Microbiology Seminar Series Archive | Department of Molecular Microbiology | Washington University in St. Louis

Microbiology Seminar Series

Fall 2022

20 Sept	Ana Flores Mireles	University of Notre Dame	Deficiencies in the fibrinolytic system predisposes the host to develop a catheter-associated urinary tract infection	Michael Caparon
27 Sept	Michele LeRoux	Washington University in St. Louis	Toxin-antitoxin systems mediate bacterial immunity to phage
4 Oct	Ali Ellebedy	Washington University of St. Louis	B Cell Response to mRNA Vaccination in Humans: Learning from ‘Experiments of Nature’
11 Oct	Damian J Krysan	University of Iowa	Genetic Interaction Analysis of Fungal Pathogens	Tamara Doering
18 Oct	M. Stephen Trent	University of Georgia	Pushing the Envelope: Building and Maintaining the Gram-negative Outer Membrane	Mario Feldman
25 Oct	William McCoy	Washington University in St. Louis	Acne, Antibiotics, and Arthroplasties	Siyuan Ding
1 Nov	Photini Sinnis	Johns Hopkins University	The Establishment of Malaria Infection: Parasite Bottleneck and Point for Intervention	Daniel Goldberg
8 Nov	Rachel Fearns	Boston University	Interplay between cellular nucleotide biosynthesis and pneumovirus transcription and genome replication	Sebastien Felt, Postdoc
15 Nov	Vern Carruthers	University of Michigan	Toxoplasma strategically exploits host ESCRTs for nutrient salvage from infected cells	David Sibley
22 Nov	Aaron Schmidt	Harvard Medical School	Eliciting antibodies to conserved viral sites and their role in viral evolution	Sean Whelan
29 Nov	Sanjay Ram	University of Massachusetts Chan Medical School	Harnessing virulence factors to develop vaccines and immunotherapies against Neisseria gonorrhoeae	Hrishikesh Kulkarni
6 Dec	Shumin Tan	Tufts University	Illuminating Mycobacterium tuberculosis exploitation of environmental ionic cues during infection	Jen Philips
13 Dec	Harry B. Greenberg	Stanford University	Rotavirus pathogenesis and immunity	Siyuan Ding

Spring 2022

11 Jan	Nathan Sherer	University of Wisconsin	Single-cell dynamics of HIV-1 gene expression and virion production	Sebla Kutluay
18 Jan	Stephen Lory	Harvard	Regulation of Pseudomonas aeruginosa virulence and antibiotic resistance by small non-coding RNAs	Phil Tarr and Sean Whelan
25 Jan	Kartik Chandran	Albert Einstein College of Medicine	Dissecting and Disabling the Spike Proteins of Enveloped Viruses	Sean Whelan
1 Feb	Cynthia Sears	Johns Hopkins	Unraveling the mechanisms of biofilms in CRC	Andy Kau
8 Feb	Karine Gibbs	UC Berkeley	Micro-crowdsourcing: how swarming bacteria integrate signals to build communities	Forrest Walker
15 Feb	Elina Zuniga	UC San Diego	Induction and Exhaustion of Interferons After Viral Infection	Shabaana Khader
22 Feb	Ben Garcia	WashU	Mass spectrometry based proteomics for understanding viral infections
1 Mar	Sebastian Winter	UT Southwestern	Canceled	Mario Feldman
1 Mar	Mario Feldman	WashU	Dissecting the virulence strategies of Acinetobacter baumannii
8 Mar	Joe DeRisi	UCSF/Biohub	Pandemic Stories at the intersection of Basic Science and Public Health	David Wang
15 Mar	Michael Bachman	University of Michigan	Klebsiella Pathogenesis: Colonization, Infection, and the Accessory Genome	David Rosen
22 Mar	John D. MacMicking	Yale University School of Medicine	Biological Systems of Cell Defense: New Nanomachines for Immunity to Infection	Siyuan Ding
29 Mar	Maziar Divangahi	McGill University	The nuts and bolts of macrophages in pulmonary infectious diseases	Shabaana Khader
5 Apr	Rita Tamayo	U of NC Chapel Hill	Mechanisms and functions of phenotypic heterogeneity in Clostridioides difficile	Mario Feldman
12 Apr	Beatriz Fontoura	UT Southwestern	Viral-Host Interactions with Intranuclear Pathways	Jacco Boon
19 Apr	Peggy Cotter	UNC	Bordetella filamentous hemagglutinin: a phagocyte-specific toxin delivery system?	Vogel
26 Apr	Robert Cramer	Dartmouth	Aspergillus fumigatus biofilm mediated disease progression and drug resistance	Tamara Doering
3 May	Bree Aldridge	Tufts	Canceled	Christina Stallings
3 May	Christina Stallings	WashU	Inflammation as a Driver of Mycobacterium tuberculosis pathogenesis

Fall 2021

Sep 28	Kit Pogliano	UCSD	How to build an endospore and accelerate antibiotic drug discovery	Scott Hultgren
Oct 05	Nancy Keller	University of Wisconsin	Aspergillus fumigatus exometabolites mediating Multi-Kingdom interactions at the microbe and host interface	Jeff Henderson & Mary Dinauer
Oct 12	Harris Wang	Columbia University	Mapping & Modifying the Gut Microbiome in New Dimensions	Tae Seok Moon
Oct 19	Haina Shin	Washington University in St. Louis	Innate immune control of disease outcomes during mucosal viral infection	Sebla Kutluay & Tamara Doering
Oct 26	Benhur Lee	Icahn School of medicine at Mount Sinai	Interferon-silent Sendai virus mediated CRISPR-Cas9 editing in human cells	Carolina Lopez
Nov 02	Jeff Dvorin	Harvard University, Boston Children’s	One ring to rule them all — discovering novel cell biology in malaria parasite	Dan Goldberg
Nov 09	Ferric Fang	University of Washington	Pathogenesis of Enteric Fever	Mary Dinauer & Jeff Henderson
Nov 16	Alexander Ploss	Princeton University	Looking under the hood of a killer virus: new insights into the molecular biology of hepatitis B virus	Liang Shan
Nov 23	Margaret A. Scull	University of Maryland	At the Interface: Influenza Virus – Mucin Interactions in the Airway	Gaya Amarasinghe
Nov 30	David Rosen	Washington University in St. Louis	Klebsiella pneumoniae: Formidable Foe Necessitating a Multipronged Approach
Dec 07	Rob Knight	UC San Diego	Scaling microbiome analyses to millions of samples	Olivia Gorushi, Student

Spring 2021

Jan 12	Nir Drayman	The University of Chicago	Single Cell Virology (and drug repurposing efforts against SARS-CoV-2)	Carolina Lopez
Jan 19	Mary Estes	Baylor College of Medicine	Translating Stem Cell Biology to Understand Human Gastrointestinal Infections	Siyuan Ding
Jan 26	Anna Kuchina	University of Washington	Exploring microbial phenotypic diversity with single-cell RNA sequencing	Christina Stallings
Feb 02	Jacob Yount	Ohio State University	Beneficial and detrimental effects of type I interferons in virus infections	Carolina Lopez
Feb 09	Kevin Forsberg	Fred Hutchinson Cancer Research Center	The Hidden World of CRISPR-Cas Inhibitors	Michael Caparon
Feb 16	Thierry Diagana	Novartis	Discovery and advancement of new drugs for malaria and neglected tropical diseases	David Sibley
Feb 23	Filipa Rijo-Ferreira	UT Southwestern	Circadian rhythms in parasitic diseases: an underlying clock of malaria parasites	David Sibley
Mar 02	Natacha Ruiz	Ohio State University	Priority shipping: sending building blocks to the outer membrane	Michael Caparon
Mar 09	Eleftherios “Lefteris” Michailidis	The Rockefeller University	Modeling chronic hepatitis B infections in hepatocyte systems	Carolina Lopez
Mar 16	Boyuan Wang	MIT	Regulation of Metabolism and Viability of Bacteria by the Nucleotides (p)ppGpp and (p)ppApp	Christina Stallings
Mar 23	Matthew Chapman	University of Michigan	Polymerizing the Fiber Between Functional Amyloids and Pathogenic Neurodegenerative Disease	Scott Hultgren
Mar 30	Jason McClellan			Sean Whelan
Apr 06	Philip Kranzusch	Harvard Medical School	cGAS-like enzymes in immunity and host-microbe signaling	Sean Whelan
Apr 13	James Collins	UT Southwestern	Sex, drugs, and worms: developing a better understanding of schistosome biology to advance new therapies	Christina Stallings
Apr 20	Tobi Spielmann	Bernhard Nocht Institute for Tropical Medicine, Hamburg	Influence of nutrient access on drug action and resistance in malaria parasites	Dan Goldberg
Apr 27	Clare Smith	Duke University	A host-pathogen genetic map of tuberculosis susceptibility	Shabaana Khader
May 04	John Whitney	McMaster University	Molecular Basis for Chaperone Assisted Loading of Antibacterial Toxins onto a Bacterial Nanomachine	Mario Feldman

Fall 2020

Sept 22	Nicolas Manel	Institute Curie	Activation of innate immune sensors by viruses and self	Sebla Kutluay
Sept 29	Terry Dermody	University of Pittsburgh	A protein-folding network required for reovirus capsid assembly	Megan Baldridge
Oct 06	Anita Sil	University of California, San Francisco	Control of virulence and cell shape by temperature in Histoplasma capsulatum	Tamara Doering
Oct 13	Bill Powderly	Washington University	SARS CoV infection – learning from epidemiology	David Wang
Oct 20	Carey-Ann Burnham	Washington University	2020: A diagnostic testing odyssey	Tamara Doering
Oct 27	Mike Diamond	Washington University	Developing countermeasures to emerging RNA viruses: Stopping viruses at the point of attack	Joseph Vogel
Nov 03	Rachel Presti & Jane O’Halloran	Washington University	Update on clinical research on COVID-19	David Wang
Nov 10	Siyuan Ding	Washington University	SARS-CoV-2 in the gut: a fluid and crappy situation	Joseph Vogel
Nov 17	Ali Ellebedy	Washington University	B cell and antibody responses to respiratory viral infections	Tamara Doering
Dec 01	Kim Davis	Johns Hopkins	Keeping the stress to a minimum: cooperation between subpopulations of Yersinia pseudotuberculosis during infection	Joseph Vogel

Spring 2020

14-Jan	Floyd Wormley	University of Texas, San Antonio	Induction of Protective Immunity Against Pulmonary Cryptococcosis	Liza Miller, Student
21-Jan	James Cassat	Vanderbilt	Bone appetit: Host-pathogen interactions during osteomyelitis	Julie Wardenburg
28-Jan	Beth McCormick	University of Massachusetts	The ABC’s of Microbial Regulation of Lipid Immuno-modulators in Interested Health and Disease	Phil Tarr
4-Feb	Sarah Stanley	University of California, Berkeley	Metabolic regulation of M. tuberculosis infection	Stallings & J Philips
11-Feb	Keith Gull	Oxford University, UK	What has the Genome ever done for us? Understanding Kinetoplastid parasite structure, function and pathogenicity	Steve Beverley
18-Feb	Felipe Cava	Umea University	D-amino acids shape the environmental microbial diversity	Mario Feldman
25-Feb	Christina Cuomo	Broad Institute	Genomic epidemiology and evolution of Candida auris, a multidrug-resistant emerging fungal pathogen	Tamara Doering
3-Mar	David Tobin	Duke	Canceled	Christina Stallings
10-Mar	John Boothroyd	Stanford Medical School	Canceled	Steve Beverley
17-Mar	Peggy Cotter	University of North Carolina	Canceled	Joe Vogel
24-Mar	Ferric Fang	University of Washington	Canceled	Mary Dinauer
31-Mar	Sean Whelan	Washington University	Minus-Strand RNA Virus Polymerases – How Small Cofactors Regulate Large Multifunctional Proteins	Tamara Doering
7-Apr	Elina Zuniga	University of California, San Diego	Canceled	Shabaana Khader
14-Apr	Beatriz Fontoura	University of Texas Southwestern Medical Center	Canceled	Jacco Boon
21-Apr	Nancy Keller	University of Wisconsin, Madison	Canceled	Jeff Henderson
28-Apr	Rita Tamayo	University of North Carolina	Canceled	Mario Feldman
5-May	Judy Berman	Tel Aviv University	Canceled	Tamara Doering

Fall 2019

Sept 24	Juan Martinez	Louisiana State University	Spotted Fever Group Rickettsia-host cell interactions: a tale of the Trojan Horse.	Scott Hultgren
Oct 1	Mario Feldman	Washington University	Selfish MDR plasmids take control of gene regulation and pathogenesis in Acinetobacter baumannii	Shabaana Khader
Oct 8	Juan Alfonzo	Ohio State	Dynamic interplay between tRNA transport and processing: On the possibility of tunable modifications	Dan Goldberg
Oct 15	Dan Portnoy	University of California, Berkeley	How intracellular pathogens sense the host cell and vice versa and the serendipitous discovery that Listeria monocytogenes is electrogenic	Joe Vogel
Oct 22	Rachel Dutton	University of California, San Diego	Dissecting microbiomes using cheese	Greg Harrison, Student
Oct 29	Igor Almeida	University of Texas, El Paso	alpha-Gal glycotopes as effective chemotherapy biomarkers and glycovaccines for Chagas disease and leishmaniasis	Steve Beverley
Nov 05	Sam Behar	University of Massachusetts	Recognizing the Problem: T cell recognition of Mycobacterium tuberculosis infected macrophages	Shabaana Khader
Nov 12	Barbara Rehermann	National Institutes of Health	Natural versus laboratory world: Wild mouse microbiota improve host fitness and preclinical models	Dave Wang
Nov 19	Adam Burgener	University of Manitoba	The microbiome in mucosal immunity and HIV Transmission	Amanda Lewis
Nov 26	Victoria D’Souza	Harvard	Structures of the HIV genome: Insights into regulation of reverse transcription, transcription and translation	Jacco Boon
Dec 03	David Underhill	Cedars-Sinai Medical Center	A Role for Commensal Fungi in Inflammatory Bowel Disease?	Jenny Lodge
Dec 10	Florian Krammer	Mount Sinai School of Medicine	Antibody responses to conserved epitopes on the influenza virus glycoproteins	Ali Ellebedy

Spring 2019

Jan 29	Julie Overbaugh	Fred Hutchinson Cancer Research Center	The potential of international collaborations for HIV prevention: Studies of mother-infant transmission	Michael Diamond
Feb 05	Carla Saleh	Pasteur Institute	Small RNAs and antiviral defense in insects	David Wang
Feb 12	Andrew Gewirtz	Georgia State University	Gut microbiota, diet, chronic inflammation, and metabolic syndrome	Phil Tarr
Feb 19	Peter Greenberg	University of Washington	Communication, Cooperation and Conflict in the Microbial World: Targets for Therapeutic Development?	Omar Delannoy-Bruno, Student
Feb 26	Galit Alter	Ragon Institute of MGH, MIT, and Harvard	The role of antibodies in TB infection	Christina Stallings
Mar 05	Samuel Behar	University of Massachusetts	Canceled	Shabaana Khader
Mar 12	Deborah Lenschow	Washington University	Chikungunya virus arthritis: New ingiths into pathogenesis and treatment	David Wang
Mar 19	Alan Aderem	Center for Infectious Disease Research	Canceled	Jen Philips & Scott Hultgren
Mar 26	Scott Gray-Owen	University of Toronto	Playing with fire: The fine line between immunity and immunopathogenesis	Jim Fleckenstein
Apr 02	Darren Higgins	Harvard Medical School	From gastroenteritis to meningoencephalitis: How Listeria monocytogenescrosses the blood-brain barrier to infect the brain	Mario Feldman & Shabaana Khader
Apr 09	Amariliz Rivera	Rutgers- New Jersey Medical School	Type III interferon is a critical regulator of innate antifungal immunity	Christina Stallings
Apr 16	Wei-Shau Hu	National Institutes of Health	How does HIV-1 transfer its genetic information to progeny?	Sebla Kutluay
Apr 23	Igor Brodsky	University of Pennsylvania	Apoptotic and non-apoptotic functions of cell death pathways in anti-microbial host defense	Christina Stallings
Apr 30	Jörn Coers	Duke University	Interferon-inducible GTPases in host defense and inflammation	Jen Philips
May 07	Lori Burrows	McMaster University	Old drugs, new tricks – using bacterial biofilms to reveal cryptic antibiotic activity	Mario Feldman

Fall 2018

Sept 18	Jo Handelsman	University of Wisconsin, Madison	Drosophila microbiome influences fly behavior	Lisa Drewy
Sept 25	Margaret A. Phillips	University of Texas Southwestern Medical Center	Metabolic enzymes as drug targets in parasitic protozoa	Daniel Goldberg
Oct 02	Emmie De Wit	Rocky Mountain Lab National Institutes of Health/NIAID	Pathogenesis of Nipah virus and other emerging respiratory viruses	Jacco Boon
Oct 09	Hiten Madhani	University of California, San Francisco	Epigenetic memory over geological timescales	Tamara Doering
Oct 16	Miriam Braunstein	University of North Carolina, Chapel Hill	A novel protein export chaperone for a set of Mycobacterium tuberculosis virulence effectors	Joseph Vogel
Oct 23	Andy Fire	Stanford University	Opportunistic RNAs and acquisitive genomes	David Wang
Oct 30	Alejandro Aballay	Oregon Health Center University	Neural control of response against bacterial infections and immune homeostasis	Mario Feldman
Nov 06	Roy Curtiss III	University of Florida	Protective immunity enhanced Salmonella vaccine vector platforms	Michael Caparon
Nov 13	Julie Bubeck-Wardenburg	Washington University	Bacterial Toxins – Architects of long term health outcomes in the host?	Joseph Vogel
Nov 20	Michaela Gack	University of Chicago	Intracellular RNA- and TRIM protein-mediated antiviral defense mechanisms	Sebla Kutluay
Nov 27	Noam Cohen	University of Pennsylvania	The role of taste receptors in upper respiratory innate immunity	Andrew Kau
Dec 04	Renee Tsolis	University of California, Davis	ER stress: a pattern of pathogenesis during infection with intracellular bacteria	Joseph Vogel

Spring 2018

Jan 23	Nels Elde	University of Utah	Evolutionary innovations from biological collisions	David Wang
Jan 30	Michael Shiloh	University of Texas Southwestern	Close encounters of the microbial kind: How Mycobacterium tuberculosis traverses the mucosal barrier	Christina Stallings
Feb 06	Edward Miao	University of North Carolina	NK cells and CTLs clear intracellular bacteria via caspase-7	Brian Edelson
Feb 13	Lakshmi Rajagopol	University of Washington	Understanding group B Streptococcus infections	Amanda Lewis
Feb 20	Margaret Phillips	University of Texas Southwestern	Canceled	Dan Goldberg
Feb 27	Christina Stallings	Washington University	Surviving Mycobacterium tuberculosis infection from the perspective of the pathogen and the host	Steve Beverley
Mar 06	Christine Jacobs-Wagner	Yale University	What makes the Lyme disease bacterium tick?	Scott Hultgren
Mar 13	Victor Torres	New York University	Staphylococcus aureus leukocidins: from receptor identification to unraveling their role in pathogenesis	Caparon & Vogel
Mar 20	Sergio Grinstein	University of Toronto	Signaling phagocytosis: role of receptors, integrins and the cytoskeleton	Jennifer Philips
Mar 27	Eran Elivan	Weizmann Institute of Science	Host microbiome interactions in health and disease	Andrew Kau
Apr 03	Steve Higgs	Kansas State University	Virus-vector-vertebrate interactions	Gary Weil
Apr 10	Sunny Shin	University of Pennsylvania	Innate immune defense against intracellular bacterial pathogens	Joe Vogel
Apr 17	No Seminar
Apr 24	Xiaorong Lin	University of Georgia	Morphogenesis, sexual reproduction and cryptococcosis	Tamara Doering
May 01	Paul D. Bieniasz	Rockefeller University	Intrinsic host defense against retroviruses	Sebla Kutluay
May 08	Amanda Lewis	Washington University	A single member of the vaginal microbiota drives colonization and disease by diverse urogenital pathogens	Scott Hultgren

Fall 2017

Sept 19	Robert Abramovitch	Michigan State University	Small molecules that inhibit Mycobacterium tuberculosis environmental sensing and virulence	Christina Stallings
Sept 26	Jacco Boon	Washington University	RNA structures and packaging of Influenza virus genome	Sebla Kutluay
Oct 03	Chris Whitfield	University of Guelph	Assembly of microbial glycolipids	Mario Feldman
Oct 10	Joe Smith	Center for Infectious Disease Research	Dissecting cerebral malaria pathogenesis	Dan Goldberg
Oct 17	Joshua Blodgett	Washington University	Drugs from bugs: Harnessing actinomycete secondary metabolism to address therapeutic needs	Joe Vogel
Oct 24	Shabaana Khader	Washington University	Host immunity to tuberculosis: A balancing act	Dave Wang
Oct 31	Jonathan Miner	Washington University	Is Zika virus unique? Defining the capacity of multiple arboviruses to cause congenital disease	Dave Wang
Nov 07	Stuart Levitz	University of Massachusetts	Vaccine development against Cryptococcus: The baker delivers the antigens	Jennifer Lodge & Tamara Doering
Nov 14	Galit Alter	Ragon Institute of MGH, MIT and Harvard	Canceled	Christina Stallings
Nov 21	Ana Fernandez Sesma	Mount Sinai	Immune evasion mechanisms by dengue virus	Mike Diamond
Nov 28	Joanne Engel	University of California, San Francisco	Obligate intracellular pathogens are master cell biologists: Decoding the Chlamydia inclusion membrane interactome	Joe Vogel
Dec 05	Robert Davey	Texas Biomedical	Macropinocytosis seen through the eyes of Ebola virus	Gay Amarasinghe
Dec 12	Shelley Payne	University of Texas	Role of cardiolipin in the intracellular lifestyle of Shigella flexneri	Phil Tarr