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CURRICULUM VITAE
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| Office Address: | Department of Molecular Microbiology |
Present Position:
2007 - Present Assistant Professor, Departments of Molecular Microbiology and Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO
Education/Training:
1999 - 2004 Ph. D. Biological Sciences, Watson School of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA 1995 - 1999 B.Sc. Biochemistry, Imperial College of Science, Technology and Medicine, London, UK.
Professional Experience and Appointments:
2007 - present
Assistant Professor, Departments of Molecular Microbiology and Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA
2004 - 2007
Postdoctoral Fellow, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA
Honors and Awards:
2010 Grants for New Investigators, Edward Mallinckrodt, Jr. Foundation 2006 Malaria: Functional Genomics to Biology to Medicine Meeting Scholarship, Keystone Symposia 1999-2004 Leslie Quick, Jr. Fellowship, Watson School of Biological Sciences 1999-2004 C. Ewart Stickings Memorial Prize. Distinction award from the Department of Biochemistry, Imperial College 1998 IMPACT Award, Pfizer Central Research award for innovation
University Service and Committees:
PhD Admissions Committee, The Division of Biology and Biomedical Sciences, Washington University, St. Louis, MO (2008, 2009, 2010, 2011) Course Master for the Infectious Diseases/Basic Microbiological Mechanisms Research Conference (2009, 2010, 2011)
Thesis Committees:
Priya Pal (Goldberg Lab) Aditi Alaganan (Sibley Lab) Kyle Austin (Fremont Lab) Sebastian Lorido (Sibley Lab) Tamira Butler (Goldberg Lab) Vincent Luca (Fremont Lab) Chung Lee (Fremont Lab)
Cara Mozola Pablo Tsukayama Christine Carle David Morales
Departmental Service:
Organized the Infectious Diseases/Basic Microbiological Mechanisms Research Conference (2009, 2010, 2011)
Teaching:
Lecturer in Special Topics in Microbial Pathogenesis (Biol 5217) (2009, 2010, 2011) Lecturer in Molecular Microbiology and Microbial Pathogenesis (Biol 5392) (2010, 2011)
Publications:
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Batchelor JD, Zahm JA, Tolia NH. "Dimerization of Plasmodium vivax DBP is induced upon receptor binding and drives recognition of DARC." Nature Structural & Molecular Biology (2011) Jul 10
Tolia NH, Enemark EJ, Sim BKL, Joshua-Tor L. “Structural basis for the EBA-175 erythrocyte invasion pathway of the malaria parasite P. falciparum.” Cell (2005) Jul 29; 122(2):183-93
Tolia NH, Joshua-Tor L. “Slicer and the Argonautes” Nature Chemical Biology (2007) Jan;3(1):36-43.
Yigit E, Batista PJ, Bei Y, Pang KM, Chen CG, Tolia NH, Joshua-Tor L, Mitani S, Simard MJ, Mello CC. “Analysis of the C. elegans Argonaute family reveals that distinct Argonautes act sequentially during RNAi” Cell (2006) Nov 17;127(4):747-757.
Irvine DV*, Zaratiegui M*, Tolia NH*, Goto DB, Chitwood DH, Vaughn MW, Joshua-Tor L, Martienssen RA “Argonaute slicing is required for heterochromatic silencing and spreading.” Science (2006) Aug 25; 313(5790):1134-7. *co-first authors
Tolia NH§, Joshua-Tor L. “Strategies for protein coexpression in Escherichia coli.” Nature Methods (2006) Jan; 3(1):55-64 §corresponding author
Rivas FV*, Tolia NH*, Song JJ*, Aragon JP, Liu J, Hannon GJ, Joshua-Tor L. “Purified Argonaute2 and an siRNA form recombinant human RISC.” Nature Structural & Molecular Biology (2005) Apr; 12(4):340-9. Epub Mar 30. *co-first authors
Song JJ, Liu J, Tolia NH, Schneiderman J, Smith SK, Martienssen RA, Hannon GJ, Joshua-Tor L. “The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes.” Nature Structural Biology (2003) Dec; 10(12):1026-32. Epub Nov 16.
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