Recent publications
The intrinsically disordered protein TgIST from Toxoplasma gondii inhibits STAT1 signaling by blocking cofactor recruitment
Zhou Huang, Hejun Liu, Jay Nix, Rui Xu, Catherine R. Knoverek, Gregory R. Bowman, Gaya K. Amarasinghe & L. David Sibley
Nature 13 July 2022
Re-Examining Rotavirus Innate Immune Evasion: Potential Applications of the Reverse Genetics System
Avan Antia, Amanda N Pinski, Siyuan Ding
PMID: 35699371 DOI: 10.1128/mbio.01308-22
MBio 14 June 2022
Evolutionarily stable gene clusters shed light on the common grounds of pathogenicity in the Acinetobacter calcoaceticus-baumannii complex
Bardya Djahanschiri 1, Gisela Di Venanzio 2, Jesus S Distel 2, Jennifer Breisch 3, Marius Alfred Dieckmann 4, Alexander Goesmann 4, Beate Averhoff 3, Stephan Göttig 5, Gottfried Wilharm 6, Mario F Feldman 2, Ingo Ebersberger 1 7 8
PMID: 35653398 PMCID: PMC9162365 DOI: 10.1371/journal.pgen.1010020
MBio 2 June 2022
InvL, an Invasin-Like Adhesin, Is a Type II Secretion System Substrate Required for Acinetobacter baumannii Uropathogenesis
Clay D Jackson-Litteken # 1, Gisela Di Venanzio # 1, Nguyen-Hung Le 1, Nichollas E Scott 2, Bardya Djahanschiri 3, Jesus S Distel 1, Evan J Pardue 1, Ingo Ebersberger 3 4 5, Mario F Feldman 1
PMID: 35638734 DOI: 10.1128/mbio.00258-22
MBio 31 May 2022
The Phenylacetic Acid Catabolic Pathway Regulates Antibiotic and Oxidative Stress Responses in Acinetobacter
Anna J Hooppaw 1, Jenna C McGuffey 1, Gisela Di Venanzio 1, Juan C Ortiz-Marquez 2, Brent S Weber 1, Tasia Joy Lightly 3, Tim van Opijnen 2, Nichollas E Scott 4, Silvia T Cardona 3, Mario F Feldman 1
PMID: 35467424 DOI: 10.1128/mbio.01863-21
MBio 25 April 2022
Defining the risk of SARS-CoV-2 variants on immune protection
Marciela M DeGrace # 1 2, Elodie Ghedin # 1 3, Matthew B Frieman # 4, Florian Krammer # 5 6, Alba Grifoni # 7, Arghavan Alisoltani 8, Galit Alter 9, Rama R Amara 10, Ralph S Baric 11 12, Dan H Barouch 13, Jesse D Bloom 14, Louis-Marie Bloyet 15, Gaston Bonenfant 16, Adrianus C M Boon 17, Eli A Boritz 1 2 18, Debbie L Bratt 1 2 19, Traci L Bricker 17, Liliana Brown 1 2, William J Buchser 20, Juan Manuel Carreño 21, Liel Cohen-Lavi 22, Tamarand L Darling 17, Meredith E Davis-Gardner 23, Bethany L Dearlove 24, Han Di 16, Meike Dittmann 25, Nicole A Doria-Rose 1 18, Daniel C Douek 1 18, Christian Drosten 26, Venkata-Viswanadh Edara 23, Ali Ellebedy 27, Thomas P Fabrizio 28, Guido Ferrari 29, William C Florence 1 2, Ron A M Fouchier 30, John Franks 28, Adolfo García-Sastre 21 31 32 33 34, Adam Godzik 8, Ana Silvia Gonzalez-Reiche 35, Aubree Gordon 36, Bart L Haagmans 30, Peter J Halfmann 37, David D Ho 38, Michael R Holbrook 39, Yaoxing Huang 38, Sarah L James 40, Lukasz Jaroszewski 8, Trushar Jeevan 28, Robert M Johnson 4, Terry C Jones 26 40, Astha Joshi 17, Yoshihiro Kawaoka 37 41 42, Lisa Kercher 43, Marion P G Koopmans 30, Bette Korber 44, Eilay Koren 22 45, Richard A Koup 1 18, Eric B LeGresley 40, Jacob E Lemieux 46, Mariel J Liebeskind 20, Zhuoming Liu 15, Brandi Livingston 43, James P Logue 4, Yang Luo 38, Adrian B McDermott 1 18, Margaret J McElrath 47, Victoria A Meliopoulos 43, Vineet D Menachery 48, David C Montefiori 49, Barbara Mühlemann 26 40, Vincent J Munster 50, Jenny E Munt 11, Manoj S Nair 38, Antonia Netzl 40, Anna M Niewiadomska 51, Sijy O’Dell 1 18, Andrew Pekosz 52, Stanley Perlman 53, Marjorie C Pontelli 15, Barry Rockx 30, Morgane Rolland 24, Paul W Rothlauf 15, Sinai Sacharen 22 45, Richard H Scheuermann 51, Stephen D Schmidt 1 18, Michael Schotsaert 21 34, Stacey Schultz-Cherry 43, Robert A Seder 1 18, Mayya Sedova 8, Alessandro Sette 7 54, Reed S Shabman 1 2, Xiaoying Shen 29, Pei-Yong Shi 55, Maulik Shukla 56 57, Viviana Simon 21 31 32 34, Spencer Stumpf 15, Nancy J Sullivan 1 18, Larissa B Thackray 58, James Theiler 44, Paul G Thomas 59, Sanja Trifkovic 28, Sina Türeli 40, Samuel A Turner 40, Maria A Vakaki 20, Harm van Bakel 35, Laura A VanBlargan 58, Leah R Vincent 1 2, Zachary S Wallace 60 61, Li Wang 16, Maple Wang 38, Pengfei Wang 38, Wei Wang 62, Scott C Weaver 48, Richard J Webby 28, Carol D Weiss 62, David E Wentworth 16, Stuart M Weston 4, Sean P J Whelan 15, Bradley M Whitener 58, Samuel H Wilks 40, Xuping Xie 55, Baoling Ying 58, Hyejin Yoon 44, Bin Zhou 16, Tomer Hertz 63, Derek J Smith 64, Michael S Diamond 65, Diane J Post 66 67, Mehul S Suthar 68
PMID: 35361968 DOI: 10.1038/s41586-022-04690-5
Nature 31 March 2022
StrainGE: a toolkit to track and characterize low-abundance strains in complex microbial communities
Lucas R van Dijk # 1 2, Bruce J Walker # 1 3, Timothy J Straub 1 4, Colin J Worby 1, Alexandra Grote 1, Henry L Schreiber 4th 5 6, Christine Anyansi 2, Amy J Pickering 7 8, Scott J Hultgren 5 6, Abigail L Manson 1, Thomas Abeel 1 2, Ashlee M Earl 9
PMID: 35255937 PMCID: PMC8900328 DOI: 10.1186/s13059-022-02630-0
Genome Biology 7 March 2022
CD164 is a host factor for lymphocytic choriomeningitis virus entry
Mark J G Bakkers 1, Alex Moon-Walker 1 2 3 4, Rasmus Herlo 5, Vesna Brusic 1, Sarah Hulsey Stubbs 1, Kathryn M Hastie 3, Erica Ollmann Saphire 3, Tomas L Kirchhausen 5 6, Sean P J Whelan 1 4
PMID: 35235462 PMCID: PMC8915965 DOI: 10.1073/pnas.2119676119
PNAS 2 March 2022
Establishing the role of the gut microbiota in susceptibility to recurrent urinary tract infections
Colin J Worby 1, Benjamin S Olson 2 3, Karen W Dodson 2 3, Ashlee M Earl 1, Scott J Hultgren 2 3
PMID: 35229729 PMCID: PMC8884912 DOI: 10.1172/JCI158497
JCL 1 March 2022
Rifampin resistance mutations in the rpoB gene of Enterococcus faecalis impact host macrophage cytokine production
Darya V Urusova 1, Joseph A Merriman 1, Ananya Gupta 1, Liang Chen 2, Barun Mathema 3, Michael G Caparon 1, Shabaana A Khader 4
PMID: 35030469 DOI: 10.1016/j.cyto.2021.155788
Cytokine March 2022
Epigenetic Modifiers Alter Host Cell Transcription to Promote Toxoplasma Infection
Alex Rosenberg 1, L David Sibley 1
PMID: 35201740 DOI: 10.1021/acsinfecdis.2c00054
ACS 24 February 2022
Myeloid cell interferon responses correlate with clearance of SARS-CoV-2
Dhiraj K Singh # 1, Ekaterina Aladyeva # 2, Shibali Das # 3, Bindu Singh 1, Ekaterina Esaulova 2, Amanda Swain 2, Mushtaq Ahmed 3, Journey Cole 1, Chivonne Moodley 1 4, Smriti Mehra 1, Larry S Schlesinger 1, Maxim N Artyomov 5, Shabaana A Khader 6, Deepak Kaushal 7
PMID: 35115549 PMCID: PMC8814034 DOI: 10.1038/s41467-022-28315-7
Nature Communications 23 February 2022
Lipidomics Analysis of Outer Membrane Vesicles and Elucidation of the Inositol Phosphoceramide Biosynthetic Pathway in Bacteroides thetaiotaomicron
Mariana G Sartorio # 1, Ezequiel Valguarnera # 1, Fong-Fu Hsu 2, Mario F Feldman 1
PMID: 35080445 PMCID: PMC8791184 DOI: 10.1128/spectrum.00634-21
Bacteriology 23 February 2022
Molecular dissection of RbpA-mediated regulation of fidaxomicin sensitivity in mycobacteria
Jerome Prusa 1, Dennis X Zhu 1, Aidan J Flynn 1, Drake Jensen 2, Ana Ruiz Manzano 2, Eric A Galburt 2, Christina L Stallings 3
PMID: 35189142 PMCID: PMC8956947 DOI: 10.1016/j.jbc.2022.101752
JBC 19 February 2022
Germinal centre-driven maturation of B cell response to mRNA vaccination
Wooseob Kim # 1, Julian Q Zhou # 1, Stephen C Horvath 1, Aaron J Schmitz 1, Alexandria J Sturtz 1, Tingting Lei 1, Zhuoming Liu 2, Elizaveta Kalaidina 3, Mahima Thapa 1, Wafaa B Alsoussi 1, Alem Haile 4, Michael K Klebert 4, Teresa Suessen 5, Luis Parra-Rodriguez 6, Philip A Mudd 7 8, Sean P J Whelan 2, William D Middleton 5, Sharlene A Teefey 5, Iskra Pusic 9, Jane A O’Halloran 6, Rachel M Presti 6 8, Jackson S Turner 1, Ali H Ellebedy 10 11 12
PMID: 35168246 DOI: 10.1038/s41586-022-04527-1
Nature 15 February 2022
m6A modifications regulate intestinal immunity and rotavirus infection
Anmin Wang 1 2, Wanyiin Tao 1 2, Jiyu Tong 3, Juanzi Gao 1, Jinghao Wang 1, Gaopeng Hou 4, Chen Qian 1, Guorong Zhang 1 2, Runzhi Li 1 2, Decai Wang 1 2, Xingxing Ren 1 2, Kaiguang Zhang 1, Siyuan Ding 4, Richard A Flavell 5 6, Huabing Li 3, Wen Pan 1 2, Shu Zhu 1 2 7 8
PMID: 35098923 PMCID: PMC8860440 DOI: 10.7554/eLife.73628
Elife 31 January 2022
Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry
Young-Jun Park # 1 2, Anna De Marco # 3, Tyler N Starr # 4, Zhuoming Liu # 5, Dora Pinto 3, Alexandra C Walls 1 2, Fabrizia Zatta 3, Samantha K Zepeda 1, John E Bowen 1, Kaitlin R Sprouse 1, Anshu Joshi 1, Martina Giurdanella 3, Barbara Guarino 3, Julia Noack 6, Rana Abdelnabi 7, Shi-Yan Caroline Foo 7, Laura E Rosen 6, Florian A Lempp 6, Fabio Benigni 3, Gyorgy Snell 6, Johan Neyts 7, Sean P J Whelan 5, Herbert W Virgin 6 8 9, Jesse D Bloom 2 4, Davide Corti 3, Matteo Samuele Pizzuto 3, David Veesler 1 2
PMID: 34990214 DOI: 10.1126/science.abm8143
Science 28 January 2022
Longitudinal Study after Sputnik V Vaccination Shows Durable SARS-CoV-2 Neutralizing Antibodies and Reduced Viral Variant Escape to Neutralization over Time
María M Gonzalez Lopez Ledesma # 1, Lautaro Sanchez # 1, Diego S Ojeda # 1, Santiago Oviedo Rouco # 1, Andrés H Rossi 1, Augusto Varese 2, Ignacio Mazzitelli 2, Carla A Pascuale 1, Esteban A Miglietta 1, Pamela E Rodríguez 1, Horacio M Pallarés 1, Guadalupe S Costa Navarro 1, Julio J Caramelo 1, Paul W Rothlauf 3, Zhuoming Liu 3, Louis-Marie Bloyet 3, Marjorie Cornejo Pontelli 3, Natali B Rasetto 1, Shirley D Wenker 1, Lila Y Ramis 1, Magalí G Bialer 1, María Jose de Leone 1, C Esteban Hernando 1, Luciana Bianchimano 1, Antonella S Ríos 1, María Soledad Treffinger Cienfuegos 1, Diana R Rodriguez García 1, Yesica Longueira 2 4, Natalia Laufer 2 4, Diego Alvarez 5, Ana Ceballos 2, Valeria Ochoa 2, Cecilia Monzani 2, Gariela Turk 2 4, Melina Salvatori 2, Jorge Carradori 6, Katherine Prost 7, Alejandra Rima 8, Claudia Varela 9, Regina Ercole 10, Rosana I Toro 11, Sebastian Gutierrez 12, Martín Zubieta 13, Dolores Acuña 14, Mercedes S Nabaes Jodar 14, Carolina Torres 14, Laura Mojsiejczuk 14, Mariana Viegas 14, Pilar Velazquez 15, Clarisa Testa 15, Nicolas Kreplak 15, Marcelo Yanovsky 1, Sean Whelan 3, Jorge Geffner 2, Marina Pifano 15, Andrea V Gamarnik 1
PMID: 35073758 PMCID: PMC8787469 DOI: 10.1128/mbio.03442-21
mBio 25 January 2022
Bicyclic azetidines target acute and chronic stages of Toxoplasma gondii by inhibiting parasite phenylalanyl t-RNA synthetase
Joshua B Radke 1, Bruno Melillo 2 3, Payal Mittal 4 5, Manmohan Sharma 4, Amit Sharma 4 5, Yong Fu 1, Taher Uddin 1, Arthur Gonse 3, Eamon Comer 3, Stuart L Schreiber 3 6, Anil K Gupta 2 7, Arnab K Chatterjee 2 7, L David Sibley 8
PMID: 35075105 PMCID: PMC8786932 DOI: 10.1038/s41467-022-28108-y
Nature Communications 24 January 2022
The immunoregulatory landscape of human tuberculosis granulomas
Erin F McCaffrey 1, Michele Donato 2 3, Leeat Keren 4, Zhenghao Chen 5, Alea Delmastro 1, Megan B Fitzpatrick 6, Sanjana Gupta 2 3, Noah F Greenwald 1, Alex Baranski 1, William Graf 7, Rashmi Kumar 1, Marc Bosse 1, Christine Camacho Fullaway 1, Pratista K Ramdial 8, Erna Forgó 1, Vladimir Jojic 5, David Van Valen 7, Smriti Mehra 9, Shabaana A Khader 10, Sean C Bendall 1, Matt van de Rijn 1, Daniel Kalman 11, Deepak Kaushal 12, Robert L Hunter 13, Niaz Banaei 1 14, Adrie J C Steyn 8 15, Purvesh Khatri 2 3, Michael Angelo 16
PMID: 35058616 PMCID: PMC8810384 DOI: 10.1038/s41590-021-01121-x
Nature Immunology 20 January 2022
JIB-04 Has Broad-Spectrum Antiviral Activity and Inhibits SARS-CoV-2 Replication and Coronavirus Pathogenesis
Juhee Son # 1 2, Shimeng Huang # 3, Qiru Zeng # 1, Traci L Bricker 4, James Brett Case 4, Jinzhu Zhou 3, Ruochen Zang 1 5, Zhuoming Liu 1, Xinjian Chang 3, Tamarand L Darling 4, Jian Xu 6, Houda H Harastani 4, Lu Chen 7, Maria Florencia Gomez Castro 1, Yongxiang Zhao 3, Hinissan P Kohio 1, Gaopeng Hou 1, Baochao Fan 3, Beibei Niu 3, Rongli Guo 3, Paul W Rothlauf 1 8, Adam L Bailey 9, Xin Wang 5, Pei-Yong Shi 10, Elisabeth D Martinez 11, Steven L Brody 6, Sean P J Whelan 1, Michael S Diamond 1 4 9, Adrianus C M Boon 1 4 9, Bin Li 3, Siyuan Ding 1
PMID: 35038906 PMCID: PMC8764536 DOI: 10.1128/mbio.03377-21
mBio 18 January 2022
Targeting the Fusion Process of SARS-CoV-2 Infection by Small Molecule Inhibitors
Seung Bum Park 1, Parker Irvin 1, Zongyi Hu 1, Mohsin Khan 1, Xin Hu 2, Qiru Zeng 3, Catherine Chen 2, Miao Xu 2, Madeleine Leek 1, Ruochen Zang 3, James Brett Case 4, Wei Zheng 2, Siyuan Ding 3, T Jake Liang 1
PMID: 35012356 PMCID: PMC8749431 DOI: 10.1128/mbio.03238-21
mBio 11 January 2022
SARS-CoV-2 spreads through cell-to-cell transmission
Cong Zeng 1 2, John P Evans 1 2 3, Tiffany King 4 5, Yi-Min Zheng 1 2, Eugene M Oltz 6, Sean P J Whelan 7, Linda J Saif 8 9 10, Mark E Peeples 4 5 10, Shan-Lu Liu 11 2 6 10
PMID: 34937699 PMCID: PMC8740724 DOI: 10.1073/pnas.2111400119
PNAS 22 December 2021
Longitudinal Dynamics of a Blood Transcriptomic Signature of Tuberculosis
Humphrey Mulenga 1, Munyaradzi Musvosvi 1, Simon C Mendelsohn 1, Adam Penn-Nicholson 1, Stanley Kimbung Mbandi 1, Andrew Fiore-Gartland 2, Michèle Tameris 1, Simbarashe Mabwe 1, Hadn Africa 1, Nicole Bilek 1, Fazlin Kafaar 1, Shabaana A Khader 3, Balie Carstens 1, Katie Hadley 1, Chris Hikuam 1, Mzwandile Erasmus 1, Lungisa Jaxa 1, Rodney Raphela 1, Onke Nombida 1, Masooda Kaskar 1, Mark P Nicol 4 5, Slindile Mbhele 4, Judi Van Heerden 4, Craig Innes 6, William Brumskine 6, Andriëtte Hiemstra 7, Stephanus T Malherbe 7, Razia Hassan-Moosa 8 9, Gerhard Walzl 7, Kogieleum Naidoo 8 9, Gavin Churchyard 6 10, Mark Hatherill 1, Thomas J Scriba 1, CORTIS Study Team
PMID: 34520313 PMCID: PMC8865716 DOI: 10.1164/rccm.202103-0548OC
ATS Journals 15 December 2021
Myeloid-Derived Suppressor Cells Mediate T Cell Dysfunction in Nonhuman Primate TB Granulomas
Bindu Singh # 1, Dhiraj K Singh # 1, Shashank R Ganatra 1, Ruby A Escobedo 1, Shabaana Khader 2, Larry S Schlesinger 1, Deepak Kaushal 1, Smriti Mehra 1
PMID: 34903057 DOI: 10.1128/mbio.03189-21
mBio 14 December 2021
Rotavirus NSP1 Contributes to Intestinal Viral Replication, Pathogenesis, and Transmission
Gaopeng Hou 1, Qiru Zeng 1, Jelle Matthijnssens 2, Harry B Greenberg 3 4 5, Siyuan Ding 1
PMID: 34903043 DOI: 10.1128/mBio.03208-21
mBio 14 December 2021
Over-expression screen of interferon-stimulated genes identifies RARRES3 as a restrictor of Toxoplasma gondii infection
Nicholas Rinkenberger 1, Michael E Abrams 2, Sumit K Matta 1, John W Schoggins 2, Neal M Alto 3, L David Sibley 1
PMID: 34871166 DOI: 10.7554/eLife.73137
Elife 6 December 2021
Adding Fuel to The Fire? A Role of Intraepithelial Lymphocytes in Enteric Immune Responses to SARS-CoV-2 Infection
Avan Antia 1, David M Alvarado 2, Siyuan Ding 1, Matthew A Ciorba 2
PMID: 34864073 DOI: 10.1053/j.gastro.2021.12.001
Gastroenterology 2 December 2021
Toxoplasma bradyzoites exhibit physiological plasticity of calcium and energy stores controlling motility and egress
Yong Fu 1, Kevin M Brown 1, Nathaniel G Jones 1, Silvia Nj Moreno 2, L David Sibley 1
PMID: 34860156 DOI: 10.7554/eLife.73011
Elife 3 December 2021
Antiretroviral therapy timing impacts latent tuberculosis infection reactivation in a tuberculosis/simian immunodeficiency virus coinfection model
Riti Sharan 1, Shashank R Ganatra 1, Allison N Bucsan 2, Journey Cole 1, Dhiraj K Singh 1, Xavier Alvarez 1, Maya Gough 1, Cynthia Alvarez 1, Alyssa Blakley 1, Justin Ferdin 1, Rajesh Thippeshappa 1, Bindu Singh 1, Ruby Escobedo 1, Vinay Shivanna 1, Edward J Dick Jr 1, Shannan Hall-Ursone 1, Shabaana A Khader 2, Smriti Mehra 3, Jyothi Rengarajan 4, Deepak Kaushal 1
PMID: 34855621 DOI: 10.1172/JCI153090
J Clin Invest 2 December 2021
Mesalamine Reduces Intestinal ACE2 Expression Without Modifying SARS-CoV-2 Infection or Disease Severity in Mice
David M Alvarado 1, Juhee Son 2, Larissa B Thackray 3, Maria Florencia Gomez Castro 2, Sarada Prasad 1, Xueyang Cui 1 4, Naomi M Sonnek 1, Michael S Diamond 2 3 5, Siyuan Ding 2, Matthew A Ciorba 1
PMID: 34849936 DOI: 10.1093/ibd/izab274
Inflamm Bowel Dis. 28 November 2021
Amilorides inhibit SARS-CoV-2 replication in vitro by targeting RNA structures
Martina Zafferani 1, Christina Haddad 2, Le Luo 2, Jesse Davila-Calderon 2, Liang-Yuan Chiu 2, Christian Shema Mugisha 3, Adeline G Monaghan 1, Andrew A Kennedy 4, Joseph D Yesselman 5, Robert J Gifford 6, Andrew W Tai 4, Sebla B Kutluay 3, Mei-Ling Li 7, Gary Brewer 7, Blanton S Tolbert 2, Amanda E Hargrove 1
PMID: 34826236 DOI: 10.1126/sciadv.abl6096
Sci Adv. 26 November 2021
Inhibitor of growth protein 3 epigenetically silences endogenous retroviral elements and prevents innate immune activation
Yanhua Song, Gaopeng Hou, Jonathan Diep, Yaw Shin Ooi, Natalia S Akopyants, Stephen M Beverley, Jan E Carette, Harry B Greenberg, Siyuan Ding
PMID: 34791430 DOI: 10.1093/nar/gkab1070
Nucleic Acids Research 17 November 2021
Development and Immunogenicity of a Prototype Multivalent Group B Streptococcus Bioconjugate Vaccine
Jeremy A Duke , Amy V Paschall , Lloyd S Robinson , Cory J Knoot , Evgeny Vinogradov , Nichollas E Scott , Mario F Feldman , Fikri Y Avci , Christian M Harding
PMID: 34633812 DOI: 10.1021/acsinfecdis.1c00415
ACS Infect. Dis 12 November 2021
Commensal Cryptosporidium colonization elicits a cDC1-dependent Th1 response that promotes intestinal homeostasis and limits other infections
Emilie V Russler-Germain , Jisun Jung , Aidan T Miller , Shannon Young , Jaeu Yi , Alec Wehmeier , Lindsey E Fox , Kristen J Monte , Jiani N Chai , Devesha H Kulkarni , Lisa J Funkhouser-Jones , Georgia Wilke , Vivek Durai , Bernd H Zinselmeyer , Rafael S Czepielewski , Suellen Greco , Kenneth M Murphy , Rodney D Newberry , L David Sibley , Chyi-Song Hsieh
PMID: 34715017 DOI: 10.1016/j.immuni.2021.10.002
Immunity 9 November 2021
A class II MHC-targeted vaccine elicits immunity against SARS-CoV-2 and its variants
Novalia Pishesha , Thibault J Harmand , Paul W Rothlauf , Patrique Praest , Ryan K Alexander , Renate van den Doel , Mariel J Liebeskind , Maria A Vakaki , Nicholas McCaul , Charlotte Wijne , Elisha Verhaar , William Pinney 3rd , Hailey Heston , Louis-Marie Bloyet , Marjorie Cornejo Pontelli , Ma Xenia G Ilagan , Robert Jan Lebbink , William J Buchser , Emmanuel J H J Wiertz , Sean P J Whelan , Hidde L Ploegh
PMID: 34654739 DOI: 10.1073/pnas.2116147118
PNAS 2 November 2021
High Seropositivity Rate of Neutralizing Antibodies to Astrovirus VA1 in Human Populations
Andrew B Janowski , Macee C Owen , Holly Dudley , Tomás López , Rafaela Espinosa , Memory Elvin-Lewis , Alejandro Colichon , Carlos F Arias , Peter D Burbelo , David Wang
PMID: 34468168 DOI: 10.1128/mSphere.00484-21
ASM Journals mSphere 27 October 2021
Isolation of Reconstructed Functional Ribonucleoprotein Complexes of Machupo Virus
Jesse D Pyle , Sean P J Whelan
PMID: 34432522 DOI: 10.1128/JVI.01054-21
Journal of Virology 27 October 2021
Structural mechanism of SARS-CoV-2 neutralization by two murine antibodies targeting the RBD
John M Errico , Haiyan Zhao , Rita E Chen , Zhuoming Liu , James Brett Case , Meisheng Ma , Aaron J Schmitz , Michael J Rau , James A J Fitzpatrick , Pei-Yong Shi , Michael S Diamond , Sean P J Whelan , Ali H Ellebedy , Daved H Fremont
PMID: 34655519 DOI: 10.1016/j.celrep.2021.109881
A Cell Press journal 26 October 2021
A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells
Matthew Mahoney , Vishnu C Damalanka , Michael A Tartell , Dong Hee Chung , André Luiz Lourenço , Dustin Pwee , Anne E Mayer Bridwell , Markus Hoffmann , Jorine Voss , Partha Karmakar , Nurit P Azouz , Andrea M Klingler , Paul W Rothlauf , Cassandra E Thompson , Melody Lee , Lidija Klampfer , Christina L Stallings , Marc E Rothenberg , Stefan Pöhlmann , Sean P J Whelan , Anthony J O’Donoghue , Charles S Craik , James W Janetka
PMID: 34635581 DOI: 10.1073/pnas.2108728118
PNAS 26 October 2021
Neutralizing Monoclonal Antibodies That Target the Spike Receptor Binding Domain Confer Fc Receptor-Independent Protection against SARS-CoV-2 Infection in Syrian Hamsters
Wen Su , Sin Fun Sia , Aaron J Schmitz , Traci L Bricker , Tyler N Starr , Allison J Greaney , Jackson S Turner , Bassem M Mohammed , Zhuoming Liu , Ka Tim Choy , Tamarand L Darling , Astha Joshi , Ka Man Cheng , Alvina Y L Wong , Houda H Harastani , John M Nicholls , Sean P J Whelan , Jesse D Bloom , Hui-Ling Yen , Ali H Ellebedy , Adrianus C M Boon
PMID: 34517754PMCID: DOI: 10.1128/mBio.02395-21
ASM Journals mBio 26 October 2021
Short homology-directed repair using optimized Cas9 in the pathogen Cryptococcus neoformans enables rapid gene deletion and tagging
Manning Y Huang 1, Meenakshi B Joshi 1, Michael J Boucher 1, Sujin Lee 1, Liza C Loza 2, Elizabeth A Gaylord 2, Tamara L Doering 2, Hiten D Madhani 1 3
PMID: 34791226 PMCID: PMC8733451 (available on 2022-10-23) DOI: 10.1093/genetics/iyab180
Genetics 23 October 2021
S100A8/A9 in COVID-19 pathogenesis: Impact on clinical outcomes
Leah Mellett , Shabaana A Khader
PMID: 34728150 PMCID: PMC8520505 DOI: 10.1016/j.cytogfr.2021.10.004
Cytokine & Growth Factor Reviews 17 October 2021
Cryptococcus neoformans Cda1 and Cda2 coordinate deacetylation of chitin during infection to control fungal virulence
Rajendra Upadhya , Woei C Lam , Camaron R Hole , Danealle Parchment , Chrono K Lee , Charles A Specht , Stuart M Levitz , Jennifer K Lodge
PMID: 34712865 PMCID: PMC8529172 DOI: 10.1016/j.tcsw.2021.100066
The Cell Surface 15 October 2021
Lrp1 is a host entry factor for Rift Valley fever virus
Safder S Ganaie 1, Madeline M Schwarz 2, Cynthia M McMillen 2, David A Price 1, Annie X Feng 1, Joseph R Albe 3, Wenjie Wang 1, Shane Miersch 4, Anthony Orvedahl 5, Aidan R Cole 1, Monica F Sentmanat 6, Nawneet Mishra 1, Devin A Boyles 3, Zachary T Koenig 2, Michael R Kujawa 2, Matthew A Demers 3, Ryan M Hoehl 3, Austin B Moyle 7, Nicole D Wagner 7, Sarah H Stubbs 8, Lia Cardarelli 4, Joan Teyra 4, Anita McElroy 9, Michael L Gross 7, Sean P J Whelan 10, John Doench 11, Xiaoxia Cui 6, Tom J Brett 12, Sachdev S Sidhu 4, Herbert W Virgin 13, Takeshi Egawa 1, Daisy W Leung 14, Gaya K Amarasinghe 15, Amy L Hartman 16
PMID: 34559985 PMCID: PMC8786218 DOI: 10.1016/j.cell.2021.09.001
Cell 30 September 2021