2023
| Caparon, M., Xu, W., Bradstreet, T., Zou, Z., Hickerson, S., Zhou, Y., He, H., & Edelson, B. (2023). Reprogramming Short-Chain Fatty Acid Metabolism Mitigates Tissue Damage for Streptococcus pyogenes Necrotizing Skin Infection. Research square, rs.3.rs-3689163. https://doi.org/10.21203/rs.3.rs-3689163/v1 |
| Adams, L. J., VanBlargan, L. A., Liu, Z., Gilchuk, P., Zhao, H., Chen, R. E., Raju, S., Chong, Z., Whitener, B. M., Shrihari, S., Jethva, P. N., Gross, M. L., Crowe, J. E., Jr, Whelan, S. P. J., Diamond, M. S., & Fremont, D. H. (2023). A broadly reactive antibody targeting the N-terminal domain of SARS-CoV-2 spike confers Fc-mediated protection. Cell reports. Medicine, 4(12), 101305. https://doi.org/10.1016/j.xcrm.2023.101305 |
| Achouri, E., Felt, S. A., Hackbart, M., Rivera-Espinal, N. S., & López, C. B. (2023). VODKA2: a fast and accurate method to detect non-standard viral genomes from large RNA-seq data sets. RNA (New York, N.Y.), 30(1), 16–25. https://doi.org/10.1261/rna.079747.123 |
| Heeren, S., Maes, I., Sanders, M., Lye, L. F., Adaui, V., Arevalo, J., Llanos-Cuentas, A., Garcia, L., Lemey, P., Beverley, S. M., Cotton, J. A., Dujardin, J. C., & Van den Broeck, F. (2023). Diversity and dissemination of viruses in pathogenic protozoa. Nature communications, 14(1), 8343. https://doi.org/10.1038/s41467-023-44085-2 |
| Souza, C. E., Jacobson, N. E., An, M. A., Droit, L., Vega, A. A., Rosales, M., Mihindukulasuriya, K. A., Pastrana, K., Handley, S. A., Parkes, M., Rimmer, J., Wang, D., Dinsdale, E. A., A Edwards, R., & Segall, A. M. (2024). Draft genomes of 12 Bifidobacterium isolates from human IBD fecal samples. Microbiology resource announcements, 13(1), e0013023. https://doi.org/10.1128/mra.00130-23 |
| Castro, Í. A., Yang, Y., Gnazzo, V., Kim, D. H., Van Dyken, S. J., & López, C. B. (2023). Murine Parainfluenza Virus Persists in Lung Innate Immune Cells Sustaining Chronic Lung Pathology. bioRxiv : the preprint server for biology, 2023.11.07.566103. https://doi.org/10.1101/2023.11.07.566103 |
| González Aparicio, L. J., Yang, Y., Hackbart, M., & López, C. B. (2023). Copy-back viral genomes induce a cellular stress response that interferes with viral protein expression without affecting antiviral immunity. PLoS biology, 21(11), e3002381. https://doi.org/10.1371/journal.pbio.3002381 |
| Berida, T., McKee, S. R., Chatterjee, S., Manning, D. L., Li, W., Pandey, P., Tripathi, S. K., Mreyoud, Y., Smirnov, A., Doerksen, R. J., Jackson, M., Ducho, C., Stallings, C. L., & Roy, S. (2023). Discovery, Synthesis, and Optimization of 1,2,4-Triazolyl Pyridines Targeting Mycobacterium tuberculosis. ACS infectious diseases, 9(11), 2282–2298. https://doi.org/10.1021/acsinfecdis.3c00341 |
| Hackbart, M., & López, C. B. (2023). S RNA Intergenic Deletions Drive Viral Interference during Arenavirus Infections. bioRxiv : the preprint server for biology, 2023.10.31.564889. https://doi.org/10.1101/2023.10.31.564889 |
| McGuffey, J. C., Jackson-Litteken, C. D., Di Venanzio, G., Zimmer, A. A., Lewis, J. M., Distel, J. S., Kim, K. Q., Zaher, H. S., Alfonzo, J., Scott, N. E., & Feldman, M. F. (2023). The tRNA methyltransferase TrmB is critical for Acinetobacter baumannii stress responses and pulmonary infection. mBio, 14(5), e0141623. https://doi.org/10.1128/mbio.01416-23 |
| McAllaster, M. R., Bhushan, J., Balce, D. R., Orvedahl, A., Park, A., Hwang, S., Sullender, M. E., Sibley, L. D., & Virgin, H. W. (2023). Autophagy gene-dependent intracellular immunity triggered by interferon-γ. mBio, 14(6), e0233223. Advance online publication. https://doi.org/10.1128/mbio.02332-23 |
| Agustinho, D. P., Brown, H. L., Chen, G., Gaylord, E. A., Geddes-McAlister, J., Brent, M. R., & Doering, T. L. (2023). Unbiased discovery of natural sequence variants that influence fungal virulence. Cell host & microbe, 31(11), 1910–1920.e5. https://doi.org/10.1016/j.chom.2023.10.002 |
| Serafim, T. D., Iniguez, E., Barletta, A. B. F., Cecilio, P., Doehl, J. S. P., Short, M., Lack, J., Nair, V., Disotuar, M., Wilson, T., Coutinho-Abreu, I. V., Meneses, C., Andersen, J., Alves E Silva, T. L., Oliveira, F., Vega-Rodriguez, J., Barillas-Mury, C., Ribeiro, J. M. C., Beverley, S. M., Kamhawi, S., … Valenzuela, J. G. (2023). Leishmania genetic exchange is mediated by IgM natural antibodies. Nature, 623(7985), 149–156. https://doi.org/10.1038/s41586-023-06655-8 |
| Rosen, A. L., Lint, M. A., Voelker, D. H., Gilbert, N. M., Tomera, C. P., Santiago-Borges, J., Wallace, M. A., Hannan, T. J., Burnham, C. D., Hultgren, S. J., & Kau, A. L. (2023). Secretory Leukocyte Protease Inhibitor Protects Against Severe Urinary Tract Infection in Mice. bioRxiv : the preprint server for biology, 2023.10.10.561753. https://doi.org/10.1101/2023.10.10.561753 |
| Ihedioha, O. C., Sivakoses, A., Beverley, S. M., McMahon-Pratt, D., & Bothwell, A. L. M. (2023). Leishmania major-derived lipophosphoglycan influences the host’s early immune response by inducing platelet activation and DKK1 production via TLR1/2. Frontiers in immunology, 14, 1257046. https://doi.org/10.3389/fimmu.2023.1257046 |
| Naik, S. K., McNehlan, M. E., Mreyoud, Y., Kinsella, R. L., Smirnov, A., Chowdhury, C. S., McKee, S. R., Dubey, N., Woodson, R., Kreamalmeyer, D., & Stallings, C. L. (2023). Type I IFN signaling in the absence of IRGM1 promotes M. tuberculosis replication in immune cells by suppressing T cell responses. bioRxiv : the preprint server for biology, 2023.10.03.560720. https://doi.org/10.1101/2023.10.03.560720 |
| Berna, A. Z., Merriman, J. A., Mellett, L., Parchment, D. K., Caparon, M. G., & Odom John, A. R. (2023). Volatile profiling distinguishes Streptococcus pyogenes from other respiratory streptococcal species. mSphere, 8(5), e0019423. https://doi.org/10.1128/msphere.00194-23 |
| Berna, A. Z., Merriman, J. A., Mellett, L., Parchment, D. K., Caparon, M. G., & Odom John, A. R. (2023). Volatile profiling distinguishes Streptococcus pyogenes from other respiratory streptococcal species. mSphere, e0019423. Advance online publication. https://doi.org/10.1128/msphere.00194-23 |
| Berida, T., McKee, S. R., Chatterjee, S., Manning, D. L., Li, W., Pandey, P., Tripathi, S. K., Mreyoud, Y., Smirnov, A., Doerksen, R. J., Jackson, M., Ducho, C., Stallings, C. L., & Roy, S. (2023). Discovery, Synthesis, and Optimization of 1,2,4-Triazolyl Pyridines Targeting Mycobacterium tuberculosis. ACS infectious diseases, 10.1021/acsinfecdis.3c00341. Advance online publication. https://doi.org/10.1021/acsinfecdis.3c00341 |
| Walker, J. N., Hanson, B. M., Hunter, T., Simar, S. R., Duran Ramirez, J. M., Obernuefemann, C. L. P., Parikh, R. P., Tenenbaum, M. M., Margenthaler, J. A., Hultgren, S. J., & Myckatyn, T. M. (2023). A prospective randomized clinical trial to assess antibiotic pocket irrigation on tissue expander breast reconstruction. Microbiology spectrum, e0143023. Advance online publication. https://doi.org/10.1128/spectrum.01430-23 |
| Flores-Mireles, A., Molina, J., Kohler, K., Gager, C., Andersen, M., Wongso, E., Lucas, E., Paik, A., Xu, W., Donahue, D., Bergeron, K., Klim, A., Caparon, M., Hultgren, S ., Desai, A., Ploplis, V., Flick, M., & Castellino, F. J. (2023). Fibrinolytic-deficiencies predispose hosts to septicemia from a catheter-associated UTI. Research square, rs.3.rs-3263501. https://doi.org/10.21203/rs.3.rs-3263501/v1 |
| Choy, H. L., Gaylord, E. A., & Doering, T. L.(2023). Ergosterol distribution controls surface structure formation and fungal pathogenicity. mBio, 14(4), e0135323. https://doi.org/10.1128/mbio.01353-23 |
| McGuffey, J. C., Jackson-Litteken, C. D., Di Venanzio, G., Zimmer, A. A., Lewis, J. M., Distel, J. S., Kim, K. Q., Zaher, H. S., Alfonzo, J., Scott, N. E., & Feldman, M. F. (2023). The tRNA methyltransferase TrmB is critical for Acinetobacter baumannii stress responses and pulmonary infection. mBio, e0141623. Advance online publication. https://doi.org/10.1128/mbio.01416-23 |
| Paudel, S., Guedry, S., Obernuefemann, C. L. P., Hultgren, S. J., Walker, J. N., & Kulkarni, R. (2023). Defining the Roles of Pyruvate Oxidation, TCA Cycle, and Mannitol Metabolism in Methicillin-Resistant Staphylococcus aureus Catheter-Associated Urinary Tract Infection. Microbiology spectrum, 11(4), e0536522. https://doi.org/10.1128/spectrum.05365-22 |
| Shema Mugisha, C., Dinh, T., Kumar, A., Tenneti, K., Eschbach, J. E., Davis, K., Gifford, R., Kvaratskhelia, M., & Kutluay, S. B. (2022). Emergence of Compensatory Mutations Reveals the Importance of Electrostatic Interactions between HIV-1 Integrase and Genomic RNA. mBio, 13(5), e0043122. https://doi.org/10.1128/mbio.00431-22 |
| Sarkar, S., Mayer Bridwell, A. E., Good, J. A. D., Wang, E. R., McKee, S. R., Valenta, J., Harrison, G. A., Flentie, K. N., Henry, F. L., Wixe, T., Demirel, P., Vagolu, S. K., Chatagnon, J., Machelart, A., Brodin, P., Tønjum, T., Stallings, C. L., & Almqvist, F. (2023). Design, Synthesis, and Evaluation of Novel Δ2-Thiazolino 2-Pyridone Derivatives That Potentiate Isoniazid Activity in an Isoniazid-Resistant Mycobacterium tuberculosis Mutant. Journal of medicinal chemistry, 66(16), 11056–11077. https://doi.org/10.1021/acs.jmedchem.3c00358 |
| Brunetti NS, Davanzo GG, de Moraes D, Ferrari AJR, Souza GF, Muraro SP, Knittel TL, Boldrini VO, Monteiro LB, Virgílio-da-Silva JV, Profeta GS, Wassano NS, Nunes Santos L, Carregari VC, Dias AHS, Veras FP, Tavares LA, Forato J, Castro IMS, Silva-Costa LC, Palma AC, Mansour E, Ulaf RG, Bernardes AF, Nunes TA, Ribeiro LC, Agrela MV, Moretti ML, Buscaratti LI, Crunfli F, Ludwig RG, Gerhardt JA, Munhoz-Alves N, Marques AM, Sesti-Costa R, Amorim MR, Toledo-Teixeira DA, Parise PL, Martini MC, Bispos-Dos-Santos K, Simeoni CL, Granja F, Silvestrini VC, de Oliveira EB, Faca VM, Carvalho M, Castelucci BG, Pereira AB, Coimbra LD, Dias MMG, Rodrigues PB, Gomes ABSP, Pereira FB, Santos LMB, Bloyet LM, Stumpf S, Pontelli MC, Whelan S , Sposito AC, Carvalho RF, Vieira AS, Vinolo MAR, Damasio A, Velloso L, Figueira ACM, da Silva LLP, Cunha TM, Nakaya HI, Marques-Souza H, Marques RE, Martins-de-Souza D, Skaf MS, Proenca-Modena JL, Moraes-Vieira PMM, Mori MA, Farias AS. SARS-CoV-2 uses CD4 to infect T helper lymphocytes. Elife. 2023 Jul 31;12:e84790. doi: 10.7554/eLife.84790. PMID: 37523305; PMCID: PMC10390044. |
| Funkhouser-Jones, L. J., Xu, R., Wilke, G., Fu, Y., Schriefer, L. A., Makimaa, H., Rodgers, R., Kennedy, E. A., VanDussen, K. L., Stappenbeck, T. S., Baldridge, M. T., & Sibley, L. D. (2023). Microbiota-produced indole metabolites disrupt mitochondrial function and inhibit Cryptosporidium parvum growth. Cell reports, 42(7), 112680. https://doi.org/10.1016/j.celrep.2023.112680 |
| Sartorio, M. G., Pardue, E. J., Scott, N. E., & Feldman, M. F. (2023). Human gut bacteria tailor extracellular vesicle cargo for the breakdown of diet- and host-derived glycans. Proceedings of the National Academy of Sciences of the United States of America, 120(27), e2306314120. https://doi.org/10.1073/pnas.2306314120 |
| Bisaro, F., Shuman, H. A., Feldman, M. F., Gebhardt, M. J., & Pukatzki, S. (2023). Acinetobacter baumannii ATCC 17978 encodes a microcin system with antimicrobial properties for contact-independent competition. Microbiology (Reading, England), 169(6), 001346. https://doi.org/10.1099/mic.0.001346 |
| Merriman, J. A., Xu, W., & Caparon, M. G.(2023). Central carbon flux controls growth/damage balance for Streptococcus pyogenes. PLoS pathogens, 19(6), e1011481. https://doi.org/10.1371/journal.ppat.1011481 |
| Kinsella, R. L., Kimmey, J. M., Smirnov, A., Woodson, R., Gaggioli, M. R., Chavez, S. M., Kreamalmeyer, D., & Stallings, C. L. (2023). Autophagy prevents early proinflammatory responses and neutrophil recruitment during Mycobacterium tuberculosis infection without affecting pathogen burden in macrophages. PLoS biology, 21(6), e3002159. https://doi.org/10.1371/journal.pbio.3002159 |
| Distel, J. S., Di Venanzio, G., Mackel, J. J., Rosen, D. A., & Feldman, M. F.(2023). Replicative Acinetobacter baumannii strains interfere with phagosomal maturation by modulating the vacuolar pH. PLoS pathogens, 19(6), e1011173. https://doi.org/10.1371/journal.ppat.1011173 |
| Li, Y., Majumdar, S., Treen, R., Sharma, M. R., Corro, J., Gamper, H. B., Manjari, S. R., Prusa, J., Banavali, N. K., Stallings, C. L., Hou, Y. M., Agrawal, R. K., & Ojha, A. K. (2023). Starvation sensing by mycobacterial RelA/SpoT homologue through constitutive surveillance of translation. Proceedings of the National Academy of Sciences of the United States of America, 120(22), e2302006120. https://doi.org/10.1073/pnas.2302006120 |
| Popli, P., Tang, S., Chadchan, S. B., Talwar, C., Rucker, E. B., 3rd, Guan, X., Monsivais, D., Lydon, J. P., Stallings, C. L., Moley, K. H., & Kommagani, R. (2023). Beclin-1-dependent autophagy, but not apoptosis, is critical for stem-cell-mediated endometrial programming and the establishment of pregnancy. Developmental cell, 58(10), 885–897.e4. https://doi.org/10.1016/j.devcel.2023.03.013 |
| Jiang, H., Joshi, A., Gan, T., Janowski, A. B., Fujii, C., Bricker, T. L., Darling, T. L., Harastani, H. H., Seehra, K., Chen, H., Tahan, S., Jung, A., Febles, B., Blatter, J. A., Handley, S. A., Parikh, B. A., Wang, D., & Boon, A. C. M. (2023). The Highly Conserved Stem-Loop II Motif Is Dispensable for SARS-CoV-2. Journal of virology, 97(6), e0063523. https://doi.org/10.1128/jvi.00635-23 |
| Whitworth, I. T., Knoener, R. A., Puray-Chavez, M., Halfmann, P., Romero, S., Baddouh, M., Scalf, M., Kawaoka, Y., Kutluay, S. B., Smith, L. M., & Sherer, N. M. (2023). Defining distinct RNA-protein interactomes of SARS-CoV-2 genomic and subgenomic RNAs. bioRxiv : the preprint server for biology, 2023.05.15.540806. https://doi.org/10.1101/2023.05.15.540806 |
| Alsoussi WB, Malladi SK, Zhou JQ, Liu Z, Ying B, Kim W, Schmitz AJ, Lei T, Horvath SC, Sturtz AJ, McIntire KM, Evavold B, Han F, Scheaffer SM, Fox IF, Mirza SF, Parra-Rodriguez L, Nachbagauer R, Nestorova B, Chalkias S, Farnsworth CW, Klebert MK, Pusic I, Strnad BS, Middleton WD, Teefey SA, Whelan SPJ, Diamond MS, Paris R, O’Halloran JA, Presti RM, Turner JS, Ellebedy AH. SARS-CoV-2 Omicron boosting induces de novo B cell response in humans. Nature. 2023 May;617(7961):592-598. doi: 10.1038/s41586-023-06025-4. Epub 2023 Apr 3. PMID: 37011668. |
| Blaine, H. C., Simmons, L. A., & Stallings, C. L.(2023). Diverse Mechanisms of Helicase Loading during DNA Replication Initiation in Bacteria. Journal of bacteriology, 205(4), e0048722. https://doi.org/10.1128/jb.00487-22 |
| Haram, C. S., Moitra, S., Keane, R., Kuhlmann, F. M., Frankfater, C., Hsu, F. F., Beverley, S. M., Zhang, K., & Keyel, P. A. (2023). The sphingolipids ceramide and inositol phosphorylceramide protect the Leishmania major membrane from sterol-specific toxins. The Journal of biological chemistry, 299(6), 104745. https://doi.org/10.1016/j.jbc.2023.104745 |
| Jung, J., Kang, Y. S., Brown, H., Mateusiak, C., Doering, T. L., & Brent, M. R. (2023). How host-like signals drive gene expression and gene expression drives capsule expansion in Cryptococcus neoformans. bioRxiv : the preprint server for biology, 2023.04.19.537239. https://doi.org/10.1101/2023.04.19.537239 |
| Wang, Y. T., Sansone, A., Smirnov, A., Stallings, C. L., & Orvedahl, A. (2023). Myeloid autophagy genes protect mice against fatal TNF- and LPS-induced cytokine storm syndromes. Autophagy, 19(4), 1114–1127. https://doi.org/10.1080/15548627.2022.2116675 |
| Saraav, I., & Sibley, L. D.(2023). Dendritic Cells and Cryptosporidium: From Recognition to Restriction. Microorganisms, 11(4), 1056. https://doi.org/10.3390/microorganisms11041056 |
| Cable, J., Sun, J., Cheon, I. S., Vaughan, A. E., Castro, I. A., Stein, S. R., López, C. B., Gostic, K. M., Openshaw, P. J. M., Ellebedy, A. H., Wack, A., Hutchinson, E., Thomas, M. M., Langlois, R. A., Lingwood, D., Baker, S. F., Folkins, M., Foxman, E. F., Ward, A. B., Schwemmle, M., … Eddens, T. (2023). Respiratory viruses: New frontiers-a Keystone Symposia report. Annals of the New York Academy of Sciences, 1522(1), 60–73. https://doi.org/10.1111/nyas.14958 |
| Russell, S. K., Harrison, J. K., Olson, B. S., Lee, H. J., O’Brien, V. P., Xing, X., Livny, J., Yu, L., Roberson, E. D. O., Bomjan, R., Fan, C., Sha, M., Estfanous, S., Amer, A. O., Colonna, M., Stappenbeck, T. S., Wang, T., Hannan, T. J., & Hultgren, S. J.(2023). Uropathogenic Escherichia coli infection-induced epithelial trained immunity impacts urinary tract disease outcome. Nature microbiology, 8(5), 875–888. https://doi.org/10.1038/s41564-023-01346-6 |
| Dong, W., Wang, J., Tian, L., Zhang, J., Settles, E. W., Qin, C., Steinken-Kollath, D. R., Itogawa, A. N., Celona, K. R., Yi, J., Bryant, M., Mead, H., Jaramillo, S. A., Lu, H., Li, A., Zumwalt, R. E., Dadwal, S., Feng, P., Yuan, W., Whelan, S. P.J., … Yu, J. (2023). Factor Xa cleaves SARS-CoV-2 spike protein to block viral entry and infection. Nature communications, 14(1), 1936. https://doi.org/10.1038/s41467-023-37336-9 |
| Cubillas, C., Sandoval Del Prado, L. E., Goldacker, S., Fujii, C., Pinski, A. N., Zielke, J., & Wang, D.(2023). The alg-1 Gene Is Necessary for Orsay Virus Replication in Caenorhabditis elegans. Journal of virology, 97(4), e0006523. https://doi.org/10.1128/jvi.00065-23 |
| Peelaerts, W., Mercado, G., George, S., Villumsen, M., Kasen, A., Aguileta, M., Linstow, C., Sutter, A. B., Kuhn, E., Stetzik, L., Sheridan, R., Bergkvist, L., Meyerdirk, L., Lindqvist, A., Gavis, M. L. E., Van den Haute, C., Hultgren, S. J., Baekelandt, V., Pospisilik, J. A., Brudek, T., … Brundin, P. (2023). Urinary tract infections trigger synucleinopathy via the innate immune response. Acta neuropathologica, 145(5), 541–559. https://doi.org/10.1007/s00401-023-02562-4 |
| Heeren, S., Maes, I., Sanders, M., Lye, L. F., Arevalo, J., Llanos-Cuentas, A., Garcia, L., Lemey, P., Beverley, S. M., Cotton, J. A., Dujardin, J. C., & Van den Broeck, F. (2023). Parasite hybridization promotes spreading of endosymbiotic viruses. bioRxiv : the preprint server for biology, 2023.03.24.534103. https://doi.org/10.1101/2023.03.24.534103 |
| Frankfater, C. F., Sartorio, M. G., Valguarnera, E., Feldman, M. F., & Hsu, F. F. (2023). Lipidome of the Bacteroides Genus Containing New Peptidolipid and Sphingolipid Families Revealed by Multiple-Stage Mass Spectrometry. Biochemistry, 62(6), 1160–1180. https://doi.org/10.1021/acs.biochem.2c00664 |
| Zhu, M., Lv, J., Wang, W., Guo, R., Zhong, C., Antia, A., Zeng, Q., Li, J., Liu, Q., Zhou, J., Zhu, X., Fan, B., Ding, S., & Li, B. (2023). CMPK2 is a host restriction factor that inhibits infection of multiple coronaviruses in a cell-intrinsic manner. PLoS biology, 21(3), e3002039. https://doi.org/10.1371/journal.pbio.3002039 |
| Kawagishi, T., Sánchez-Tacuba, L., Feng, N., Costantini, V. P., Tan, M., Jiang, X., Green, K. Y., Vinjé, J., Ding, S., & Greenberg, H. B. (2023). Mucosal and systemic neutralizing antibodies to norovirus induced in infant mice orally inoculated with recombinant rotaviruses. Proceedings of the National Academy of Sciences of the United States of America, 120(9), e2214421120. https://doi.org/10.1073/pnas.2214421120 |
| Goodrum F, Lowen AC, Lakdawala S, Alwine J, Casadevall A, Imperiale MJ, Atwood W, Avgousti D, Baines J, Banfield B, Banks L, Bhaduri-McIntosh S, Bhattacharya D, Blanco-Melo D, Bloom D, Boon A, Boulant S, Brandt C, Broadbent A, Brooke C, Cameron C, Campos S, Caposio P, Chan G, Cliffe A, Coffin J, Collins K, Damania B, Daugherty M, Debbink K, DeCaprio J, Dermody T, Dikeakos J, DiMaio D, Dinglasan R, Duprex WP, Dutch R, Elde N, Emerman M, Enquist L, Fane B, Fernandez-Sesma A, Flenniken M, Frappier L, Frieman M, Frueh K, Gack M, Gaglia M, Gallagher T, Galloway D, García-Sastre A, Geballe A, Glaunsinger B, Goff S, Greninger A, Hancock M, Harris E, Heaton N, Heise M, Heldwein E, Hogue B, Horner S, Hutchinson E, Hyser J, Jackson W, Kalejta R, Kamil J, Karst S, Kirchhoff F, Knipe D, Kowalik T, Lagunoff M, Laimins L, Langlois R, Lauring A, Lee B, Leib D, Liu SL, Longnecker R, Lopez C, Luftig M, Lund J, Manicassamy B, McFadden G, McIntosh M, Mehle A, Miller WA, Mohr I, Moody C, Moorman N, Moscona A, Mounce B, Munger J, Münger K, Murphy E, Naghavi M, Nelson J, Neufeldt C, Nikolich J, O’Connor C, Ono A, Orenstein W, Ornelles D, Ou JH, Parker J, Parrish C, Pekosz A, Pellett P, Pfeiffer J, Plemper R, Polyak S, Purdy J, Pyeon D, Quinones-Mateu M, Renne R, Rice C, Schoggins J, Roller R, Russell C, Sandri-Goldin R, Sapp M, Schang L, Schmid S, Schultz-Cherry S, Semler B, Shenk T, Silvestri G, Simon V, Smith G, Smith J, Spindler K, Stanifer M, Subbarao K, Sundquist W, Suthar M, Sutton T, Tai A, Tarakanova V, tenOever B, Tibbetts S, Tompkins S, Toth Z, van Doorslaer K, Vignuzzi M, Wallace N, Walsh D, Weekes M, Weinberg J, Weitzman M, Weller S, Whelan S, White E, Williams B, Wobus C, Wong S, Yurochko A. Virology under the Microscope-a Call for Rational Discourse. mBio. 2023 Feb 28;14(1):e0018823. doi: 10.1128/mbio.00188-23. Epub 2023 Jan 26. PMID: 36700642; PMCID: PMC9973315. |
| Wan, W., Dong, H., Lai, D. H., Yang, J., He, K., Tang, X., Liu, Q., Hide, G., Zhu, X. Q., Sibley, L. D., Lun, Z. R., & Long, S. (2023). The Toxoplasma micropore mediates endocytosis for selective nutrient salvage from host cell compartments. Nature communications, 14(1), 977. https://doi.org/10.1038/s41467-023-36571-4 |
| Choy, H. L., Gaylord, E. A., & Doering, T. L.(2023). Ergosterol distribution controls surface structure formation and fungal pathogenicity. bioRxiv : the preprint server for biology, 2023.02.17.528979. https://doi.org/10.1101/2023.02.17.528979 |
| Akey, M. E., Xu, R., Ravindran, S., Funkhouser-Jones, L., & Sibley, L. D.(2023). Apical Secretory Glycoprotein Complex Contributes to Cell Attachment and Entry by Cryptosporidium parvum. mBio, 14(1), e0306422. https://doi.org/10.1128/mbio.03064-22 |
| Santiago-Tirado, F. H., Hurtaux, T., Geddes-McAlister, J., Nguyen, D., Helms, V., Doering, T. L., & Römisch, K. (2023). The ER Protein Translocation Channel Subunit Sbh1 Controls Virulence of Cryptococcus neoformans. mBio, 14(1), e0338422. https://doi.org/10.1128/mbio.03384-22 |
| Harrison, G. A., Cho, K., Wang, E. R., Sarkar, S., Almqvist, F., Patti, G. J., & Stallings, C. L.(2023). Inducing vulnerability to InhA inhibition restores isoniazid susceptibility in drug resistant Mycobacterium tuberculosis. bioRxiv : the preprint server for biology, 2023.02.06.527416. https://doi.org/10.1101/2023.02.06.527416 |
| Greene, S. E., Huang, Y., Kim, W., Liebeskind, M. J., Chandrasekaran, V., Liu, Z., Deepak, P., Paley, M. A., Lew, D., Yang, M., Matloubian, M., Gensler, L. S., Nakamura, M. C., O’Hallaran, J. A., Presti, R. M., Whelan, S. P. J., Buchser, W. J., Kim, A. H. J., & Weil, G. J. (2023). A simple point-of-care assay accurately detects anti-spike antibodies after SARS-CoV-2 vaccination. Journal of clinical virology plus, 3(1), 100135. https://doi.org/10.1016/j.jcvp.2023.100135 |
| Chadchan, S. B., Naik, S. K., Popli, P., Talwar, C., Putluri, S., Ambati, C. R., Lint, M. A., Kau, A. L., Stallings, C. L., & Kommagani, R. (2023). Gut microbiota and microbiota-derived metabolites promotes endometriosis. Cell death discovery, 9(1), 28. https://doi.org/10.1038/s41420-023-01309-0 |
| Tamadonfar, K. O., Di Venanzio, G., Pinkner, J. S., Dodson, K. W., Kalas, V., Zimmerman, M. I., Bazan Villicana, J., Bowman, G. R., Feldman, M. F., &Hultgren, S. J. (2023). Structure-function correlates of fibrinogen binding by Acinetobacter adhesins critical in catheter-associated urinary tract infections. Proceedings of the National Academy of Sciences of the United States of America, 120(4), e2212694120. https://doi.org/10.1073/pnas.2212694120 |
| Hazen, J. E., Di Venanzio, G., Hultgren, S. J.,& Feldman, M. F.(2023). Catheterization of mice triggers resurgent urinary tract infection seeded by a bladder reservoir of Acinetobacter baumannii. Science translational medicine, 15(678), eabn8134. https://doi.org/10.1126/scitranslmed.abn8134 |
2022
| Lye, L. F., Owens, K. L., Jang, S., Marcus, J. E., Brettmann, E. A., & Beverley, S. M. (2022). An RNA Interference (RNAi) Toolkit and Its Utility for Functional Genetic Analysis of Leishmania (Viannia). Genes, 14(1), 93. https://doi.org/10.3390/genes14010093 |
| Wang, J. L., Li, T. T., Elsheikha, H. M., Liang, Q. L., Zhang, Z. W., Wang, M., Sibley, L. D., & Zhu, X. Q. (2022). The protein phosphatase 2A holoenzyme is a key regulator of starch metabolism and bradyzoite differentiation in Toxoplasma gondii. Nature communications, 13(1), 7560. https://doi.org/10.1038/s41467-022-35267-5 |
| Zeng, Q., Antia, A., Puray-Chavez, M., Kutluay, S. B., & Ding, S. (2022). Calpain-2 mediates SARS-CoV-2 entry and represents a therapeutic target. bioRxiv : the preprint server for biology, 2022.11.29.518418. https://doi.org/10.1101/2022.11.29.518418 |
| Cai, C. W., O’Shea, A., Eickhoff, C. S., Guo, H., Lewis, W. G., Beverley, S. M., & Hoft, D. F. (2022). Use of Leishmania major parasites expressing a recombinant Trypanosoma cruzi antigen as live vaccines against Chagas disease. Frontiers in microbiology, 13, 1059115. https://doi.org/10.3389/fmicb.2022.1059115 |
| Polanco, G., Scott, N. E., Lye, L. F., & Beverley, S. M. (2022). Expanded Proteomic Survey of the Human Parasite Leishmania major Focusing on Changes in Null Mutants of the Golgi GDP-Mannose/Fucose/Arabinopyranose Transporter LPG2 and of the Mitochondrial Fucosyltransferase FUT1. Microbiology spectrum, 10(6), e0305222. https://doi.org/10.1128/spectrum.03052-22 |
| Ferreira, T. R., Inbar, E., Shaik, J., Jeffrey, B. M., Ghosh, K., Dobson, D. E., Beverley, S. M., & Sacks, D. (2022). Self-Hybridization in Leishmania major. mBio, 13(6), e0285822. https://doi.org/10.1128/mbio.02858-22 |
| Park, Y. J., Pinto, D., Walls, A. C., Liu, Z., De Marco, A., Benigni, F., Zatta, F., Silacci-Fregni, C., Bassi, J., Sprouse, K. R., Addetia, A., Bowen, J. E., Stewart, C., Giurdanella, M., Saliba, C., Guarino, B., Schmid, M. A., Franko, N. M., Logue, J. K., Dang, H. V., … Veesler, D. (2022). Imprinted antibody responses against SARS-CoV-2 Omicron sublineages. Science (New York, N.Y.), 378(6620), 619–627. https://doi.org/10.1126/science.adc9127 |
| Casorla-Perez, L. A., Guennoun, R., Cubillas, C., Peng, B., Kornfeld, K., & Wang, D. (2022). Orsay Virus Infection of Caenorhabditis elegans Is Modulated by Zinc and Dependent on Lipids. Journal of virology, 96(22), e0121122. https://doi.org/10.1128/jvi.01211-22 |
| Fisher, D. G., Gnazzo, V., Holthausen, D. J., & López, C. B. (2022). Non-standard viral genome-derived RNA activates TLR3 and type I IFN signaling to induce cDC1-dependent CD8+ T-cell responses during vaccination in mice. Vaccine, 40(50), 7270–7279. https://doi.org/10.1016/j.vaccine.2022.10.052 |
| Mandell, M. A., Beatty, W. L., & Beverley, S. M. (2022). Quantitative single-cell analysis of Leishmania major amastigote differentiation demonstrates variably extended expression of the lipophosphoglycan (LPG) virulence factor in different host cell types. PLoS neglected tropical diseases, 16(10), e0010893. https://doi.org/10.1371/journal.pntd.0010893 |
| Nye, T. M., Tükenmez, H., Singh, P., Flores-Mireles, A. L., Obernuefemann, C. L. P., Pinkner, J. S., Sarkar, S., Bonde, M., Lindgren, A. E. G., Dodson, K. W., Johansson, J., Almqvist, F., Caparon, M. G., & Hultgren, S. J. (2022). Ring-fused 2-pyridones effective against multidrug-resistant Gram-positive pathogens and synergistic with standard-of-care antibiotics. Proceedings of the National Academy of Sciences of the United States of America, 119(43), e2210912119. https://doi.org/10.1073/pnas.2210912119 |
| Tükenmez, H., Nye, T. M., Bonde, M., Caparon, M. G., Almqvist, F., Hultgren, S. J., & Johansson, J. (2022). Complete Genome Sequence of the Uropathogenic Methicillin-Resistant Staphylococcus aureus Strain MRSA-1369. Microbiology resource announcements, 11(10), e0098122. https://doi.org/10.1128/mra.00981-22 |
| Kuhlmann, F. M., Key, P. N., Hickerson, S. M., Turk, J., Hsu, F. F., & Beverley, S. M. (2022). Inositol phosphorylceramide synthase null Leishmania are viable and virulent in animal infections where salvage of host sphingomyelin predominates. The Journal of biological chemistry, 298(11), 102522. https://doi.org/10.1016/j.jbc.2022.102522 |
2021
Old vaccines for new infections: Exploiting innate immunity to control COVID-19 and prevent future pandemics. Chumakov K, Avidan MS, Benn CS, Bertozzi SM, Blatt L, Chang AY, Jamison DT, Khader SA, Kottilil S, Netea MG, Sparrow A, Gallo RC. Proc Natl Acad Sci U S A. 2021 May 25;118(21):e2101718118. doi: 10.1073/pnas.2101718118. PMID: 34006644.
Cryo-EM structure of cortical microtubules from human parasite Toxoplasma gondii identifies their microtubule inner proteins. Wang X, Fu Y, Beatty WL, Ma M, Brown A, David Sibley L, Zhang R. Nat Commun. 2021 May 24;12(1):3065. doi: 10.1038/s41467-021-23351-1. PMID: 34031406.
Trained immunity, tolerance, priming and differentiation: distinct immunological processes. Divangahi M, Aaby P, Khader SA, Barreiro LB, Bekkering S, Chavakis T, van Crevel R, Curtis N, DiNardo AR, Dominguez-Andres J, Duivenvoorden R, Fanucchi S, Fayad Z, Fuchs E, Hamon M, Jeffrey KL, Khan N, Joosten LAB, Kaufmann E, Latz E, Matarese G, van der Meer JWM, Mhlanga M, Moorlag SJCFM, Mulder WJM, Naik S, Novakovic B, O’Neill L, Ochando J, Ozato K, Riksen NP, Sauerwein R, Sherwood ER, Schlitzer A, Schultze JL, Sieweke MH, Benn CS, Stunnenberg H, Sun J, van de Veerdonk FL, Weis S, Williams DL, Xavier R, Netea MG. Nat Immunol. 2021 Jan;22(1):2-6. doi: 10.1038/s41590-020-00845-6. Erratum in: Nat Immunol. 2021 May 20; PMID: 33293712; PMCID: PMC8020292.
Toxoplasma gondii secreted effectors co-opt host repressor complexes to inhibit necroptosis. Rosenberg A, Sibley LD. Cell Host Microbe. 2021 May 20:S1931-3128(21)00192-X. doi: 10.1016/j.chom.2021.04.016. Epub ahead of print. PMID: 34043960.
Broadly neutralizing monoclonal antibodies protect against multiple tick-borne flaviviruses. VanBlargan LA, Errico JM, Kafai NM, Burgomaster KE, Jethva PN, Broeckel RM, Meade-White K, Nelson CA, Himansu S, Wang D, Handley SA, Gross ML, Best SM, Pierson TC, Fremont DH, Diamond MS. J Exp Med. 2021 May 3;218(5):e20210174. doi: 10.1084/jem.20210174. PMID: 33831142; PMCID: PMC8040518.
Detection of respiratory syncytial virus defective genomes in nasal secretions is associated with distinct clinical outcomes. Felt SA, Sun Y, Jozwik A, Paras A, Habibi MS, Nickle D, Anderson L, Achouri E, Feemster KA, Cárdenas AM, Turi KN, Chang M, Hartert TV, Sengupta S, Chiu C, López CB. Nat Microbiol. 2021 May;6(5):672-681. doi: 10.1038/s41564-021-00882-3. PMID: 33795879.
N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2. McCallum M, De Marco A, Lempp FA, Tortorici MA, Pinto D, Walls AC, Beltramello M, Chen A, Liu Z, Zatta F, Zepeda S, di Iulio J, Bowen JE, Montiel-Ruiz M, Zhou J, Rosen LE, Bianchi S, Guarino B, Fregni CS, Abdelnabi R, Foo SC, Rothlauf PW, Bloyet LM, Benigni F, Cameroni E, Neyts J, Riva A, Snell G, Telenti A, Whelan SPJ, Virgin HW, Corti D, Pizzuto MS, Veesler D. Cell. 2021 Apr 29;184(9):2332-2347.e16. doi: 10.1016/j.cell.2021.03.028. PMID: 33761326; PMCID: PMC7962585.
Phenotype of Peripheral NK Cells in Latent, Active, and Meningeal Tuberculosis. Choreño-Parra JA, Jiménez-Álvarez LA, Maldonado-Díaz ED, Cárdenas G, Fernández-Lopez LA, Soto-Hernandez JL, Muñoz-Torrico M, Ramírez-Martínez G, Cruz-Lagunas A, Vega-López A, Domínguez-López ML, Sánchez-Garibay C, Guadarrama-Ortíz P, Giono S, Jiménez-Zamudio LA, Khader SA, García-Latorre EA, Salinas-Lara C, Zúñiga J. J Immunol Res. 2021 Apr 27;2021:5517856. doi: 10.1155/2021/5517856. PMID: 34007850; PMCID: PMC8100419.
SARS-CoV-2 E gene variant alters analytical sensitivity characteristics of viral detection using a commercial RT-PCR assay. Tahan S, Parikh BA, Droit L, Wallace MA, Burnham CA, Wang D. J Clin Microbiol. 2021 Apr 26:JCM.00075-21. doi: 10.1128/JCM.00075-21. PMID: 33903167.
Clinical and Immunological Factors That Distinguish COVID-19 From Pandemic Influenza A(H1N1). Choreño-Parra JA, Jiménez-Álvarez LA, Cruz-Lagunas A, Rodríguez-Reyna TS, Ramírez-Martínez G, Sandoval-Vega M, Hernández-García DL, Choreño-Parra EM, Balderas-Martínez YI, Martinez-Sánchez ME, Márquez-García E, Sciutto E, Moreno-Rodríguez J, Barreto-Rodríguez JO, Vázquez-Rojas H, Centeno-Sáenz GI, Alvarado-Peña N, Salinas-Lara C, Sánchez-Garibay C, Galeana-Cadena D, Hernández G, Mendoza-Milla C, Domínguez A, Granados J, Mena-Hernández L, Pérez-Buenfil LÁ, Domínguez-Cheritt G, Cabello-Gutiérrez C, Luna-Rivero C, Salas-Hernández J, Santillán-Doherty P, Regalado J, Hernández-Martínez A, Orozco L, Ávila-Moreno F, García-Latorre EA, Hernández-Cárdenas CM, Khader SA, Zlotnik A, Zúñiga J. Front Immunol. 2021 Apr 21;12:593595. doi: 10.3389/fimmu.2021.593595. PMID: 33995342; PMCID: PMC8115405.
Too much of a good thing: Overproduction of virulence factors impairs cryptococcal pathogenicity. Reuwsaat JCV, Doering TL, Kmetzsch L.. Microb Cell. 2021 Apr 20;8(5):108-110. doi: 10.15698/mic2021.05.750. PMID: 33981763; PMCID: PMC8080896.
Monocyte progenitors give rise to multinucleated giant cells. Lösslein AK, Lohrmann F, Scheuermann L, Gharun K, Neuber J, Kolter J, Forde AJ, Kleimeyer C, Poh YY, Mack M, Triantafyllopoulou A, Dunlap MD, Khader SA, Seidl M, Hölscher A, Hölscher C, Guan XL, Dorhoi A, Henneke P. Nat Commun. 2021 Apr 1;12(1):2027. doi: 10.1038/s41467-021-22103-5. PMID: 33795674; PMCID: PMC8016882.
Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies. Chen RE, Zhang X, Case JB, Winkler ES, Liu Y, VanBlargan LA, Liu J, Errico JM, Xie X, Suryadevara N, Gilchuk P, Zost SJ, Tahan S, Droit L, Turner JS, Kim W, Schmitz AJ, Thapa M, Wang D, Boon ACM, Presti RM, O’Halloran JA, Kim AHJ, Deepak P, Pinto D, Fremont DH, Crowe JE Jr, Corti D, Virgin HW, Ellebedy AH, Shi PY, Diamond MS. Nat Med. 2021 Apr;27(4):717-726. doi: 10.1038/s41591-021-01294-w. PMID: 33664494; PMCID: PMC8058618.
The antioxidant response favors Leishmania parasites survival, limits inflammation and reprograms the host cell metabolism. Reverte M, Eren RO, Jha B, Desponds C, Snäkä T, Prevel F, Isorce N, Lye LF, Owens KL, Gazos Lopes U, Beverley SM, Fasel N. PLoS Pathog. 2021 Mar 25;17(3):e1009422. doi: 10.1371/journal.ppat.1009422. PMID: 33765083; PMCID: PMC7993605.
CARD8 is an inflammasome sensor for HIV-1 protease activity. Wang Q, Gao H, Clark KM, Mugisha CS, Davis K, Tang JP, Harlan GH, DeSelm CJ, Presti RM, Kutluay SB, Shan L. Science. 2021 Mar 19;371(6535):eabe1707. doi: 10.1126/science.abe1707. PMID: 33542150; PMCID: PMC8029496.
N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2. McCallum M, De Marco A, Lempp FA, Tortorici MA, Pinto D, Walls AC, Beltramello M, Chen A, Liu Z, Zatta F, Zepeda S, di Iulio J, Bowen JE, Montiel-Ruiz M, Zhou J, Rosen LE, Bianchi S, Guarino B, Fregni CS, Abdelnabi R, Foo SC, Rothlauf PW, Bloyet LM, Benigni F, Cameroni E, Neyts J, Riva A, Snell G, Telenti A, Whelan SPJ, Virgin HW, Corti D, Pizzuto MS, Veesler D. N. Cell. 2021 Apr 29;184(9):2332-2347.e16. doi: 10.1016/j.cell.2021.03.028. Epub 2021 Mar 16. PMID: 33761326; PMCID: PMC7962585.
Identification of SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization. Liu Z, VanBlargan LA, Bloyet LM, Rothlauf PW, Chen RE, Stumpf S, Zhao H, Errico JM, Theel ES, Liebeskind MJ, Alford B, Buchser WJ, Ellebedy AH, Fremont DH, Diamond MS, Whelan SPJ. Cell Host Microbe. 2021 Mar 10;29(3):477-488.e4. doi: 10.1016/j.chom.2021.01.014. PMID: 33535027; PMCID: PMC7839837.
The Transcription Factor Pdr802 Regulates Titan Cell Formation and Pathogenicity of Cryptococcus neoformans. Reuwsaat JCV, Agustinho DP, Motta H, Chang AL, Brown H, Brent MR, Kmetzsch L, Doering TL. mBio. 2021 Mar 9;12(2):e03457-20. doi: 10.1128/mBio.03457-20. PMID: 33688010; PMCID: PMC8092302.
Insulinase-like Protease 1 Contributes to Macrogamont Formation in Cryptosporidium parvum. Xu R, Feng Y, Xiao L, Sibley LD. mBio. 2021 Mar 9;12(2):e03405-20. doi: 10.1128/mBio.03405-20. PMID: 33688009; PMCID: PMC8092296.
IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection. Rosa BA, Ahmed M, Singh DK, Choreño-Parra JA, Cole J, Jiménez-Álvarez LA, Rodríguez-Reyna TS, Singh B, Gonzalez O, Carrion R Jr, Schlesinger LS, Martin J, Zúñiga J, Mitreva M, Khader SA, Kaushal D. Commun Biol. 2021 Mar 5;4(1):290. doi: 10.1038/s42003-021-01829-4. PMID: 33674719; PMCID: PMC7935909.
Responses to acute infection with SARS-CoV-2 in the lungs of rhesus macaques, baboons and marmosets. Singh DK, Singh B, Ganatra SR, Gazi M, Cole J, Thippeshappa R, Alfson KJ, Clemmons E, Gonzalez O, Escobedo R, Lee TH, Chatterjee A, Goez-Gazi Y, Sharan R, Gough M, Alvarez C, Blakley A, Ferdin J, Bartley C, Staples H, Parodi L, Callery J, Mannino A, Klaffke B, Escareno P, Platt RN 2nd, Hodara V, Scordo J, Gautam S, Vilanova AG, Olmo-Fontanez A, Schami A, Oyejide A, Ajithdoss DK, Copin R, Baum A, Kyratsous C, Alvarez X, Ahmed M, Rosa B, Goodroe A, Dutton J, Hall-Ursone S, Frost PA, Voges AK, Ross CN, Sayers K, Chen C, Hallam C, Khader SA, Mitreva M, Anderson TJC, Martinez-Sobrido L, Patterson JL, Turner J, Torrelles JB, Dick EJ Jr, Brasky K, Schlesinger LS, Giavedoni LD, Carrion R Jr, Kaushal D. Author Correction: Nat Microbiol. 2021 Mar;6(3):413. doi: 10.1038/s41564-021-00867-2. Erratum for: Nat Microbiol. 2021 Jan;6(1):73-86. PMID: 33462437; PMCID: PMC7812341.
IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection. Rosa BA, Ahmed M, Singh DK, Choreño-Parra JA, Cole J, Jiménez-Álvarez LA, Rodríguez-Reyna TS, Singh B, Gonzalez O, Carrion R Jr, Schlesinger LS, Martin J, Zúñiga J, Mitreva M, Kaushal D, Khader SA. Commun Biol. 2021 Mar 5;4(1):290. doi: 10.1038/s42003-021-01829-4. PMID: 33674719; PMCID: PMC7935909.
Expression of Surfactant protein D (SP-D) distinguishes severe pandemic influenza A(H1N1) from COVID-19. Choreño-Parra JA, Jiménez-Álvarez LA, Ramírez-Martínez G, Cruz-Lagunas A, Thapa M, Fernández-López LA, Carnalla-Cortés M, Choreño-Parra EM, Mena-Hernández L, Sandoval-Vega M, Hernández-Montiel EM, Hernández-García DL, Ramírez-Noyola JA, Reyes-López CE, Domínguez-Faure A, Zamudio-López GY, Márquez-García E, Moncada-Morales A, Mendoza-Milla C, Cervántes-Rosete D, Muñoz-Torrico M, Luna-Rivero C, García-Latorre EA, Guadarrama-Ortíz P, Ávila-Moreno F, Domínguez-Cherit G, Rodríguez-Reyna TS, Mudd PA, Hernández-Cárdenas CM, Khader SA, Zúñiga J. J Infect Dis. 2021 Mar 1:jiab113. doi: 10.1093/infdis/jiab113. Epub ahead of print. PMID: 33668070; PMCID: PMC7989215.
Endogenization of a Prosimian Retrovirus during Lemur Evolution. Apakupakul K, Deem SL, Maqsood R, Sithiyopasakul P, Wang D, Lim ES. Viruses. 2021 Feb 27;13(3):383. doi: 10.3390/v13030383. PMID: 33673677; PMCID: PMC7997422.
CXCL17 Is a Specific Diagnostic Biomarker for Severe Pandemic Influenza A(H1N1) That Predicts Poor Clinical Outcome. Choreño-Parra JA, Jiménez-Álvarez LA, Ramírez-Martínez G, Sandoval-Vega M, Salinas-Lara C, Sánchez-Garibay C, Luna-Rivero C, Hernández-Montiel EM, Fernández-López LA, Cabrera-Cornejo MF, Choreño-Parra EM, Cruz-Lagunas A, Domínguez A, Márquez-García E, Cabello-Gutiérrez C, Bolaños-Morales FV, Mena-Hernández L, Delgado-Zaldivar D, Rebolledo-García D, Guadarrama-Ortiz P, Regino-Zamarripa NE, Mendoza-Milla C, García-Latorre EA, Rodiguez-Reyna TS, Cervántes-Rosete D, Hernández-Cárdenas CM, Khader SA, Zlotnik A, Zúñiga J. Front Immunol. 2021 Feb 26;12:633297. doi: 10.3389/fimmu.2021.633297. PMID: 33717172; PMCID: PMC7953906.
Toxoplasma gondii infection and its implications within the central nervous system. Matta SK, Rinkenberger N, Dunay IR, Sibley LD. Nat Rev Microbiol. 2021 Feb 24. doi: 10.1038/s41579-021-00518-7. Epub ahead of print. PMID: 33627834.
Limited effects of long-term daily cranberry consumption on the gut microbiome in a placebo-controlled study of women with recurrent urinary tract infections. Straub TJ, Chou WC, Manson AL, Schreiber HL 4th, Walker BJ, Desjardins CA, Chapman SB, Kaspar KL, Kahsai OJ, Traylor E, Dodson KW, Hullar MAJ, Hultgren SJ, Khoo C, Earl AM. BMC Microbiol. 2021 Feb 18;21(1):53. doi: 10.1186/s12866-021-02106-4. PMID: 33596852; PMCID: PMC7890861.
The immune landscape in tuberculosis reveals populations linked to disease and latency. Esaulova E, Das S, Singh DK, Choreño-Parra JA, Swain A, Arthur L, Rangel-Moreno J, Ahmed M, Singh B, Gupta A, Fernández-López LA, de la Luz Garcia-Hernandez M, Bucsan A, Moodley C, Mehra S, García-Latorre E, Zuniga J, Atkinson J, Kaushal D, Artyomov MN, Khader SA. Cell Host Microbe. 2021 Feb 10;29(2):165-178.e8. doi: 10.1016/j.chom.2020.11.013. PMID: 33340449; PMCID: PMC7878437.
Seroprevalence of SARS-CoV-2 Antibodies in Children and Adults in St. Louis, Missouri, USA. Smith BK, Janowski AB, Danis JE, Harvey IB, Zhao H, Dai YN, Farnsworth CW, Gronowski AM, Roper S, Fremont DH, Wang D. mSphere. 2021 Feb 3;6(1):e01207-20. doi: 10.1128/mSphere.01207-20. PMID: 33536325; PMCID: PMC7860990.
A host receptor enables type 1 pilus-mediated pathogenesis of Escherichia coli pyelonephritis. McLellan LK, McAllaster MR, Kim AS, Tóthová Ľ, Olson PD, Pinkner JS, Daugherty AL, Hreha TN, Janetka JW, Fremont DH, Hultgren SJ, Virgin HW, Hunstad DA. PLoS Pathog. 2021 Jan 29;17(1):e1009314. doi: 10.1371/journal.ppat.1009314. PMID: 33513212; PMCID: PMC7875428.
Leishmania Sexual Reproductive Strategies as Resolved through Computational Methods Designed for Aneuploid Genomes. Genes (Basel). Shaik JS, Dobson DE, Sacks DL, Beverley SM. 2021 Jan 26;12(2):167. doi: 10.3390/genes12020167. PMID: 33530584; PMCID: PMC7912377.
Perspectives and Advances in the Understanding of Tuberculosis. Kinsella RL, Zhu DX, Harrison GA, Mayer Bridwell AE, Prusa J, Chavez SM, Stallings CL. Annu Rev Pathol. 2021 Jan 24;16:377-408. doi: 10.1146/annurev-pathol-042120-032916. PMID: 33497258.
Mycobacterium tuberculosis Rv3160c is a TetR-like transcriptional repressor that regulates expression of the putative oxygenase Rv3161c. Tükenmez H, Sarkar S, Anoosheh S, Kruchanova A, Edström I, Harrison GA, Stallings CL, Almqvist F, Larsson C. Sci Rep. 2021 Jan 15;11(1):1523. doi: 10.1038/s41598-021-81104-y. PMID: 33452380; PMCID: PMC7810876.
Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding Domain that Escape Antibody Recognition. Greaney AJ, Starr TN, Gilchuk P, Zost SJ, Binshtein E, Loes AN, Hilton SK, Huddleston J, Eguia R, Crawford KHD, Dingens AS, Nargi RS, Sutton RE, Suryadevara N, Rothlauf PW, Liu Z, Whelan SPJ, Carnahan RH, Crowe JE Jr, Bloom JD. Cell Host Microbe. 2021 Jan 13;29(1):44-57.e9. doi: 10.1016/j.chom.2020.11.007. PMID: 33259788; PMCID: PMC7676316.
SARS-CoV-2 Viral RNA Shedding for More Than 87 Days in an Individual With an Impaired CD8+ T Cell Response. Turner JS, Day A, Alsoussi WB, Liu Z, O’Halloran JA, Presti RM, Patterson BK, Whelan SPJ, Ellebedy AH, Mudd PA. Front Immunol. 2021 Jan 8;11:618402. doi: 10.3389/fimmu.2020.618402. PMID: 33488630; PMCID: PMC7820941.
UFMylation inhibits the proinflammatory capacity of interferon-γ-activated macrophages. Balce DR, Wang YT, McAllaster MR, Dunlap BF, Orvedahl A, Hykes BL Jr, Droit L, Handley SA, Wilen CB, Doench JG, Orchard RC, Stallings CL, Virgin HW. Proc Natl Acad Sci U S A. 2021 Jan 5;118(1):e2011763118. doi: 10.1073/pnas.2011763118. PMID: 33372156; PMCID: PMC7817147.
2020
Capsid Lattice Destabilization Leads to Premature Loss of the Viral Genome and Integrase Enzyme during HIV-1 Infection. Eschbach JE, Elliott JL, Li W, Zadrozny KK, Davis K, Mohammed SJ, Lawson DQ, Pornillos O, Engelman AN, Kutluay SB. J Virol. 2020 Dec 22;95(2):e00984-20. doi: 10.1128/JVI.00984-20. PMID: 33115869; PMCID: PMC7944438.
Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion. Zang R, Case JB, Yutuc E, Ma X, Shen S, Gomez Castro MF, Liu Z, Zeng Q, Zhao H, Son J, Rothlauf PW, Kreutzberger AJB, Hou G, Zhang H, Bose S, Wang X, Vahey MD, Mani K, Griffiths WJ, Kirchhausen T, Fremont DH, Guo H, Diwan A, Wang Y, Diamond MS, Whelan SPJ, Ding S. Proc Natl Acad Sci U S A. 2020 Dec 15;117(50):32105-32113. doi: 10.1073/pnas.2012197117. PMID: 33239446; PMCID: PMC7749331.
Neonatal Mouse Gut Metabolites Influence Cryptosporidium parvum Infection in Intestinal Epithelial Cells. VanDussen KL, Funkhouser-Jones LJ, Akey ME, Schaefer DA, Ackman K, Riggs MW, Stappenbeck TS, Sibley LD. mBio. 2020 Dec 15;11(6):e02582-20. doi: 10.1128/mBio.02582-20. PMID: 33323514; PMCID: PMC7773987.
Structure of the Receptor Binding Domain of EnvP(b)1, an Endogenous Retroviral Envelope Protein Expressed in Human Tissues. McCarthy KR, Timpona JL, Jenni S, Bloyet LM, Brusic V, Johnson WE, Whelan SPJ, Robinson-McCarthy LR. mBio. 2020 Nov 17;11(6):e02772-20. doi: 10.1128/mBio.02772-20. PMID: 33203760; PMCID: PMC7683403.
Clip for studying protein-RNA interactions that regulate virus replication. Shema Mugisha C, Tenneti K, Kutluay SB. Methods. 2020 Nov 1;183:84-92. doi: 10.1016/j.ymeth.2019.11.011. PMID: 31765715; PMCID: PMC6963001.
Dangerous Liaisons: Interactions of Cryptococcus neoformans with Host Phagocytes. Gaylord EA, Choy HL, Doering TL. Pathogens. 2020 Oct 27;9(11):891. doi: 10.3390/pathogens9110891. PMID: 33121050; PMCID: PMC7692806.
Orsay Virus CP-δ Adopts a Novel β-Bracelet Structural Fold and Incorporates into Virions as a Head Fiber. Guo YR, Fan Y, Zhou Y, Jin M, Zhang JL, Jiang H, Holt MV, Wang T, Young NL, Wang D, Zhong W, Tao YJ. J Virol. 2020 Oct 14;94(21):e01560-20. doi: 10.1128/JVI.01560-20. PMID: 32817218; PMCID: PMC7565637.
Latent-transforming growth factor beta-binding protein-2 (LTBP-2) is required for longevity but not for development of zonular fibers. Shi Y, Jones W, Beatty W, Tan Q, Mecham RP, Kumra H, Reinhardt DP, Gibson MA, Reilly MA, Rodriguez J, Bassnett S. Matrix Biol. 2020 Oct 9:S0945-053X(20)30092-5. doi: 10.1016/j.matbio.2020.10.002. PMID: 33039488.
ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells. Bhushan J, Radke JB, Perng YC, Mcallaster M, Lenschow DJ, Virgin HW, Sibley LD. mBio. 2020 Oct 6;11(5):e00852-20. doi: 10.1128/mBio.00852-20. PMID: 33024031; PMCID: PMC7542356.
Antiretroviral therapy does not reduce tuberculosis reactivation in a tuberculosis-HIV coinfection model. Ganatra SR, Bucşan AN, Alvarez X, Kumar S, Chatterjee A, Quezada M, Fish A, Singh DK, Singh B, Sharan R, Lee TH, Shanmugasundaram U, Velu V, Khader SA, Mehra S, Rengarajan J, Kaushal D. J Clin Invest. 2020 Oct 1;130(10):5171-5179. doi: 10.1172/JCI136502. PMID: 32544085; PMCID: PMC7524506.
Immunometabolism during Mycobacterium tuberculosis Infection. Howard NC, Khader SA. Trends Microbiol. 2020 Oct;28(10):832-850. doi: 10.1016/j.tim.2020.04.010. Epub 2020 May 11. PMID: 32409147; PMCID: PMC7494650.
When STING Meets Viruses: Sensing, Trafficking and Response. Li Z, Cai S, Sun Y, Li L, Ding S, Wang X. Front Immunol. 2020 Sep 29;11:2064. doi: 10.3389/fimmu.2020.02064. PMID: 33133062; PMCID: PMC7550420.
Adaptation of Arginine Synthesis among Uropathogenic Branches of the Escherichia coli Phylogeny Reveals Adjustment to the Urinary Tract Habitat. Hibbing ME, Dodson KW, Kalas V, Chen SL, Hultgren SJ. mBio. 2020 Sep 29;11(5):e02318-20. doi: 10.1128/mBio.02318-20. PMID: 32994329; PMCID: PMC7527732.
Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis. Elliott JL, Eschbach JE, Koneru PC, Li W, Puray-Chavez M, Townsend D, Lawson DQ, Engelman AN, Kvaratskhelia M, Kutluay SB. Elife. 2020 Sep 22;9:e54311. doi: 10.7554/eLife.54311. PMID: 32960169; PMCID: PMC7671690.
A Flexible and Deadly Way to Control Salmonella Infection Kinsella RL, Stallings CL.. Immunity. 2020 Sep 15;53(3):471-473. doi: 10.1016/j.immuni.2020.08.009. PMID: 32937145.
Neutralizing Antibody and Soluble ACE2 Inhibition of a Replication-Competent VSV-SARS-CoV-2 and a Clinical Isolate of SARS-CoV-2. Case JB, Rothlauf PW, Chen RE, Liu Z, Zhao H, Kim AS, Bloyet LM, Zeng Q, Tahan S, Droit L, Ilagan MXG, Tartell MA, Amarasinghe G, Henderson JP, Miersch S, Ustav M, Sidhu S, Virgin HW, Wang D, Ding S, Corti D, Theel ES, Fremont DH, Diamond MS, Whelan SPJ.. Cell Host Microbe. 2020 Sep 9;28(3):475-485.e5. doi: 10.1016/j.chom.2020.06.021. PMID: 32735849; PMCID: PMC7332453.
Replication-Competent Vesicular Stomatitis Virus Vaccine Vector Protects against SARS-CoV-2-Mediated Pathogenesis in Mice. Case JB, Rothlauf PW, Chen RE, Kafai NM, Fox JM, Smith BK, Shrihari S, McCune BT, Harvey IB, Keeler SP, Bloyet LM, Zhao H, Ma M, Adams LJ, Winkler ES, Holtzman MJ, Fremont DH, Whelan SPJ, Diamond MS. Cell Host Microbe. 2020 Sep 9;28(3):465-474.e4. doi: 10.1016/j.chom.2020.07.018. Epub 2020 Jul 30. PMID: 32798445; PMCID: PMC7391951.
Going beyond Integration: The Emerging Role of HIV-1 Integrase in Virion Morphogenesis. Elliott JL, Kutluay SB. Viruses. 2020 Sep 9;12(9):1005. doi: 10.3390/v12091005. PMID: 32916894; PMCID: PMC7551943.
Huntingtin-interacting protein family members have a conserved pro-viral function from Caenorhabditis elegans to humans. Jiang H, Sandoval Del Prado LE, Leung C, Wang D. Proc Natl Acad Sci U S A. 2020 Sep 8;117(36):22462-22472. doi: 10.1073/pnas.2006914117. PMID: 32839311; PMCID: PMC7486723.
A Simplified Quantitative Real-Time PCR Assay for Monitoring SARS-CoV-2 Growth in Cell Culture. Shema Mugisha C, Vuong HR, Puray-Chavez M, Bailey AL, Fox JM, Chen RE, Wessel AW, Scott JM, Harastani HH, Boon ACM, Shin H, Kutluay SB. mSphere. 2020 Sep 2;5(5):e00658-20. doi: 10.1128/mSphere.00658-20. PMID: 32878932; PMCID: PMC7471006.
A facile Q-RT-PCR assay for monitoring SARS-CoV-2 growth in cell culture. Mugisha CS, Vuong HR, Puray-Chavez M, Kutluay SB. bioRxiv [Preprint]. 2020 Jun 28:2020.06.26.174698. doi: 10.1101/2020.06.26.174698. Update in: mSphere. 2020 Sep 2;5(5): PMID: 32607508; PMCID: PMC7325174.
High-resolution imaging reveals microbial biofilms on patient urinary catheters despite antibiotic administration. Walker JN, Flores-Mireles AL, Lynch AJL, Pinkner C, Caparon MG, Hultgren SJ, Desai A. World J Urol. 2020 Sep;38(9):2237-2245. doi: 10.1007/s00345-019-03027-8. PMID: 31792577; PMCID: PMC7778452.
Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein. Zost SJ, Gilchuk P, Chen RE, Case JB, Reidy JX, Trivette A, Nargi RS, Sutton RE, Suryadevara N, Chen EC, Binshtein E, Shrihari S, Ostrowski M, Chu HY, Didier JE, MacRenaris KW, Jones T, Day S, Myers L, Eun-Hyung Lee F, Nguyen DC, Sanz I, Martinez DR, Rothlauf PW, Bloyet LM, Whelan SPJ, Baric RS, Thackray LB, Diamond MS, Carnahan RH, Crowe JE Jr. Nat Med. 2020 Sep;26(9):1422-1427. doi: 10.1038/s41591-020-0998-x. PMID: 32651581.
Optimized Reverse Genetics System Suitable for Efficient Recovery of Simian, Human, and Murine-Like Rotaviruses. Sánchez-Tacuba L, Feng N, Meade NJ, Mellits KH, Jaïs PH, Yasukawa LL, Resch TK, Jiang B, López S, Ding S, Greenberg HB. An J Virol. 2020 Aug 31;94(18):e01294-20. doi: 10.1128/JVI.01294-20. PMID: 32759316; PMCID: PMC7459567.
Chronic Immune Activation in TB/HIV Co-infection: (Trends in Microbiology 28, 619-632; 2020). Sharan R, Bucşan AN, Ganatra S, Paiardini M, Mohan M, Mehra S, Khader SA, Kaushal D. Trends Microbiol. 2020 Aug;28(8):699. doi: 10.1016/j.tim.2020.05.006. Erratum for: Trends Microbiol. 2020 Aug;28(8):619-632. PMID: 32482557.
The Viral Polymerase Complex Mediates the Interaction of Viral Ribonucleoprotein Complexes with Recycling Endosomes during Sendai Virus Assembly. Genoyer E, Kulej K, Hung CT, Thibault PA, Azarm K, Takimoto T, Garcia BA, Lee B, Lakdawala S, Weitzman MD, López CB. mBio. 2020 Aug 25;11(4):e02028-20. doi: 10.1128/mBio.02028-20. PMID: 32843550; PMCID: PMC7448285.
A cross-reactive antibody protects against Ross River virus musculoskeletal disease despite rapid neutralization escape in mice. Fox JM, Huang L, Tahan S, Powell LA, Crowe JE Jr, Wang D, Diamond MS. PLoS Pathog. 2020 Aug 6;16(8):e1008743. doi: 10.1371/journal.ppat.1008743. PMID: 32760128; PMCID: PMC7433899.
Targeting Unconventional Host Components for Vaccination-Induced Protection Against TB. Nemes E, Khader SA, Swanson RV, Hanekom WA. Front Immunol. 2020 Jul 24;11:1452. doi: 10.3389/fimmu.2020.01452. PMID: 32793199; PMCID: PMC7393005.
Cryptococcus neoformans Evades Pulmonary Immunity by Modulating Xylose Precursor Transport. Li LX, Hole CR, Rangel-Moreno J, Khader SA, Doering TL. Infect Immun. 2020 Jul 21;88(8):e00288-20. doi: 10.1128/IAI.00288-20. PMID: 32423915; PMCID: PMC7375766.
An Important Role for CD4+ T Cells in Adaptive Immunity to Toxoplasma gondii in Mice Lacking the Transcription Factor Batf3. Tussiwand R, Behnke MS, Kretzer NM, Grajales-Reyes GE, Murphy TL, Schreiber RD, Murphy KM, Sibley LD. mSphere. 2020 Jul 15;5(4):e00634-20. doi: 10.1128/mSphere.00634-20. PMID: 32669460; PMCID: PMC7364223.
Is SARS-CoV-2 Also an Enteric Pathogen With Potential Fecal-Oral Transmission? A COVID-19 Virological and Clinical Review. Ding S, Liang TJ. Gastroenterology. 2020 Jul;159(1):53-61. doi: 10.1053/j.gastro.2020.04.052. PMID: 32353371; PMCID: PMC7184994.
Retinoic Acid and Lymphotoxin Signaling Promote Differentiation of Human Intestinal M Cells. Ding S, Song Y, Brulois KF, Pan J, Co JY, Ren L, Feng N, Yasukawa LL, Sánchez-Tacuba L, Wosen JE, Mellins ED, Monack DM, Amieva MR, Kuo CJ, Butcher EC, Greenberg HB. Gastroenterology. 2020 Jul;159(1):214-226.e1. doi: 10.1053/j.gastro.2020.03.053. PMID: 32247021; PMCID: PMC7569531.
Formation of Lung Inducible Bronchus Associated Lymphoid Tissue Is Regulated by Mycobacterium tuberculosis Expressed Determinants. Dunlap MD, Prince OA, Rangel-Moreno J, Thomas KA, Scordo JM, Torrelles JB, Cox J, Steyn AJC, Zúñiga J, Kaushal D, Khader SA. Front Immunol. 2020 Jun 30;11:1325. doi: 10.3389/fimmu.2020.01325. PMID: 32695111; PMCID: PMC7338767.
Oligomerization of the Vesicular Stomatitis Virus Phosphoprotein Is Dispensable for mRNA Synthesis but Facilitates RNA Replication. Bloyet LM, Morin B, Brusic V, Gardner E, Ross RA, Vadakkan T, Kirchhausen T, Whelan SPJ. J Virol. 2020 Jun 16;94(13):e00115-20. doi: 10.1128/JVI.00115-20. PMID: 32321813; PMCID: PMC7307139.
Optimizing Pyrazolopyrimidine Inhibitors of Calcium Dependent Protein Kinase 1 for Treatment of Acute and Chronic Toxoplasmosis. Janetka JW, Hopper AT, Yang Z, Barks J, Dhason MS, Wang Q, Sibley LD. J Med Chem. 2020 Jun 11;63(11):6144-6163. doi: 10.1021/acs.jmedchem.0c00419. Epub 2020 Jun 1. PMID: 32420739; PMCID: PMC7325724.
COVID-19: viral-host interactome analyzed by network based-approach model to study pathogenesis of SARS-CoV-2 infection. Messina F, Giombini E, Agrati C, Vairo F, Ascoli Bartoli T, Al Moghazi S, Piacentini M, Locatelli F, Kobinger G, Maeurer M, Zumla A, Capobianchi MR, Lauria FN, Ippolito G; COVID 19 INMI Network Medicine for IDs Study Group. J Transl Med. 2020 Jun 10;18(1):233. doi: 10.1186/s12967-020-02405-w. PMID: 32522207; PMCID: PMC7286221.
Therapies for tuberculosis and AIDS: myeloid-derived suppressor cells in focus. Dorhoi A, Kotzé LA, Berzofsky JA, Sui Y, Gabrilovich DI, Garg A, Hafner R, Khader SA, Schaible UE, Kaufmann SH, Walzl G, Lutz MB, Mahon RN, Ostrand-Rosenberg S, Bishai W, du Plessis N. J Clin Invest. 2020 Jun 1;130(6):2789-2799. doi: 10.1172/JCI136288. PMID: 32420917; PMCID: PMC7260010.
S100A8/A9 regulates CD11b expression and neutrophil recruitment during chronic tuberculosis. Scott NR, Swanson RV, Al-Hammadi N, Domingo-Gonzalez R, Rangel-Moreno J, Kriel BA, Bucsan AN, Das S, Ahmed M, Mehra S, Treerat P, Cruz-Lagunas A, Jimenez-Alvarez L, Muñoz-Torrico M, Bobadilla-Lozoya K, Vogl T, Walzl G, du Plessis N, Kaushal D, Scriba TJ, Zúñiga J, Khader SA. J Clin Invest. 2020 Jun 1;130(6):3098-3112. doi: 10.1172/JCI130546. PMID: 32134742; PMCID: PMC7259997.
The protective and pathogenic roles of CXCL17 in human health and disease: Potential in respiratory medicine. Choreño-Parra JA, Thirunavukkarasu S, Zúñiga J, Khader SA. Cytokine Growth Factor Rev. 2020 Jun;53:53-62. doi: 10.1016/j.cytogfr.2020.04.004. PMID: 32345516; PMCID: PMC7177079.
Chronic Immune Activation in TB/HIV Co-infection. Sharan R, Bucşan AN, Ganatra S, Paiardini M, Mohan M, Mehra S, Khader SA, Kaushal D. Trends Microbiol. 2020 Aug;28(8):619-632. doi: 10.1016/j.tim.2020.03.015. Epub 2020 Apr 22. Erratum in: Trends Microbiol. 2020 May 29;: PMID: 32417227; PMCID: PMC7390597.
Structural basis for effector protein recognition by the Dot/Icm Type IVB coupling protein complex. Kim H, Kubori T, Yamazaki K, Kwak MJ, Park SY, Nagai H, Vogel JP, Oh BH. Nat Commun. 2020 May 26;11(1):2623. doi: 10.1038/s41467-020-16397-0. PMID: 32457311; PMCID: PMC7251119
TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes. Zang R, Gomez Castro MF, McCune BT, Zeng Q, Rothlauf PW, Sonnek NM, Liu Z, Brulois KF, Wang X, Greenberg HB, Diamond MS, Ciorba MA, Whelan SPJ, Ding S. Sci Immunol. 2020 May 13;5(47):eabc3582. doi: 10.1126/sciimmunol.abc3582. PMID: 32404436; PMCID: PMC7285829.
Mycobacterium tuberculosis HN878 Infection Induces Human-Like B-Cell Follicles in Mice. Choreño-Parra JA, Bobba S, Rangel-Moreno J, Ahmed M, Mehra S, Rosa B, Martin J, Mitreva M, Kaushal D, Zúñiga J, Khader SA. J Infect Dis. 2020 Apr 27;221(10):1636-1646. doi: 10.1093/infdis/jiz663. PMID: 31832640; PMCID: PMC7184917.
Genetics Reveals a Role of Rotavirus VP3 Phosphodiesterase Activity in Inhibiting RNase L Signaling and Contributing to Intestinal Viral Replication In Vivo. Song Y, Feng N, Sanchez-Tacuba L, Yasukawa LL, Ren L, Silverman RH, Ding S, Greenberg HB. Reverse J Virol. 2020 Apr 16;94(9):e01952-19. doi: 10.1128/JVI.01952-19. PMID: 32051268; PMCID: PMC7163120.
Establishment and Characterization of Bacterial Infection of Breast Implants in a Murine Model. Walker JN, Poppler LH, Pinkner CL, Hultgren SJ, Myckatyn TM. Aesthet Surg J. 2020 Apr 14;40(5):516-528. doi: 10.1093/asj/sjz190. PMID: 31259380.
Urinary tract infections: microbial pathogenesis, host-pathogen interactions and new treatment strategies. Klein RD, Hultgren SJ. Nat Rev Microbiol. 2020 Apr;18(4):211-226. doi: 10.1038/s41579-020-0324-0. PMID: 32071440; PMCID: PMC7942789.
Publisher Correction: In vivo structure of the Legionella type II secretion system by electron cryotomography. Ghosal D, Kim KW, Zheng H, Kaplan M, Truchan HK, Lopez AE, McIntire IE, Vogel JP, Cianciotto NP, Jensen GJ. Nat Microbiol. 2020 Apr;5(4):651. doi: 10.1038/s41564-020-0693-1. Erratum for: Nat Microbiol. 2019 Dec;4(12):2101-2108. PMID: 32076134.
5 challenges in understanding the role of the virome in health and disease. Wang D. PLoS Pathog. 2020 Mar 26;16(3):e1008318. doi: 10.1371/journal.ppat.1008318. PMID: 32214384; PMCID: PMC7098563.
Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis. Zhang T, Yin C, Boyd DF, Quarato G, Ingram JP, Shubina M, Ragan KB, Ishizuka T, Crawford JC, Tummers B, Rodriguez DA, Xue J, Peri S, Kaiser WJ, López CB, Xu Y, Upton JW, Thomas PG, Green DR, Balachandran S. Cell. 2020 Mar 19;180(6):1115-1129.e13. doi: 10.1016/j.cell.2020.02.050. PMID: 32200799; PMCID: PMC7153753.
Defining Stage-Specific Activity of Potent New Inhibitors of Cryptosporidium parvum Growth In Vitro. Funkhouser-Jones LJ, Ravindran S, Sibley LD. mBio. 2020 Mar 3;11(2):e00052-20. doi: 10.1128/mBio.00052-20. PMID: 32127445; PMCID: PMC7064746.
Distinct Chronic Post-Viral Lung Diseases upon Infection with Influenza or Parainfluenza Viruses Differentially Impact Superinfection Outcome. Garcia GL, Valenzuela A, Manzoni T, Vaughan AE, López CB. Am J Pathol. 2020 Mar;190(3):543-553. doi: 10.1016/j.ajpath.2019.11.003. PMID: 31866346; PMCID: PMC7073775.
Cryptococcus neoformans Chitin Synthase 3 Plays a Critical Role in Dampening Host Inflammatory Responses. Hole CR, Lam WC, Upadhya R, Lodge JK. mBio. 2020 Feb 18;11(1):e03373-19. doi: 10.1128/mBio.03373-19. PMID: 32071275; PMCID: PMC7029146.
Deposition of Host Matrix Proteins on Breast Implant Surfaces Facilitates Staphylococcus Epidermidis Biofilm Formation: In Vitro Analysis. Walker JN, Pinkner CL, Lynch AJL, Ortbal S, Pinkner JS, Hultgren SJ, Myckatyn TM. Aesthet Surg J. 2020 Feb 17;40(3):281-295. doi: 10.1093/asj/sjz099. PMID: 30953053.
Melanin deposition in two Cryptococcus species depends on cell-wall composition and flexibility Chrissian C, Camacho E, Fu MS, Prados-Rosales R, Chatterjee S, Cordero RJB, Lodge JK, Casadevall A, Stark RE.. J Biol Chem. 2020 Feb 14;295(7):1815-1828. doi: 10.1074/jbc.RA119.011949. PMID: 31896575; PMCID: PMC7029119.
Encephalitic Alphaviruses Exploit Caveola-Mediated Transcytosis at the Blood-Brain Barrier for Central Nervous System Entry.Salimi H, Cain MD, Jiang X, Roth RA, Beatty WL, Sun C, Klimstra WB, Hou J, Klein RS. mBio. 2020 Feb 11;11(1):e02731-19. doi: 10.1128/mBio.02731-19. PMID: 32047126; PMCID: PMC7018649.
A broad-spectrum antiviral molecule, QL47, selectively inhibits eukaryotic translation. de Wispelaere M, Carocci M, Burri DJ, Neidermyer WJ Jr, Olson CM, Roggenbach I, Liang Y, Wang J, Whelan SPJ, Gray NS, Yang PL. J Biol Chem. 2020 Feb 7;295(6):1694-1703. doi: 10.1074/jbc.RA119.011132. PMID: 31914414; PMCID: PMC7008383.
Nucleic Acid-Based Screening of Maternal Serum to Detect Viruses in Women with Labor or PROM. Shah AA, Wang D, Hirsch E. Reprod Sci. 2020 Feb;27(2):537-544. doi: 10.1007/s43032-019-00051-2. Epub 2020 Jan 10. PMID: 31925769.
Antiviral activity of ribavirin and favipiravir against human astroviruses. Janowski AB, Dudley H, Wang D. J Clin Virol. 2020 Feb;123:104247. doi: 10.1016/j.jcv.2019.104247. PMID: 31864069; PMCID: PMC7034780.
Immune correlates of tuberculosis disease and risk translate across species. Ahmed M, Thirunavukkarasu S, Rosa BA, Thomas KA, Das S, Rangel-Moreno J, Lu L, Mehra S, Mbandi SK, Thackray LB, Diamond MS, Murphy KM, Means T, Martin J, Kaushal D, Scriba TJ, Mitreva M, Khader SA. Sci Transl Med. 2020 Jan 29;12(528):eaay0233. doi: 10.1126/scitranslmed.aay0233. PMID: 31996462; PMCID: PMC7354419.
Anellovirus Dynamics Are Associated With Primary Graft Dysfunction in Lung Transplantation. Blatter JA, Takahashi T, Mittler B, Nava RG, Puri V, Kreisel D, Wang D. Transplant Direct. 2020 Jan 13;6(2):e521. doi: 10.1097/TXD.0000000000000969. PMID: 32095507; PMCID: PMC7004632.
Structure of the Vesicular Stomatitis Virus L Protein in Complex with Its Phosphoprotein Cofactor. Jenni S, Bloyet LM, Diaz-Avalos R, Liang B, Whelan SPJ, Grigorieff N, Harrison SC. Cell Rep. 2020 Jan 7;30(1):53-60.e5. doi: 10.1016/j.celrep.2019.12.024. PMID: 31914397; PMCID: PMC7049099.
5-fluorocytosine resistance is associated with hypermutation and alterations in capsule biosynthesis in Cryptococcus. Billmyre RB, Applen Clancey S, Li LX, Doering TL, Heitman J. Nat Commun. 2020 Jan 8;11(1):127. doi: 10.1038/s41467-019-13890-z. PMID: 31913284; PMCID: PMC6949227.
The Caenorhabditis elegans RIG-I Homolog DRH-1 Mediates the Intracellular Pathogen Response upon Viral Infection. Sowa JN, Jiang H, Somasundaram L, Tecle E, Xu G, Wang D, Troemel ER. J Virol. 2020 Jan 6;94(2):e01173-19. doi: 10.1128/JVI.01173-19. PMID: 31619561; PMCID: PMC6955