Ernest St John Simms Distinguished Professor of Molecular Microbiology

Beverley Lab Website

Research Interests:

Molecular genetics and genomics of the protozoan parasite Leishmania major, including virulence in the insect and mammalian hosts, and strategies for control.

PubMed Publications: for Beverley + SM
Division of Biology and Biomedical Sciences profile

Office Address:

Departments of Molecular Microbiology
Washington University School of Medicine
8230 McDonnell Pediatric Research Building
Campus Box 8230
660 S. Euclid Ave.
St. Louis, MO 63110
Phone, office: 314-747-2630
FAX: 314-362-1232
Email: beverley [at] wustl.edu

Education:

1973 B.S. Department of Biology, California Institute of Technology
1979 Ph.D. University of California, Berkeley Ph.D.Biochemistry

Current Position:

Ernest St. John Simms Distinguished Professor in Molecular Microbiology, Washington University Medical School, St. Louis, MO 2018-present

Academic Positions and Employment:

2018-present Ernest St. John Simms Distinguished Professor in Molecular Microbiology, Washington University Medical School.
1997-2018 Head, Dept. of Molecular Microbiology, Washington University Medical School.
1997-2018 Director, Center for Infectious Disease Research, Washington University Medical School
1997-2018 Marvin A. Brennecke Professor in Molecular Microbiology, Washington University Medical School
1996-2003 Co-founder and Chief Scientist, Symbiontics Inc.
1995-1997 Acting Chair, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
1993-1997 Hsien Wu and Daisy Yen Wu Professorship in Biological Chemistry and Molecular Pharmacology, Harvard Medical School
1992-1997 Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
1988-1992 Associate Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
1983-1988 Assistant Professor of Pharmacology, Harvard Medical School
1981-1983 Postdoctoral Research Affiliate, Department of Biological Sciences, Stanford University (with R.T. Schimke)
1979-1981 Damon Runyon – Walter Winchell Postdoctoral Research Fellow, Department of Biological Sciences, Stanford University (with R.T. Schimke)

Selected Peer Reviewed Publications:
Inbar, E., J. Shaik, S.A. Iantorno, A. Romano, C. O. Nzelu, K.L. Owens, M. J. Sanders, D.E. Dobson, J. A. Cotton, M. E. Grigg, S. M. Beverley*, and D. L. Sacks*, (* authors contributed equally to this manuscript), “Whole genome sequencing of experimental hybrids reveals meiosis-like sexual recombination in Leishmania” (2019), PLoS Genetics 15(5):e1008042. PMCID:  PMC6519804.

Robinson, J.I. and S. M. Beverley (2018), “Concentration of 2’C-methyladenosine triphosphate by Leishmania guyanensis enables specific inhibition of the Leishmania RNA virus 1 polymerase”, J. Biol. Chem.293:6460-6469.   PMCID:  PMC5925801.

Grybchuk, D., N. S. Akopyants$, A. Y. Kostygov$, A. Konovalovas, L-F Lye, D. E. Dobson, H. Zangger, N. Fasel, A. Butenko, A. O. Frolov, J. Votýpka, C. M. d’Avila-Levy, P. Kulich, J. Moravcová, P. Plevka, I. B. Rogozin, S. Serva, J. Lukeš, S.M. Beverley*, and V. Yurchenko* (2018), “Viral discovery and diversity in trypanosomatid protozoa with a focus on relatives of the human parasite Leishmania”, Proc. Natl. Acad. Sci. USA 115(3):  E506-E515.  $,* authors contributed equally to this manuscript.  PMCID:  PMC5776999.

Guo, H., N. M. Novozhilova, G. Bandini, S.J. Turco, M. A. J. Ferguson and S. M. Beverley (2017), “Genetic Metabolic Complementation Establishes a Requirement for GDP-Fucose in Leishmania”, J. Biol. Chem. 292: 10696-10708.  PMCID:  PMC5481574.

Rossi, M, P. Castiglioni, M-A. Hartley, R. O. Eren, F. Prével, C. Desponds, D. T. Utzschneider, D. Zehn, M. G. Cusi, F. M. Kuhlmann, S. M. Beverley, C. Ronet, and N. Fasel (2017), “Type I interferons induced by endogenous or exogenous viral infections promote metastasis and relapse of leishmaniasis”, Proc. Natl. Acad. Sci. USA 114:  4987-4992.  PMCID:  PMC5441690.

Mandell, M.A. and S. M. Beverley (2017), “Continual renewal and replication of persistent Leishmania major parasites in concomitantly immune hosts”, Proc. Natl. Acad. Sci. USA 114:  E801-E810.  PMCID:  PMC5293024.

Kuhlmann, F.M. J.I. Robinson, G. Bluemling, C. Ronet, N. Fasel, and S.M. Beverley (2017), “Anti-viral Screening Identifies Adenosine Analogs Targeting the Endogenous dsRNA Leishmania RNA Virus 1 (LRV1) Pathogenicity Factor”, Proc. Natl. Acad. Sci. USA 114:  E811-E819.  PMCID:  PMC5293060.

Brettmann, E.A., J. Shaik, H. Zangger, L-F. Lye, F. M. Kuhlmann, N. S. Akopyants, D. M. Oschwald, K.L. Owens, S. M. Hickerson, C. Ronet, N. Fasel, and S. M. Beverley (2016), “Tilting the balance between RNA interference and replication eradicates Leishmania RNA virus 1 and mitigates the inflammatory response”, Proc. Natl. Acad. Sci. USA 113:11998-12005.  PMCID:  PMC5131895.

Romano, A., E. Inbar, A. Debrabant, M. Charmoy, P. Lawyer, F. Ribeiro-Gomes, M. Barhoumi, M. Grigg, J. Shaik, D. Dobson, S.M. Beverley* and D.L. Sacks* (2014), “Cross-species genetic exchange between visceral and cutaneous strains of Leishmania in the sand fly vector”,  Proc. Natl. Acad. Sci. USA 111:  16808-13.  PMCID:  PMC4250153.  * – senior authors contributed equally.

Atayde, V.D., H. Shi, J. Franklin, N.J. Carriero, T. Notton, L-F. Lye, K. Owens, S.M. Beverley, C. Tschudi and E. Ullu (2013), “The structure and repertoire of small interfering RNAs in Leishmania (Viannia) braziliensis reveal diversification in the trypanosomatid RNAi pathway”, Molecular Microbiology 87(3):580-93.  PMCID: PMC3556230.

Vickers, T.J. & S.M. Beverley, “Folate metabolic pathways in Leishmania” (2011), Essays in Biochemistry 51: 63–80. PMCID: PMC3278214.

Ives, A., C. Ronet, F. Prevel, G. Ruzzante, S. Fuertes-Marraco, F. Schutz, H. Zangger, M. Revaz-Breton, L-F. Lye, S.M. Hickerson, S.M. Beverley, H. Acha-Orbea, P. Launois, N. Fasel and S. Masina (2011), “Leishmania RNA Virus controls the severity of Leishmaniasis” Science 331: 775-778.   PMCID: PMC3253482.

Lye, L-F., K. L. Owens, H. Shi, S.M.F. Murta, A.C. Vieira, S.J. Turco, C. Tschudi, E. Ullu, and S.M. Beverley (2010), “Retention and loss of RNA interference pathways in Trypanosomatid protozoans”, PLoS Pathogens 6:  e1001161.  PMCID: PMC2965760

Madeira da Silva, L. and S. M. Beverley (2010), “Expansion of the TOR kinase family and function in Leishmania: TOR3 is required for acidocalcisome biogenesis and animal infectivity” Proc. Natl. Acad. Sci. USA 107:  11965-11970.  PMCID:  PMC2900677

Zhang, K. and S. M. Beverley (2010),Phospholipid and sphingolipid metabolism in Leishmania”, Molecular & Biochemical Parasitology 170 (2010) 55–64. PMCID: PMC2815228

Madeira da Silva, L., K.L. Owens, S.F.M. Murta, and S.M. Beverley (2009), “Regulated expression of the Leishmania major surface virulence factor lipophosphoglycan using conditionally destabilized fusion proteins”, Proc. Natl. Acad. Sci. USA 106:.7583-7588.    PMCID: PMC2678649.

Akopyants*, N., N. Kimblin*, N. Secondino, R. Patrick, P. Lawyer, D.E. Dobson, S.M. Beverley*, and D.L. Sacks* (2009), “Demonstration of genetic exchange during cyclical development of Leishmania in the sand fly vector”, Science 324: 265-268.  PMCID: PMC2729066   (*1st two authors contributed equally; last two authors contributed equally).    (see commentary “Leishmania exploit sex”, Miles, M.A., M. Yeo, and I.L. Mauricio (2009) Science 324: 187-189).

Uzonna, J., G. Späth, S. M. Beverley, and P. Scott (2004), “Vaccination with phosphoglycan-deficient lpg2– knockout Leishmania major protects highly susceptible mice from virulent challenge”, J. Immunology 172:  3793-7.

Späth, G., L-F. Lye, H. Segawa, D. L. Sacks, S. J. Turco, and S. M. Beverley (2003), “Persistence without pathology in phosphoglycan-deficient Leishmania major”, Science 301: 1241-3. 

Späth, G., L. A. Garraway, S. J. Turco, and S. M. Beverley (2003), “The role(s) of lipophosphoglycan (LPG) in the establishment of Leishmania major infections in mammalian hosts”, Proc. Natl. Acad. Sci. U.S.A. 100:  9536-41.

Späth, G.F., L. Epstein, B. Leader, S.M. Singer, H.A. Avila, S.J. Turco and S.M. Beverley (2000), “Lipophosphoglycan is a virulence factor distinct from related glycoconjugates in the protozoan parasite Leishmania major”, Proc. Natl. Acad. Sci. USA 97:  9258-9263.

Sacks, D.L., G. Modi, E. Rowton, G. Späth, L. Epstein, S.J. Turco and S.M. Beverley (2000), “The role of phosphoglycans in Leishmania – sand fly interactions”, Proc. Natl. Acad. Sci. U. S. A. 97:  406-11. Cotrim, P.C., L.K. Garrity, and S.M. Beverley (1999), “Isolation of genes mediating resistance to inhibitors of nucleoside and ergosterol metabolism in Leishmania by over-expression/selection”, J. Biol. Chem. 274:  37723-37730.