Recent publications

Old vaccines for new infections: Exploiting innate immunity to control COVID-19 and prevent future pandemics. Chumakov K, Avidan MS, Benn CS, Bertozzi SM, Blatt L, Chang AY, Jamison DT, Khader SA, Kottilil S, Netea MG, Sparrow A, Gallo RC. Proc Natl Acad Sci U S A. 2021 May 25;118(21):e2101718118. doi: 10.1073/pnas.2101718118. PMID: 34006644.

Cryo-EM structure of cortical microtubules from human parasite Toxoplasma gondii identifies their microtubule inner proteins. Wang X, Fu Y, Beatty WL, Ma M, Brown A, David Sibley L, Zhang R. Nat Commun. 2021 May 24;12(1):3065. doi: 10.1038/s41467-021-23351-1. PMID: 34031406.

Trained immunity, tolerance, priming and differentiation: distinct immunological processes. Divangahi M, Aaby P, Khader SA, Barreiro LB, Bekkering S, Chavakis T, van Crevel R, Curtis N, DiNardo AR, Dominguez-Andres J, Duivenvoorden R, Fanucchi S, Fayad Z, Fuchs E, Hamon M, Jeffrey KL, Khan N, Joosten LAB, Kaufmann E, Latz E, Matarese G, van der Meer JWM, Mhlanga M, Moorlag SJCFM, Mulder WJM, Naik S, Novakovic B, O’Neill L, Ochando J, Ozato K, Riksen NP, Sauerwein R, Sherwood ER, Schlitzer A, Schultze JL, Sieweke MH, Benn CS, Stunnenberg H, Sun J, van de Veerdonk FL, Weis S, Williams DL, Xavier R, Netea MG. Nat Immunol. 2021 Jan;22(1):2-6. doi: 10.1038/s41590-020-00845-6. Erratum in: Nat Immunol. 2021 May 20; PMID: 33293712; PMCID: PMC8020292.

Toxoplasma gondii secreted effectors co-opt host repressor complexes to inhibit necroptosis. Rosenberg A, Sibley LD. Cell Host Microbe. 2021 May 20:S1931-3128(21)00192-X. doi: 10.1016/j.chom.2021.04.016. Epub ahead of print. PMID: 34043960.

Broadly neutralizing monoclonal antibodies protect against multiple tick-borne flaviviruses. VanBlargan LA, Errico JM, Kafai NM, Burgomaster KE, Jethva PN, Broeckel RM, Meade-White K, Nelson CA, Himansu S, Wang D, Handley SA, Gross ML, Best SM, Pierson TC, Fremont DH, Diamond MS. J Exp Med. 2021 May 3;218(5):e20210174. doi: 10.1084/jem.20210174. PMID: 33831142; PMCID: PMC8040518.

Detection of respiratory syncytial virus defective genomes in nasal secretions is associated with distinct clinical outcomes. Felt SA, Sun Y, Jozwik A, Paras A, Habibi MS, Nickle D, Anderson L, Achouri E, Feemster KA, Cárdenas AM, Turi KN, Chang M, Hartert TV, Sengupta S, Chiu C, López CB. Nat Microbiol. 2021 May;6(5):672-681. doi: 10.1038/s41564-021-00882-3. PMID: 33795879.

N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2. McCallum M, De Marco A, Lempp FA, Tortorici MA, Pinto D, Walls AC, Beltramello M, Chen A, Liu Z, Zatta F, Zepeda S, di Iulio J, Bowen JE, Montiel-Ruiz M, Zhou J, Rosen LE, Bianchi S, Guarino B, Fregni CS, Abdelnabi R, Foo SC, Rothlauf PW, Bloyet LM, Benigni F, Cameroni E, Neyts J, Riva A, Snell G, Telenti A, Whelan SPJ, Virgin HW, Corti D, Pizzuto MS, Veesler D. Cell. 2021 Apr 29;184(9):2332-2347.e16. doi: 10.1016/j.cell.2021.03.028. PMID: 33761326; PMCID: PMC7962585.

Phenotype of Peripheral NK Cells in Latent, Active, and Meningeal Tuberculosis. Choreño-Parra JA, Jiménez-Álvarez LA, Maldonado-Díaz ED, Cárdenas G, Fernández-Lopez LA, Soto-Hernandez JL, Muñoz-Torrico M, Ramírez-Martínez G, Cruz-Lagunas A, Vega-López A, Domínguez-López ML, Sánchez-Garibay C, Guadarrama-Ortíz P, Giono S, Jiménez-Zamudio LA, Khader SA, García-Latorre EA, Salinas-Lara C, Zúñiga J. J Immunol Res. 2021 Apr 27;2021:5517856. doi: 10.1155/2021/5517856. PMID: 34007850; PMCID: PMC8100419.

SARS-CoV-2 E gene variant alters analytical sensitivity characteristics of viral detection using a commercial RT-PCR assay. Tahan S, Parikh BA, Droit L, Wallace MA, Burnham CA, Wang D. J Clin Microbiol. 2021 Apr 26:JCM.00075-21. doi: 10.1128/JCM.00075-21. PMID: 33903167.

Clinical and Immunological Factors That Distinguish COVID-19 From Pandemic Influenza A(H1N1). Choreño-Parra JA, Jiménez-Álvarez LA, Cruz-Lagunas A, Rodríguez-Reyna TS, Ramírez-Martínez G, Sandoval-Vega M, Hernández-García DL, Choreño-Parra EM, Balderas-Martínez YI, Martinez-Sánchez ME, Márquez-García E, Sciutto E, Moreno-Rodríguez J, Barreto-Rodríguez JO, Vázquez-Rojas H, Centeno-Sáenz GI, Alvarado-Peña N, Salinas-Lara C, Sánchez-Garibay C, Galeana-Cadena D, Hernández G, Mendoza-Milla C, Domínguez A, Granados J, Mena-Hernández L, Pérez-Buenfil LÁ, Domínguez-Cheritt G, Cabello-Gutiérrez C, Luna-Rivero C, Salas-Hernández J, Santillán-Doherty P, Regalado J, Hernández-Martínez A, Orozco L, Ávila-Moreno F, García-Latorre EA, Hernández-Cárdenas CM, Khader SA, Zlotnik A, Zúñiga J. Front Immunol. 2021 Apr 21;12:593595. doi: 10.3389/fimmu.2021.593595. PMID: 33995342; PMCID: PMC8115405.

Too much of a good thing: Overproduction of virulence factors impairs cryptococcal pathogenicity.  Reuwsaat JCV, Doering TL, Kmetzsch L.. Microb Cell. 2021 Apr 20;8(5):108-110. doi: 10.15698/mic2021.05.750. PMID: 33981763; PMCID: PMC8080896.

Monocyte progenitors give rise to multinucleated giant cells. Lösslein AK, Lohrmann F, Scheuermann L, Gharun K, Neuber J, Kolter J, Forde AJ, Kleimeyer C, Poh YY, Mack M, Triantafyllopoulou A, Dunlap MD, Khader SA, Seidl M, Hölscher A, Hölscher C, Guan XL, Dorhoi A, Henneke P. Nat Commun. 2021 Apr 1;12(1):2027. doi: 10.1038/s41467-021-22103-5. PMID: 33795674; PMCID: PMC8016882.

Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies. Chen RE, Zhang X, Case JB, Winkler ES, Liu Y, VanBlargan LA, Liu J, Errico JM, Xie X, Suryadevara N, Gilchuk P, Zost SJ, Tahan S, Droit L, Turner JS, Kim W, Schmitz AJ, Thapa M, Wang D, Boon ACM, Presti RM, O’Halloran JA, Kim AHJ, Deepak P, Pinto D, Fremont DH, Crowe JE Jr, Corti D, Virgin HW, Ellebedy AH, Shi PY, Diamond MS. Nat Med. 2021 Apr;27(4):717-726. doi: 10.1038/s41591-021-01294-w. PMID: 33664494; PMCID: PMC8058618.

The antioxidant response favors Leishmania parasites survival, limits inflammation and reprograms the host cell metabolism. Reverte M, Eren RO, Jha B, Desponds C, Snäkä T, Prevel F, Isorce N, Lye LF, Owens KL, Gazos Lopes U, Beverley SM, Fasel N. PLoS Pathog. 2021 Mar 25;17(3):e1009422. doi: 10.1371/journal.ppat.1009422. PMID: 33765083; PMCID: PMC7993605.

CARD8 is an inflammasome sensor for HIV-1 protease activity. Wang Q, Gao H, Clark KM, Mugisha CS, Davis K, Tang JP, Harlan GH, DeSelm CJ, Presti RM, Kutluay SB, Shan L. Science. 2021 Mar 19;371(6535):eabe1707. doi: 10.1126/science.abe1707. PMID: 33542150; PMCID: PMC8029496.

N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2. McCallum M, De Marco A, Lempp FA, Tortorici MA, Pinto D, Walls AC, Beltramello M, Chen A, Liu Z, Zatta F, Zepeda S, di Iulio J, Bowen JE, Montiel-Ruiz M, Zhou J, Rosen LE, Bianchi S, Guarino B, Fregni CS, Abdelnabi R, Foo SC, Rothlauf PW, Bloyet LM, Benigni F, Cameroni E, Neyts J, Riva A, Snell G, Telenti A, Whelan SPJ, Virgin HW, Corti D, Pizzuto MS, Veesler D. N. Cell. 2021 Apr 29;184(9):2332-2347.e16. doi: 10.1016/j.cell.2021.03.028. Epub 2021 Mar 16. PMID: 33761326; PMCID: PMC7962585.

Identification of SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization. Liu Z, VanBlargan LA, Bloyet LM, Rothlauf PW, Chen RE, Stumpf S, Zhao H, Errico JM, Theel ES, Liebeskind MJ, Alford B, Buchser WJ, Ellebedy AH, Fremont DH, Diamond MS, Whelan SPJ. Cell Host Microbe. 2021 Mar 10;29(3):477-488.e4. doi: 10.1016/j.chom.2021.01.014. PMID: 33535027; PMCID: PMC7839837.

The Transcription Factor Pdr802 Regulates Titan Cell Formation and Pathogenicity of Cryptococcus neoformans. Reuwsaat JCV, Agustinho DP, Motta H, Chang AL, Brown H, Brent MR, Kmetzsch L, Doering TL. mBio. 2021 Mar 9;12(2):e03457-20. doi: 10.1128/mBio.03457-20. PMID: 33688010; PMCID: PMC8092302.

Insulinase-like Protease 1 Contributes to Macrogamont Formation in Cryptosporidium parvum. Xu R, Feng Y, Xiao L, Sibley LD. mBio. 2021 Mar 9;12(2):e03405-20. doi: 10.1128/mBio.03405-20. PMID: 33688009; PMCID: PMC8092296.

IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection. Rosa BA, Ahmed M, Singh DK, Choreño-Parra JA, Cole J, Jiménez-Álvarez LA, Rodríguez-Reyna TS, Singh B, Gonzalez O, Carrion R Jr, Schlesinger LS, Martin J, Zúñiga J, Mitreva M, Khader SA, Kaushal D. Commun Biol. 2021 Mar 5;4(1):290. doi: 10.1038/s42003-021-01829-4. PMID: 33674719; PMCID: PMC7935909.

Responses to acute infection with SARS-CoV-2 in the lungs of rhesus macaques, baboons and marmosets. Singh DK, Singh B, Ganatra SR, Gazi M, Cole J, Thippeshappa R, Alfson KJ, Clemmons E, Gonzalez O, Escobedo R, Lee TH, Chatterjee A, Goez-Gazi Y, Sharan R, Gough M, Alvarez C, Blakley A, Ferdin J, Bartley C, Staples H, Parodi L, Callery J, Mannino A, Klaffke B, Escareno P, Platt RN 2nd, Hodara V, Scordo J, Gautam S, Vilanova AG, Olmo-Fontanez A, Schami A, Oyejide A, Ajithdoss DK, Copin R, Baum A, Kyratsous C, Alvarez X, Ahmed M, Rosa B, Goodroe A, Dutton J, Hall-Ursone S, Frost PA, Voges AK, Ross CN, Sayers K, Chen C, Hallam C, Khader SA, Mitreva M, Anderson TJC, Martinez-Sobrido L, Patterson JL, Turner J, Torrelles JB, Dick EJ Jr, Brasky K, Schlesinger LS, Giavedoni LD, Carrion R Jr, Kaushal D. Author Correction: Nat Microbiol. 2021 Mar;6(3):413. doi: 10.1038/s41564-021-00867-2. Erratum for: Nat Microbiol. 2021 Jan;6(1):73-86. PMID: 33462437; PMCID: PMC7812341.

IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection. Rosa BA, Ahmed M, Singh DK, Choreño-Parra JA, Cole J, Jiménez-Álvarez LA, Rodríguez-Reyna TS, Singh B, Gonzalez O, Carrion R Jr, Schlesinger LS, Martin J, Zúñiga J, Mitreva M, Kaushal D, Khader SA. Commun Biol. 2021 Mar 5;4(1):290. doi: 10.1038/s42003-021-01829-4. PMID: 33674719; PMCID: PMC7935909.

Expression of Surfactant protein D (SP-D) distinguishes severe pandemic influenza A(H1N1) from COVID-19. Choreño-Parra JA, Jiménez-Álvarez LA, Ramírez-Martínez G, Cruz-Lagunas A, Thapa M, Fernández-López LA, Carnalla-Cortés M, Choreño-Parra EM, Mena-Hernández L, Sandoval-Vega M, Hernández-Montiel EM, Hernández-García DL, Ramírez-Noyola JA, Reyes-López CE, Domínguez-Faure A, Zamudio-López GY, Márquez-García E, Moncada-Morales A, Mendoza-Milla C, Cervántes-Rosete D, Muñoz-Torrico M, Luna-Rivero C, García-Latorre EA, Guadarrama-Ortíz P, Ávila-Moreno F, Domínguez-Cherit G, Rodríguez-Reyna TS, Mudd PA, Hernández-Cárdenas CM, Khader SA, Zúñiga J. J Infect Dis. 2021 Mar 1:jiab113. doi: 10.1093/infdis/jiab113. Epub ahead of print. PMID: 33668070; PMCID: PMC7989215.

Endogenization of a Prosimian Retrovirus during Lemur Evolution. Apakupakul K, Deem SL, Maqsood R, Sithiyopasakul P, Wang D, Lim ES. Viruses. 2021 Feb 27;13(3):383. doi: 10.3390/v13030383. PMID: 33673677; PMCID: PMC7997422.

CXCL17 Is a Specific Diagnostic Biomarker for Severe Pandemic Influenza A(H1N1) That Predicts Poor Clinical Outcome. Choreño-Parra JA, Jiménez-Álvarez LA, Ramírez-Martínez G, Sandoval-Vega M, Salinas-Lara C, Sánchez-Garibay C, Luna-Rivero C, Hernández-Montiel EM, Fernández-López LA, Cabrera-Cornejo MF, Choreño-Parra EM, Cruz-Lagunas A, Domínguez A, Márquez-García E, Cabello-Gutiérrez C, Bolaños-Morales FV, Mena-Hernández L, Delgado-Zaldivar D, Rebolledo-García D, Guadarrama-Ortiz P, Regino-Zamarripa NE, Mendoza-Milla C, García-Latorre EA, Rodiguez-Reyna TS, Cervántes-Rosete D, Hernández-Cárdenas CM, Khader SA, Zlotnik A, Zúñiga J. Front Immunol. 2021 Feb 26;12:633297. doi: 10.3389/fimmu.2021.633297. PMID: 33717172; PMCID: PMC7953906.

Toxoplasma gondii infection and its implications within the central nervous system. Matta SK, Rinkenberger N, Dunay IR, Sibley LD. Nat Rev Microbiol. 2021 Feb 24. doi: 10.1038/s41579-021-00518-7. Epub ahead of print. PMID: 33627834.

Limited effects of long-term daily cranberry consumption on the gut microbiome in a placebo-controlled study of women with recurrent urinary tract infections. Straub TJ, Chou WC, Manson AL, Schreiber HL 4th, Walker BJ, Desjardins CA, Chapman SB, Kaspar KL, Kahsai OJ, Traylor E, Dodson KW, Hullar MAJ, Hultgren SJ, Khoo C, Earl AM. BMC Microbiol. 2021 Feb 18;21(1):53. doi: 10.1186/s12866-021-02106-4. PMID: 33596852; PMCID: PMC7890861.

The immune landscape in tuberculosis reveals populations linked to disease and latency. Esaulova E, Das S, Singh DK, Choreño-Parra JA, Swain A, Arthur L, Rangel-Moreno J, Ahmed M, Singh B, Gupta A, Fernández-López LA, de la Luz Garcia-Hernandez M, Bucsan A, Moodley C, Mehra S, García-Latorre E, Zuniga J, Atkinson J, Kaushal D, Artyomov MN, Khader SA. Cell Host Microbe. 2021 Feb 10;29(2):165-178.e8. doi: 10.1016/j.chom.2020.11.013. PMID: 33340449; PMCID: PMC7878437.

Seroprevalence of SARS-CoV-2 Antibodies in Children and Adults in St. Louis, Missouri, USA. Smith BK, Janowski AB, Danis JE, Harvey IB, Zhao H, Dai YN, Farnsworth CW, Gronowski AM, Roper S, Fremont DH, Wang D. mSphere. 2021 Feb 3;6(1):e01207-20. doi: 10.1128/mSphere.01207-20. PMID: 33536325; PMCID: PMC7860990.

A host receptor enables type 1 pilus-mediated pathogenesis of Escherichia coli pyelonephritis.  McLellan LK, McAllaster MR, Kim AS, Tóthová Ľ, Olson PD, Pinkner JS, Daugherty AL, Hreha TN, Janetka JW, Fremont DH, Hultgren SJ, Virgin HW, Hunstad DA. PLoS Pathog. 2021 Jan 29;17(1):e1009314. doi: 10.1371/journal.ppat.1009314. PMID: 33513212; PMCID: PMC7875428.

Leishmania Sexual Reproductive Strategies as Resolved through Computational Methods Designed for Aneuploid Genomes. Genes (Basel). Shaik JS, Dobson DE, Sacks DL, Beverley SM.  2021 Jan 26;12(2):167. doi: 10.3390/genes12020167. PMID: 33530584; PMCID: PMC7912377.

Perspectives and Advances in the Understanding of Tuberculosis. Kinsella RL, Zhu DX, Harrison GA, Mayer Bridwell AE, Prusa J, Chavez SM, Stallings CL. Annu Rev Pathol. 2021 Jan 24;16:377-408. doi: 10.1146/annurev-pathol-042120-032916. PMID: 33497258.

Mycobacterium tuberculosis Rv3160c is a TetR-like transcriptional repressor that regulates expression of the putative oxygenase Rv3161c. Tükenmez H, Sarkar S, Anoosheh S, Kruchanova A, Edström I, Harrison GA, Stallings CL, Almqvist F, Larsson C. Sci Rep. 2021 Jan 15;11(1):1523. doi: 10.1038/s41598-021-81104-y. PMID: 33452380; PMCID: PMC7810876.

Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding Domain that Escape Antibody Recognition. Greaney AJ, Starr TN, Gilchuk P, Zost SJ, Binshtein E, Loes AN, Hilton SK, Huddleston J, Eguia R, Crawford KHD, Dingens AS, Nargi RS, Sutton RE, Suryadevara N, Rothlauf PW, Liu Z, Whelan SPJ, Carnahan RH, Crowe JE Jr, Bloom JD. Cell Host Microbe. 2021 Jan 13;29(1):44-57.e9. doi: 10.1016/j.chom.2020.11.007. PMID: 33259788; PMCID: PMC7676316.

SARS-CoV-2 Viral RNA Shedding for More Than 87 Days in an Individual With an Impaired CD8+ T Cell Response. Turner JS, Day A, Alsoussi WB, Liu Z, O’Halloran JA, Presti RM, Patterson BK, Whelan SPJ, Ellebedy AH, Mudd PA. Front Immunol. 2021 Jan 8;11:618402. doi: 10.3389/fimmu.2020.618402. PMID: 33488630; PMCID: PMC7820941.

UFMylation inhibits the proinflammatory capacity of interferon-γ-activated macrophages. Balce DR, Wang YT, McAllaster MR, Dunlap BF, Orvedahl A, Hykes BL Jr, Droit L, Handley SA, Wilen CB, Doench JG, Orchard RC, Stallings CL, Virgin HW. Proc Natl Acad Sci U S A. 2021 Jan 5;118(1):e2011763118. doi: 10.1073/pnas.2011763118. PMID: 33372156; PMCID: PMC7817147.