Washington University School of Medicine
Department of Molecular Microbiology
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CURRICULUM VITAE
L. David Sibley

PubMed Publications: for sibley + LD
Division of Biology and Biomedical Sciences profile

Office Address: Department of Molecular Microbiology
Washington University School of Medicine
660 S. Euclid Ave.
St. Louis, MO 63110
Phone, office: (314)-362-8873
Phone, lab: (314)-362-8874
FAX: (314)-362-3203
Email: sibley [at] wusm.wustl.edu
   

 

 

Education:

1978 B.A., Oberlin College, Oberlin Ohio
1985 Ph.D., Louisiana State University, Baton Rouge. LA

Academic Positions:

2002-present Professor,
Department of Molecular Microbiology,Washington University School of Medicine, St. Louis, MO
1998-2002 Associate Professor
Department of Molecular Microbiology,Washington University School of Medicine, St. Louis, MO
1991-1998 Assistant Professor
Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO
1987-1991 Postdoctoral Research Fellow
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA
1985-1987 Research Scientist
Laboratory Research Department, U.S.P.H.S., National Hansen's Disease Center, Carville, LA


Honors and Awards:

1993-1997 New Investigator Award in Molecular Parasitology Burroughs Wellcome Fund
1999-2000 Excellence in Mentoring Award, Graduate Student Senate, Washington University
2000-2005 Scholar Award in Molecular Parasitology Burroughs Wellcome Fund
2004-2005 Excellence in Mentoring Award, Graduate Student Senate, Washington University
2007 American Academy of Microbiology, Elected Fellow

Selected Publications:

  1. Alaganan A, Fentress SJ, Tang K, Wang Q, Sibley LD: Toxoplasma GRA7 effector increases turnover of immunity-related GTPases and contributes to acute virulence in the mouse. Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1126-31. PMID: 24390541

  2. Skillman KM, Ma C, Fremont DH, Cooper JA, Sept D, Sibley LD: The unusual dynamics of Toxoplasma actin result from isodesmic polymerization.  Nat. Comm. 2013, 4:2285. PMID: 23921463.

  3. Sibley LD: The roles of intramembrane proteases in protozoan parasites.  BBA Biomembranes 2013, 1828; 2908-2915. PMID: 24099008.

  4. Selleck EM, Fentress SJ, Beatty WL, Degrandi D, Pfeffer K, Virgin HW, MackMicking JD, and Sibley LD: Guanylate-binding protein 1 (Gbp1) contributes to cell-autonomous immunity against Toxoplasma gondii PloS. P., 2013 e1003320. PMID: 23633952.

  5. Lourido S, Zhang C, Lopez M, Tang K, Barks J, Wang Q, Wildman SA, Shokat KM, and LD Sibley.  Optimizing small molecule inhibitors of calcium-dependent protein kinase 1 to prevent infection by Toxoplasma gondii. J. Med. Chem. 2013 56:3068-77. PMID: 23470217.

  6. Lourido S, Jeschke GR, Turk BE, and LD Sibley: Exploiting the unique ATP-binding pocket of Toxoplasma calcium-dependent protein kinase 1 to identify its substrates. ACS Chem. Biol. 2013,8:1155-1162.  PMID: 23530747

  7. Shen B, and Sibley LD: The moving junction, a key portal to host cell invasion by apicomplexan parasites.  Curr. Opin. Micro. 2012, 15, 449-455. PMID: 22445360.

  8. Hunter C, Sibley LD: Modulation of innate immunity by Toxoplasma gondii virulence effectors. Nat, Rev Microb. 2012, 10(11):766-78. PMID: 23070557.

  9. Behnke MS, Fentress SJ, Mashayekhi M, Virgin HW, Sibley LD: The polymorphic pseudokinase ROP5 controls virulence in Toxoplasma gondii by regulating the active kinase ROP18.  Plos P., 2012, 8(11): e1002992. PMID: 23144612.

  10. Lourido S, Tang K, Sibley LD: Distinct signaling pathways control Toxoplasma egress and host-cell invasion. EMBOJ, 2012 31, 4514-4534. PMID: 23149386.

  11. Su CL, Khan A, Zhou P, Majumdar D, Ajzenberg D, Dardé ML, Zhu XQ, Ajioka JW, Rosenthal B, Dubey JP Sibley LD: Globally diverse Toxoplasma gondii isolates comprise six major clades originating from a small number of distinct ancestral lineages. Proc. Natl. Acad. Sci. (USA), 2012, 109:5844-9. PMID: 22431627.

  12. Sibley LD: Invasion and intracellular survival by protozoan parasites. Immunol. Rev. 2011, 240, 72-91. PMID: 21349087.

  13. Khan A, Miller N, Roos DS, Dubey JP, Ajzenberg D, Darde ML, Ajioka JW, Rosenthal B, Sibley LD: A monomorphic haplotype of chromosome Ia is associated with widespread success of clonal and nonclonal populations of Toxoplasma gondii. mBio, 2011, 2:e00228-11. PMID: 22068979.

  14. Skillman KM, Diraviyam K, Khan A, Tang K, Sept D, Sibley LD: Evolutionarily divergent, unstable filamentous actin is essential for gliding motility in apicomplexan parasites.  PLoS Pathogens, 2011, 7(10): e1002280. PMID: 21998582.

  15. Mashayekhi M, Sandau MM, Dunay IR, Fickel EM, Khan A, Goldszmid RS, Sher A, Ploegh HL, Murphy TL, Sibley LD, Murphy KM: CD8 alpha dendritic cells are the critical source of IL-12 controlling acute infection by Toxoplasma gondii tachyzoites.  Immunity, 2011, 35, 249-259. PMID: 21867928.

  16. Mehta S, Sibley LD: Actin Depolymerizing Factor controls actin turnover and gliding motility in Toxoplasma gondiiMolec. Biol. Cell, 2011, 22, 1290-1299. PMID: 21346192.

  17. Behnke MS, Khan A, Wootton JC, Dubey JP, Tang K, Sibley LD: Virulence differences in Toxoplasma mediated by amplification of a family of polymorphic pseudokinases. Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9631-6. PMID: 21586633

  18. Fentress SJ, Behnke MS, Dunay IR, Mashayekhi M, Rommereim LM, Fox BA, Bzik DJ, Taylor GA, Turk BE, Lichti CF, Townsend RR, Qiu W, Hui R, Beatty WL, Sibley LD: Phosphorylation of immunity-related GTPases by a parasite secretory kinase promotes macrophage survival and virulence. Cell Host Microbe, 2010, 16;8(6):484-95. PMID: 21147463.

  19. Steinfeldt T, Konen-Waisman S, Tong L, Pawlowski N, Lamkemeyer T, Sibley LD, Hunn JP, Howard JC: Phosphorylation of IRG resistance proteins is an evasion strategy for virulent ToxoplasmaPLoS Biol, 2010, 8(12):e1000576. PMID: 21203588.

  20. Dunay I, Sibley LD: Monocytes mediate mucosal immunity to Toxoplasma gondii.  Curr. Opin. Immunol. 2010, 22, 461-466. PMID: 20537517.

  21. Lourido S, Shuman J, Zhang C, Shokat KM, Hui R, and Sibley LD: Calcium dependent kinase 1 is an essential regulator of microneme secretion in Toxoplasma gondiiNature, 2010, 465, 359-362. PMID: 20485436.

  22. Bugaliskis J, Brossier F, and Sibley LD:  Shedding of surface adhesins by rhomboid 4 is required for efficient invasion of Toxoplasma gondiiPLoS Path., 2010,6(4), e1000858. PMID: 20421941.

  23. Metha S, and Sibley LD:  Toxoplasma gondii  actin deploymerizing factor acts primarily to sequester G actin.  J. Biol. Chem., 2010, 285, 6835-6847. PMID: 20042603.

  24. Wernimont AK, Artz, JD,  Finerty P, Lin Y, Amani M, Allali-Hassani A, Vedadi M, Tempel W, Mackenzie F, Lourido S, Sibley LD, Hui R: Structural analysis of calcium-dependent protein kinases reveals a new twist in calcium sensing.  Nature Struct. Molec. Biol., 2010, 17, 596-601. PMID: 20436473.

  25. Qiu W, Wernimont A, Taylor S, Tang K, Schapira M, Fentress S, Hui R, and Sibley LD: Structural and functional insights into a novel family of secretory serine-threonine kinases in Toxoplasma gondii. EMBO J., 2009, 28, 969-979. PMID: 19197235.

  26. Starnes GL, Coincon M, Sygusch J, and Sibley LD: Aldolase is essential for energy production and bridging adhesin-cytoskeletal interactions during parasite invasion of host cells.  Cell Host Microbe, 2009, 5, 353-364. PMID:

  27. Billker O, Lourido S, and Sibley LD: Calcium-dependent signaling and kinases in apicomplexan parasites.  Cell Host Microbe, 2009, 5, 612-622. PMID: 19527888.

  28. Khan A, Taylor S, Ajioka JW, Rosenthal BM, and Sibley LD: Selection at a single locus leads to widespread expansion of virulence in Toxoplasma gondii.  PLoS Genetics, 2009, 5, e1000404. PMID: 19266027.

  29. Dunay IR, Damatta RA, Fux B, Presti R, Greco SE, Collona M, and Sibley LD: Gr1+ (Ly6C+) inflammatory monocytes are required for mucosal resistance to the pathogen Toxoplasma gondiiImmunity, 2008, 29, 306-317. PMID: 18691912.

  30. Zhao Z, Fux B, Strong D, Miller BC, Cadwell K, Delgado M, Pnopuak M, Gren KG, Schidt RE, Mizushima N, Deretic V, Sibley LD, and Virgin HW: The autophagy gene ATG5 is essential for cellular immunity to intracellular pathogens.  Cell Host Microbe, 2008, 4, 458-469. PMID: 18996346.

  31. Nagamune K, Hicks LM, Fux B, Brossier F, Chini EN, and Sibley LD: Abscisic acid controls calcium-dependent egress and development in Toxoplasma gondiiNature, 2008, 451, 207-210. PMID: 18185591.

  32. Sibley LD, Ajioka JW: Population structure of Toxoplasma gondii: clonal expansion driven by infrequent recombination and selective sweeps. Annu Rev Microbiol. 2008;62:329-51. PMID: 18544039

  33. Khan A, Fux BF, Su C, Dubey JP, Darde ML, Ajioka JW, Rosenthal BM, Sibley LD: Recent transcontinental sweep of Toxoplasma gondii driven by a single, monomorphic chromosome. Proc, Nat. Acad. Sci. (USA), 2007,104, 14872-14877. PMID: 17804804.

  34. Saeij JPJ, Boyle JP, Coller SC, Taylor S, Sibley LD, Brooke-Powell ET, Ajioka JW, and Boothroyd JC: Polymorphic secreted kinases are key virulence factors in toxoplasmosis.  Science, 2006, 314, 1780-1783. PMID: 17170306.

  35. Taylor A, Barragan A, Su C, Fux B, Fentress SF, Tang K, Beatty WL, El Hajj H, Jerome M, Behnke MS, White M, Wootton JC, and Sibley LD: A secreted serine-threonine kinase determines virulence in the eukaryotic pathogen Toxoplasma gondii  Science, 2006, 314, 1776-1780. PMID: 17170305.

  36. Sibley LD, Ajioka JW: Population structure of Toxoplasma gondii: clonal expansion driven by infrequent recombination and selective sweeps. Annu Rev Microbiol. 2008;62:329-51.

  37. Nagamune K, Hicks LM, Fux B, Brossier F, Chini EN and Sibley LD: Abscisic acid controls calcium-dependent egress and development in Toxoplasma gondii. Nature, 2008, 451:207-210.

  38. Dunay IR, Damatta RA, Fux B, Presti R, Greco SE, Collona M, and Sibley LD: Gr1+ (Ly6C+) inflammatory monocytes are required for mucosal resistance to the pathogen Toxoplasma gondii. Immunity, 2008, 29: 306-317.

  39. Khan A, Fux BF, Su C, Dubey JP, Darde ML, Ajioka JW, Rosenthal BM, Sibley LD: Recent transcontinental sweep of Toxoplasma gondii driven by a single, monomorphic chromosome. Proc. Natl. Acad. Sci. USA, 2007, 104, 14872-14877.

  40. Taylor A, Barragan A, Su C, Fux B, Fentress SF, Tang K, Beatty WL, El Hajj H, Jerome M, Behnke MS,
    White M, Wootton JC, and Sibley LD: A secreted serine-threonine kinase determines virulence
    in the eukaryotic pathogen Toxoplasma gondii Science, 2006, 314, 1776-1780.


  41. Brossier F, Jewett TJ, Sibley LD, and Urban S: A spatially-localized rhomboid protease cleaves cell
    surface adhesions essential for invasion by Toxoplasma. Proc. Natl. Acad. Sci. (USA), 2005, 102: 4146-415.


  42. Sibley LD. Intracellular Parasite Invasion Strategies. Science, 2004, 304, 248-253.

  43. Su CL, Evans D, Cole RH, Kissinger JC, Ajioka JW, LD Sibley. Enhanced oral transmission acquired through recent recombination
    led to widespread expansion of Toxoplasma. Science, 2003, 299: 414-416.


  44. Jewett TJ, Sibley LD:Aldolase forms a bridge between cell surface adhesins and the actin cytoskeleton in apicomplexan parasites. Mol Cell. 2003 Apr;11(4):885-94.

  45. Su CL, Howe DK, Dubey JP, Ajioka J, LD Sibley. Acute virulence in Toxoplasma is mediated by several discrete loci common to the type I lineage. Proc. Natl. Acad. Sci. (USA), 2002, 99: 10753-10758.

  46. Barragan A, LD Sibley. Transepithelial migration of Toxoplasma gondii is linked to parasite motility and virulence. J. Exp. Med., 2002, 195: 1625-1633.

  47. Hªkansson S, Charron AJ, LD Sibley. Toxoplasma evacuoles: a two step process of secretion and fusion forms the parasitophorous
    vacuole. EMBO J. 2001, 20: 1-13.


    Dobrowolski J, and Sibley LD: Toxoplasma invasion of mammalian cells is powered by the parasite's actin cytoskeleton. Cell 1996;
    84: 933-939


  48. Sibley LD, and Boothroyd JC: Virulent strains of Toxoplasma gondii comprise a single clonal lineage. Nature (Lond.) 1992; 359:
    82-85


  49. Sibley LD, Weidner E, and Krahenbuhl JL: Phagosome acidification blocked by intracellular Toxoplasma gondii. Nature
    (Lond.) 1985; 315: 416-419
 

 

 
 

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