CURRICULUM VITAE
L. David Sibley

PubMed Publications: for sibley + LD
Division of Biology and Biomedical Sciences profile

Education:

1978	B.A., Oberlin College, Oberlin Ohio
1985	Ph.D., Louisiana State University, Baton Rouge. LA

Academic Positions:

2002-present	Professor, Department of Molecular Microbiology,Washington University School of Medicine, St. Louis, MO
1998-2002	Associate Professor Department of Molecular Microbiology,Washington University School of Medicine, St. Louis, MO
1991-1998	Assistant Professor Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO
1987-1991	Postdoctoral Research Fellow Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA
1985-1987	Research Scientist Laboratory Research Department, U.S.P.H.S., National Hansen's Disease Center, Carville, LA

Honors and Awards:

Selected Publications:

1. Sibley LD, Ajioka JW: Population structure of Toxoplasma gondii: clonal expansion driven by infrequent recombination and selective sweeps. Annu Rev Microbiol. 2008;62:329-51.
   
   
2. Nagamune K, Hicks LM, Fux B, Brossier F, Chini EN and Sibley LD: Abscisic acid controls calcium-dependent egress and development in Toxoplasma gondii. Nature, 2008, 451:207-210.
   
   
3. Dunay IR, Damatta RA, Fux B, Presti R, Greco SE, Collona M, and Sibley LD: Gr1+ (Ly6C+) inflammatory monocytes are required for mucosal resistance to the pathogen Toxoplasma gondii. Immunity, 2008, 29: 306-317.
   
   
4. Khan A, Fux BF, Su C, Dubey JP, Darde ML, Ajioka JW, Rosenthal BM, Sibley LD: Recent transcontinental sweep of Toxoplasma gondii driven by a single, monomorphic chromosome. Proc. Natl. Acad. Sci. USA, 2007, 104, 14872-14877.
   
   
5. Taylor A, Barragan A, Su C, Fux B, Fentress SF, Tang K, Beatty WL, El Hajj H, Jerome M, Behnke MS,
   White M, Wootton JC, and Sibley LD: A secreted serine-threonine kinase determines virulence
   in the eukaryotic pathogen Toxoplasma gondii Science, 2006, 314, 1776-1780.
   
   
6. Brossier F, Jewett TJ, Sibley LD, and Urban S: A spatially-localized rhomboid protease cleaves cell
   surface adhesions essential for invasion by Toxoplasma. Proc. Natl. Acad. Sci. (USA), 2005, 102: 4146-415.
   
   
7. Sibley LD. Intracellular Parasite Invasion Strategies. Science, 2004, 304, 248-253.
   
   
8. Su CL, Evans D, Cole RH, Kissinger JC, Ajioka JW, LD Sibley. Enhanced oral transmission acquired through recent recombination
   led to widespread expansion of Toxoplasma. Science, 2003, 299: 414-416.
   
   
9. Jewett TJ, Sibley LD:Aldolase forms a bridge between cell surface adhesins and the actin cytoskeleton in apicomplexan parasites. Mol Cell. 2003 Apr;11(4):885-94.
   
   
10. Su CL, Howe DK, Dubey JP, Ajioka J, LD Sibley. Acute virulence in Toxoplasma is mediated by several discrete loci common to the type I lineage. Proc. Natl. Acad. Sci. (USA), 2002, 99: 10753-10758.
    
    
11. Barragan A, LD Sibley. Transepithelial migration of Toxoplasma gondii is linked to parasite motility and virulence. J. Exp. Med., 2002, 195: 1625-1633.
    
    
12. Hªkansson S, Charron AJ, LD Sibley. Toxoplasma evacuoles: a two step process of secretion and fusion forms the parasitophorous
    vacuole. EMBO J. 2001, 20: 1-13.
    
    Dobrowolski J, and Sibley LD: Toxoplasma invasion of mammalian cells is powered by the parasite's actin cytoskeleton. Cell 1996;
    84: 933-939
    
    
13. Sibley LD, and Boothroyd JC: Virulent strains of Toxoplasma gondii comprise a single clonal lineage. Nature (Lond.) 1992; 359:
    82-85
    
    
14. Sibley LD, Weidner E, and Krahenbuhl JL: Phagosome acidification blocked by intracellular Toxoplasma gondii. Nature
    (Lond.) 1985; 315: 416-419