. pp 1330-1333.

25. Schlesinger, M.J. (1994) Alphaviruses In: " Handbook of Neurovirology", McKendall, R.R. and Stroop, W.G. (eds), Marcell Dekker, N.Y. pp 369-378

26. Schlesinger, M. J. (1994) How the cell copes with stress and the function of heat shock proteins. Pediatric Research 36; 1-6.

27. Schlesinger, S. and Schlesinger, M.J. (1995) Togaviridae: The Viruses and their Replication. Fields, B.N. et al, (eds) In: Fields Virology, 3rd ed. Lippincott-Raven: pp 825-842.

28. Schlesinger, S. and Schlesinger, M.J. (1995) Togaviridae: The Viruses and their Replication. Fields, B.N. et al, (eds) In: Fundamental Virology, 3rd ed. Lippincott: pp 523-540.

29. Schlesinger, M.J. (1995) Viral Envelope Assembly and Budding, in " Molecular Biology and Biotechnology" VCH pub. N.Y. pp948-950

30. Schlesinger, M.J. (1996) Reflections: Heat shock in vertebrate cells. Cell Stress & Chaperones 1, 213-214.

31. Schlesinger, M.J. (1997) Heat stress in avian cells, in "Stress Inducible Processes in Higher Eukaryotic Cells" T.M. Koval (ed.) Plenum Press, N.Y. pp 165-185.

32. Schlesinger, M.J. (1997) Viral Envelope Assembly and Budding. In "Encyclopedia of Molecular Biology and Molecular Medicine" Vol 6. VCH Publishers Inc., N.Y. pp 183-191

33. Schlesinger, M.J. (1997) Heat shock In: Encyclopedia of Human Biology, 2nd Ed. Vol 4, pp 467-476. Academic Press, San Diego.

34. Schlesinger, M.J. (1997) Sindbis and Semliki Forest Viruses In::"Encyclopedia of Virology", 2nd Edition. Webster, R.G. and Granoff, A. (eds), Academic Press Ltd. in press

35. Schlesinger, S. and Schlesinger, M.J. (1999) Viruses In::"Encyclopedia of Microbiology", 2nd Edition. Lederberg, J. et al (eds), Academic Press Ltd. Submitted.

 

 

 
 

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