Assistant Professor of Molecular Microbiology
Molecular mechanisms of rotavirus replication and pathogenesis; Virus-host interactions; Innate immune signaling in the intestinal epithelium.
PubMed Publications: for Siyuan Ding
Department of Molecular Microbiology
Washington University School of Medicine in St. Louis
4940 Parkview Place
McDonnell Pediatric Research Building, Rm 9220
St. Louis, MO 63110
Education and Positions:
2019-present Assistant Professor, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO
2018-2019 Instructor, Department of Medicine, Division of Gastroenterology and Hepatology, Stanford University, Palo Alto, CA07/2014-10/2018Postdoctoral fellow, Stanford University, Palo Alto, CA (Mentor: Dr. Harry B. Greenberg)
2009-2014 Ph.D. in Microbiology, Yale University, New Haven, CT (Mentor: Dr. Micheal D. Robek)
2005-2009 B.S. in Biological Science, Fudan University, Shanghai, China (Mentor: Dr. Jiang Zhong)
Honors and Awards:
07/2018-present NIH/NIAID K99/R00 Pathway to Independence Award
09/2018-present Instructor Support Program Award, Stanford Maternal & Child Health Research Institute
12/2016-12/2018 Early Career Award, Thrasher Research Fund
09/2016-08/2017 ‘Immunity, Transplantation and Infection’ Young Investigator Award, Stanford
08/2014-08/2017 Walter V. and Idun Berry Postdoctoral Fellowship, Stanford
09/2009-08/2012 Yale World Scholar Fellowship in Biomedical Science
06/2009 Summa Cum Laude, Bachelor of Science, Fudan University06/2008-05/2009FDUROP Scholar, Fudan University
Feng N, Hu L, Ding S, Ramani S, McNeal M, Yasukawa LL, Song Y, Prasad BVV, and Greenberg HB. (2019) Human VP8* antibodies neutralize rotavirus selectively in human intestinal epithelial cells. J Clin Invest. In Press.
Diep J, Ooi YS, Wilkinson AW, Peters CE, Foy E, Johnson JR, Zengel J, Ding S, Weng KF, Laufman O, Jang G, Young T, Verschuren E, Kobluk K, Sarnow P, Greenberg HB, Huttenhain R, Nagamine CM, Andino R, Krogan NJ, Gozani O, and Carette JE. Enterovirus pathogenesis requires the host methyltransferase SETD3. Nat Micro. In Press.
Ren L*, Ding S*#, Song Y*, Li B*, Co J, Ramanathan M, Amieva MR, Khavari PA, and Greenberg HB#. (2019) Profiling of rotavirus 3’UTR binding proteins reveals ATP synthase subunit ATP5B as a novel host factor that supports late stage virus replication. J Biol. Chem. Feb 15. pii: jbc.RA118.006004. doi: 10.1074/jbc.RA118.006004. * co-first authors, # co-corresponding authors
Ding S#, Zhu S, Ren L, Feng N, Song Y, Ge X, Li B, Flavell RA, and Greenberg HB#. (2018) Rotavirus VP3 targets MAVS for degradation to inhibit type III interferon expression in intestinal epithelial cells. Elife. Nov 21;7. pii: e39494. # co-corresponding authors
Ding S, Diep J, Feng N, Ren L, Li B, Ooi YS, Wang X, Brulois KF, Yasukawa LL, Li X, Kuo CJ, Solomon DA, Carette JE, and Greenberg HB. (2018) STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection. Nature Comm. Apr 16;9(1):1485.g
Zhong Z, Liang S, Sanchez-Lopez E, He F, Shalapour S, Lin X, Wong J, Ding S, Seki E, Schnabl B, Hevener A, Greenberg HB, Kisseleva T, and Karin M. (2018) New mitochondrial DNA synthesis enables NLRP3 inflammasome activation. Nature. 560(7717):198-203.
Zhu S*, Ding S*, Wang P, Wei Z, Yang Y, Li H, Pan W, Wang G, Lei X, Yu H, Palm NW, Zoete M, Zheng Y, Zhao J, Chen H, Zhao Y, Jurado K, Feng N, Shan L, Kluger Y, Lu J, Abraham C, Fikrig E, Greenberg HB, and Flavell RA. (2017) Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells. Nature. 546(7660):667-670. * co-first authors
Li B*, Ding S*#, Feng N, Mooney N, Ooi YS, Ren L, Diep J, Kelly MR, Yasukawa LL, Patton JT, Yamazaki H, Shirao T, Jackson PK, and Greenberg HB#. (2017) Drebrin restricts rotavirus entry by inhibiting dynamin-mediated endocytosis. PNAS. 114(18):E3642-3651. * co-first authors; # co-corresponding authors
Nair N, Feng N, Blum LK, Sanyal M, Ding S, Jiang B, Sen A, Morton JM, He XS, Robinson WH, and Greenberg HB. (2017) VP4- and VP7-specific antibodies mediate heterotypic immunity to rotavirus in humans. Sci Trans Med. 9(395).
Lumb JH, Li Q, Popov LM, Ding S, Keith M, Merrill BD, Greenberg HB, Li JB, and Carette JE. (2017) DDX represses aberrant activation of interferon-stimulated genes. Cell Reports. 20(4):819-831.
Ding S, Mooney N, Li B, Kelly MR, Feng N, Loktev AV, Sen A, Patton JT, Jackson PK, and Greenberg HB. (2016) Comparative proteomics reveals strain-specific β-TrCP degradation via rotavirus NSP1 hijacking a host Cullin-3-Rbx1 complex. PLoS Pathog. 12(10):e1005929.
Ding S and Robek MD. (2014) Peroxisomal MAVS activates IRF1-mediated IFN-λ production. Nat Immunol. 15(8):700-701. Ding S, Khoury-Hanold W, Iwasaki A, and Robek MD. (2014) Epigenetic reprogramming of the type III IFN response potentiates antiviral activity and suppresses tumor growth. PLoS Biol. 12(1):e1001758.
Bolen CR.*, Ding S*, Robek MD, and Kleinstein SH. (2014) Dynamic expression profiling of Type I and Type III Interferon-stimulated hepatocytes reveals a stable hierarchy of gene expression. Hepatology. 59(4):1262-1272. * co-first authors van den Pol AN, Ding S, and Robek MD. (2014) Long distance interferon signaling within the brain blocks virus spread. J Virol. 88(7):3695-3704.
07/2019 38th Annual Meeting for the American Society for Virology, Minneapolis
04/2019 5th Novel, Alternative Models for Enteric Diseases Consortium, Palo Alto
09/2018 2018 International dsRNA Virus Symposium, Houffalize, Belgium
07/2018 37th Annual Meeting for the American Society for Virology, College Park
04/2018 4th Novel, Alternative Models for Enteric Diseases Consortium, Houston
03/2018 Keystone Symposium: Intrinsic Defenses and Counterdefenses, Monterey
06/2017 36th Annual Meeting for the American Society for Virology, Madison
05/2017 3rd Novel, Alternative Models for Enteric Diseases Consortium, Cincinnati
10/2016 4th Annual Meeting of the International Cytokine and Interferon Society, San Francisco
06/2016 35th Annual Meeting for the American Society for Virology, Blacksburg
05/2016 2016 American Association of Immunologists Annual Meeting, Seattle
04/2015 Keystone Symposium: Innate Immunity and Microbial Pathogenesis, Lake Tahoe
10/2013 2013 International Meeting on Molecular Biology of HBV, Shanghai, China
Professional Activity and Peer Review:
2014-present Member, American Society for Virology
2014-present Reviewers for PLOS Pathogens, Journal of Virology, Virology, Journal of General Virology, Virus Research, Scientific Reports, etc.