Curriculum Vitae
L. David Sibley


PubMed Publications: for sibley + LD
Division of Biology and Biomedical Sciences profile

Office Address: Department of Molecular Microbiology
Washington University School of Medicine
660 S. Euclid Ave.
St. Louis, MO 63110
Phone, office: (314)-362-8873
Phone, lab: (314)-362-8874
FAX: (314)-362-3203
Email: sibley [at] wustl.edu
   

 

 

Education:

1978 B.A., Oberlin College, Oberlin Ohio
1985 Ph.D., Louisiana State University, Baton Rouge. LA

 

Academic Positions:

2011-present Alan A. and Edith L. Wolff Distinguished Professor of Molecular Microbiology,
Washington University School of Medicine, St. Louis, MO
2002-2010 Professor,
Department of Molecular Microbiology,Washington University School of Medicine, St. Louis, MO
1998-2002 Associate Professor
Department of Molecular Microbiology,Washington University School of Medicine, St. Louis, MO
1991-1998 Assistant Professor
Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO
1987-1991 Postdoctoral Research Fellow
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA
1985-1987 Research Scientist
Laboratory Research Department, U.S.P.H.S., National Hansen's Disease Center, Carville, LA


Honors and Awards:

1982-1985 Louisiana State University Alumni Federation Predoctoral Fellowship
1988-1991 Merck Postdoctoral Fellowship, Stanford University
1993-1997 Burroughs Wellcome Fund New Investigator Award in Molecular Parasitology
1999-2000 Excellence in Mentoring Award, Graduate Student Senate, Washington University
2000-2005 Burroughs Wellcome Fund Scholar Award in Molecular Parasitology
2004-2005 Excellence in Mentoring Award, Graduate Student Senate, Washington University
2006- Alan Kaplan Lecture, University of Kentucky
2007- Fellow, American Academy of Microbiology
2007- Division AA Lecturer, American Society of Microbiology
2008- Molecular, Cellular, and Immunoparasitology Scientific Excellence Award, American Society of Tropical Medicine and Hygiene
2011- Howard T. Ricketts Lecture, University of Chicago
2011-2012 Distinguished Investigator Award, Washington University School of Medicine
2012- Norman D. Levine Lecture, University of Illinois
2010-2013 Excellence in Mentoring Award, Graduate Student Senate, Washington University
2012- Bruce A.D. Stocker Lecture, Stanford University School of Medicine
2014 Aikawa Memorial Lecture, Case Western Reserve University
2014 Thomson Reuters ISI Highly Cited Researchers List in Microbiology
2017 Alice and C.C. Wang Award In Parasitology, American Society for Biochemistry and Molecular Biology
2017

Member, National Academy of Science

 

Editorial, Advisory Boards, Review Panels:

2002-2006 Wellcome Trust Molecular Parasitology Unit, Glasgow, Scientific Advisory Board
2008-2016 Institut Pasteur, Scientific Advisory Council
1999-2014 Reviews Editor, Cellular Microbiology
2006-2010 Board of Reviewing Editors, Science
2006-2014 Associate Editor, PLoS Pathogens
2007-2010 Pathogenic Eukaryotes Study Section, NIH, Chairman (2008-2010)
2011-2015 Section Editor, Eukaryotic Cell
2012-2018 Board of Editors, mBio
2017-2020

Editorial Committee, Annual Review of Microbiology

 

Selected Publications:

  1. 1: Hakimi MA, Olias P, Sibley LD. Toxoplasma Effectors Targeting Host Signaling and Transcription. Clin Microbiol Rev. 2017 Jul;30(3):615-645. PMID: 28404792.

  2. 2: Olias P, Etheridge RD, Zhang Y, Holtzman MJ, Sibley LD. Toxoplasma Effector Recruits the Mi-2/NuRD Complex to Repress STAT1 Transcription and Block IFN-γ-Dependent Gene Expression. Cell Host Microbe. 2016 Jul 13;20(1):72-82.PubMed PMID: 27414498.

  3. 3: Behnke MS, Dubey JP, Sibley LD. Genetic Mapping of Pathogenesis Determinants in Toxoplasma gondii. Annu Rev Microbiol. 2016 Sep 8;70:63-81. PubMed PMID: 27359216.

  4. 4: Lorenzi H, Khan A, Behnke MS, Namasivayam S, Swapna LS, Hadjithomas M, Karamycheva S, Pinney D, Brunk BP, Ajioka JW, Ajzenberg D, Boothroyd JC, Boyle JP, Dardé ML, Diaz-Miranda MA, Dubey JP, Fritz HM, Gennari SM, Gregory BD, Kim K, Saeij JP, Su C, White MW, Zhu XQ, Howe DK, Rosenthal BM, Grigg ME, Parkinson J, Liu L, Kissinger JC, Roos DS, Sibley LD. Local admixture of amplified and diversified secreted pathogenesis determinants shapes mosaic Toxoplasma gondii genomes. Nat Commun. 2016 Jan 7;7:10147. PubMed PMID: 26738725.

  5. 5: Selleck EM, Orchard RC, Lassen KG, Beatty WL, Xavier RJ, Levine B, Virgin HW, Sibley LD. A Noncanonical Autophagy Pathway Restricts Toxoplasma gondii Growth in a Strain-Specific Manner in IFN-γ-Activated Human Cells. MBio. 2015 Sep 8;6(5):e01157-15. PubMed PMID: 26350966.

  6. 6: Drewry LL, Sibley LD. Toxoplasma Actin Is Required for Efficient Host Cell Invasion. MBio. 2015 Jun 16;6(3):e00557. PubMed PMID: 26081631.

  7. 7: Etheridge RD, Alaganan A, Tang K, Lou HJ, Turk BE, Sibley LD. The Toxoplasma pseudokinase ROP5 forms complexes with ROP18 and ROP17 kinases that synergize to control acute virulence in mice. Cell Host Microbe. 2014 May 14;15(5):537-50. PubMed PMID: 24832449.

  8. 8: Shen B, Brown KM, Lee TD, Sibley LD. Efficient gene disruption in diverse strains of Toxoplasma gondii using CRISPR/CAS9. MBio. 2014 May 13;5(3):e01114-14. PubMed PMID: 24825012.

  9. 9: Shen B, Sibley LD. Toxoplasma aldolase is required for metabolism but dispensable for host-cell invasion. Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3567-72. PubMed PMID: 24550496.

  10. 10: Alaganan A, Fentress SJ, Tang K, Wang Q, Sibley LD. Toxoplasma GRA7 effector increases turnover of immunity-related GTPases and contributes to acute virulence in the mouse. Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1126-31. PubMed PMID: 24390541.

  11. 11: Skillman KM, Ma CI, Fremont DH, Diraviyam K, Cooper JA, Sept D, Sibley LD. The unusual dynamics of parasite actin result from isodesmic polymerization. Nat Commun. 2013;4:2285. PubMed PMID: 23921463.

  12. 12: Lourido S, Zhang C, Lopez MS, Tang K, Barks J, Wang Q, Wildman SA, Shokat KM,
    Sibley LD. Optimizing small molecule inhibitors of calcium-dependent protein
    kinase 1 to prevent infection by Toxoplasma gondii. J Med Chem. 2013 Apr
    11;56(7):3068-77. PubMed PMID: 23470217.

  13. 13: Lourido S, Tang K, Sibley LD. Distinct signalling pathways control Toxoplasma egress and host-cell invasion. EMBO J. 2012 Dec 12;31(24):4524-34. PubMed PMID: 23149386.

  14. 14: Hunter CA, Sibley LD. Modulation of innate immunity by Toxoplasma gondii virulence effectors. Nat Rev Microbiol. 2012 Nov;10(11):766-78. PubMed PMID: 23070557.

  15. 15: Su C, Khan A, Zhou P, Majumdar D, Ajzenberg D, Dardé ML, Zhu XQ, Ajioka JW, Rosenthal BM, Dubey JP, Sibley LD. Globally diverse Toxoplasma gondii isolates comprise six major clades originating from a small number of distinct ancestral lineages. Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):5844-9. PubMed PMID: 22431627.

  16. 16: Behnke MS, Khan A, Wootton JC, Dubey JP, Tang K, Sibley LD. Virulence differences in Toxoplasma mediated by amplification of a family of polymorphic pseudokinases. Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9631-6. PubMed PMID: 21586633.

  17. 17: Sibley LD. Invasion and intracellular survival by protozoan parasites. Immunol Rev. 2011 Mar;240(1):72-91. PubMed PMID: 21349087.

  18. 18: Fentress SJ, Behnke MS, Dunay IR, Mashayekhi M, Rommereim LM, Fox BA, Bzik DJ, Taylor GA, Turk BE, Lichti CF, Townsend RR, Qiu W, Hui R, Beatty WL, Sibley LD. Phosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulence. Cell Host Microbe. 2010 Dec 16;8(6):484-95. PubMed PMID: 21147463.

  19. 19: Steinfeldt T, Könen-Waisman S, Tong L, Pawlowski N, Lamkemeyer T, Sibley LD, Hunn JP, Howard JC. Phosphorylation of mouse immunity-related GTPase (IRG) resistance proteins is an evasion strategy for virulent Toxoplasma gondii. PLoS Biol. 2010 Dec 21;8(12):e1000576. PubMed PMID: 21203588.

  20. 20: Lourido S, Shuman J, Zhang C, Shokat KM, Hui R, Sibley LD. Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma. Nature. 2010 May 20;465(7296):359-62. PubMed PMID: 20485436.

  21. 21: Wernimont AK, Artz JD, Finerty P Jr, Lin YH, Amani M, Allali-Hassani A, Senisterra G, Vedadi M, Tempel W, Mackenzie F, Chau I, Lourido S, Sibley LD, Hui R. Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium. Nat Struct Mol Biol. 2010 May;17(5):596-601. PMID: 20436473.

  22. 22: Billker O, Lourido S, Sibley LD. Calcium-dependent signaling and kinases in apicomplexan parasites. Cell Host Microbe. 2009 Jun 18;5(6):612-22. PubMed PMID: 19527888.

  23. 23: Zhao Z, Fux B, Goodwin M, Dunay IR, Strong D, Miller BC, Cadwell K, Delgado MA, Ponpuak M, Green KG, Schmidt RE, Mizushima N, Deretic V, Sibley LD, Virgin HW. Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens. Cell Host Microbe. 2008 Nov 13;4(5):458-69. PubMed PMID: 18996346.

  24. 24: Dunay IR, Damatta RA, Fux B, Presti R, Greco S, Colonna M, Sibley LD. Gr1(+) inflammatory monocytes are required for mucosal resistance to the pathogen Toxoplasma gondii. Immunity. 2008 Aug 15;29(2):306-17. PubMed PMID: 18691912.

  25. 25: Sibley LD, Ajioka JW. Population structure of Toxoplasma gondii: clonal expansion driven by infrequent recombination and selective sweeps. Annu Rev Microbiol. 2008;62:329-51. PubMed PMID: 18544039.