Washington University School of Medicine
Department of Molecular Microbiology
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CURRICULUM VITAE
Niraj H. Tolia

PubMed Publications: for tolia + NH
Division of Biology and Biomedical Sciences profile

Office Address:

Department of Molecular Microbiology
Campus Box 8230, 660 S. Euclid Avenue
Washington University School of Medicine
St. Louis, Missouri 63110-1093
Tel: 314-286-0134 Fax: 314-362-1232
Email: tolia [at] wustl.edu

   

 

 

Present Position:

2007 - Present Assistant Professor, Departments of Molecular Microbiology and Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO

Education/Training:

1999 - 2004 Ph. D. Biological Sciences, Watson School of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor,  NY, USA
1995 - 1999 B.Sc. Biochemistry, Imperial College of Science, Technology and Medicine, London, UK.

Professional Experience and Appointments:

2007 - present

Assistant Professor, Departments of Molecular Microbiology and Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA

2004 - 2007

Postdoctoral Fellow, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA

Honors and Awards:

2010 Grants for New Investigators, Edward Mallinckrodt, Jr. Foundation
2006 Malaria: Functional Genomics to Biology to Medicine Meeting Scholarship, Keystone Symposia
1999-2004 Leslie Quick, Jr. Fellowship, Watson School of Biological Sciences
1999-2004 C. Ewart Stickings Memorial Prize. Distinction award from the Department of Biochemistry, Imperial College
1998 IMPACT Award, Pfizer Central Research award for innovation

University Service and Committees:

2008 - present PhD Admissions Committee, The Division of Biology and Biomedical Sciences, Washington University, St. Louis, MO
2012 - present Co-Chair PhD Admissions Committee, The Division of Biology and Biomedical Sciences, Washington University, St. Louis, MO
2009 - present Course Master for the Infectious Diseases/Basic Microbiological Mechanisms Research Conference

Thesis Committees:

Priya Pal (Goldberg Lab)
Aditi Alaganan (Sibley Lab)
Kyle Austin (Fremont Lab)
Sebastian Lorido (Sibley Lab)
Tamira Butler (Goldberg Lab)
Vincent Luca (Fremont Lab)
Chung Lee (Fremont Lab)

Departmental Service:

2009 - present Organized the Infectious Diseases/Basic Microbiological Mechanisms Research Conference

Teaching:

2009 - present Lecturer in Special Topics in Microbial Pathogenesis (Biol 5217)
2010 - present Lecturer in Molecular Microbiology and Microbial Pathogenesis (Biol 5392)

Publications:

    Brian M Malpede, Daniel H Lin, Niraj H Tolia. "Molecular Basis for Sialic Acid-dependent Receptor Recognition by Plasmodium falciparum Erythrocyte Binding Antigen 140/BAEBL." Journal of Biological Chemistry (2013) Mar 18

    Daniel H Lin, Brian M Malpede, Joseph D Batchelor, Niraj H Tolia. "Crystal and Solution Structures of Plasmodium falciparum Erythrocyte Binding Antigen 140 Reveal Determinants of Receptor Specificity during Erythrocyte Invasion." Journal of Biological Chemistry (2012) Oct 26;287(44):36830-6. doi: 10.1074/jbc.M112.409276. Epub 2012 Sep 18.

    Joseph D Batchelor, Jacob A Zahm, Niraj H Tolia. "Dimerization of Plasmodium vivax DBP is induced upon receptor binding and drives recognition of DARC." Nature Structural & Molecular Biology (2011) Jul 10;18(8):908-14

    Niraj H Tolia, Eric J Enemark, B Kim Lee Sim, Leemor Joshua-Tor. "Structural basis for the EBA-175 erythrocyte invasion pathway of the malaria parasite P. falciparum." Cell (2005) Jul 29; 122(2):183-93

    Niraj H Tolia, Leemor Joshua-Tor. "Slicer and the Argonautes" Nature Chemical Biology (2007) Jan;3(1):36-43.

    Erbay Yigit, Pedro J. Batista, Yanxia Bei, Ka Ming Pang, Chun-Chieh G. Chen, Niraj H Tolia, Leemor Joshua-Tor, Shohei Mitani, Martin J. Simard, Craig C Mello. "Analysis of the C. elegans Argonaute family reveals that distinct Argonautes act sequentially during RNAi" Cell (2006) Nov 17;127(4):747-757.

    Danielle V Irvine*, Mikel Zaratiegui*, Niraj H Tolia*, Derek B Goto, Daniel H Chitwood, Matthew W Vaughn, Leemor Joshua-Tor, Robert A Martienssen "Argonaute slicing is required for heterochromatic silencing and spreading." Science (2006) Aug 25; 313(5790):1134-7. *co-first authors

    Niraj H Tolia*, Leemor Joshua-Tor. "Strategies for protein coexpression in Escherichia coli." Nature Methods (2006) Jan; 3(1):55-64. *corresponding author

    Fabiola V Rivas*, Niraj H Tolia*, Ji-Joon Song*, Juan P Aragon, Jidong Liu, Gregory J Hannon, Leemor Joshua-Tor. "Purified Argonaute2 and an siRNA form recombinant human RISC." Nature Structural & Molecular Biology (2005) Apr; 12(4):340-9. Epub Mar 30. *co-first authors

    Ji-Joon Song, Jidong Liu, Niraj H Tolia, Jonathan Schneiderman J, Stephanie K Smith, Robert A Martienssen, Gregory J Hannon, Leemor Joshua-Tor. "The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes." Nature Structural Biology (2003) Dec; 10(12):1026-32. Epub Nov 16.

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