Assistant Professor of Molecular Microbiology

Kutluay Lab website

Research Interests:

Regulation of human immunodeficiency virus replication by viral and host RNA-binding proteins.

PubMed Publications: for Kutluay+SB
Division of Biology and Biomedical Sciences profile

Office Address:

Department of Molecular Microbiology
Washington University School of Medicine
Room 8220A, McDonnell Pediatric Research Building
Campus Box 8230
660 S. Euclid Ave.
St. Louis, MO 63110

Phone: 314-747-8908
Fax: 314-362-1232
Email: skutluay [at] wusm.wustl.edu

Education:

1999-2004 B.S. inBiological Science and Bioengineering Program (Major) & Chemistry (Minor), Faculty of Engineering and Natural Sciences (FENS), Sabanci University, Istanbul / TURKEY.
2004-2009 Ph.D. in Cell and Molecular Biology, Michigan State University, East Lansing, MI 48824-1319, USA.

Thesis Title: Regulation of chromatin during herpes simplex virus type-1 lytic infection. (Thesis Mentor: Steven J. Triezenberg)

Current Position:

Assistant Professor of Molecular Microbiology

Academic and Research Experience:

2015-present Assistant professor, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO.
2009-2014 Post-doctoral fellow in Dr. Paul Bieniasz’s laboratory at Aaron Diamond AIDS Research Center / Rockefeller University, New York, NY.

Honors and Awards:

2015-2017 NIH K22 Career Transition Award ($250,000). 
2014 Young Investigator Award at the Conference on Retroviruses and Opportunistic Infections, Boston, MA.           
2012-2014 American Foundation for AIDS Research (amfAR) Mathilde Krim Postdotoral Fellowship in Basic Biomedical Research ($125,000).
2008 Student award at American Society for Biochemistry and Molecular Biology meeting on “Transcriptional Regulation by Chromatin and RNA Polymerase II”, Lake Tahoe, CA.
2008 Travel grant from American Society for Microbiology for meeting on “Manipulation of Nuclear Processes by DNA viruses”, Charlotte, SC.
2007 Travel grant from Cell and Molecular Biology Graduate Program at Michigan State University for “International Herpesvirus Workshop”, Asheville, NC.
2006-2008 Predoctoral fellowship from the American Heart Association ($52,000).
2005-2006 Predoctoral fellowship from the College of Natural Science, Michigan State University, East Lansing, MI ($40,000).
1999-2004 Merit Scholarship (awarded to those students who rank in the top 0.05% in nationwide university entrance exam), Sabanci University, Istanbul / TURKEY.

Publications:

Kutluay, S.B., Zang, T., Blanco-Melo, D., Powell, C., Jannain, D., Errando, M., Bieniasz, P.D. 2014. Global changes in the RNA binding specificity of HIV-1 Gag regulate virion genesis. Cell 159(5): 1096-109.

Kane, M., Yadav, S., Bitzegeio, J., Kutluay, S.B., Zang, T., Wilson, S., Schoggins, J., Rice, C., Yamashita, M., Hatziioannou, T., Bieniasz, P.D. 2013. Mx2 is an interferon-induced inhibitor of HIV-1 infection. Nature 502(7472): 563-6.

Soll, S.J., Wilson, S.J., Kutluay, S.B., Hatziioannou, T., Bieniasz, P.D. 2013. Assisted evolution enables HIV-1 to overcome a high TRIM5α-imposed genetic barrier to rhesus macaque tropism. PLoS Pathogens 9(9): e1003667.

Kutluay, S.B., Perez-Caballero, D., Bieniasz, P.D. 2013. Fates of retroviral core components during unrestricted and TRIM5-restricted Infection.PLoS Pathogens 9(3): e1003214.

Wilson, S.J., Schoggins, J.W., Zang, T., Kutluay, S.B., Jouvenet, N., Alim, M.A., Bitzegeio, J., Rice, C.M., Bieniasz, P.D. 2012. Inhibition of HIV-1 particle assembly by 2′,3′-cyclic-nucleotide 3′-phosphodiesterase. Cell Host Microbe 12(4): 585-97.

Kutluay, S.B., and Bieniasz, P.D. 2010. Analysis of the initiating events in HIV-1 particle assembly and genome packaging. PLoS Pathogens 6(11):e1001200.

Kutluay, S.B., and Triezenberg, S.J. 2009. Regulation of chromatin during herpes simplex virus type-1 infections. Biochimica et Biophysica Acta 1790(6):456-66.

Kutluay, S.B., and Triezenberg, S.J. 2009.Regulation of histone deposition on the herpes simplex virus type-1 genome during lytic infection. Journal of Virology 83(11):5835-45.

Kutluay, S.B., DeVos, S., Klomp, J.E., Triezenberg, S.J. 2009. Transcriptional coactivators are not required for herpes simplex virus type-1 immediate early gene expression during lytic infection. Journal of Virology 83(8): 3436-49.

Kutluay, S.B., Doroghazi, J., Roemer, M.E., Triezenberg, S.J. 2008. Curcumin inhibits herpes simplex virus immediate-early gene expression by a mechanism independent of p300/CBP histone acetyltransferase activity. Virology 373 (2): 239-47.