Recent publications
Myeloid-Derived Suppressor Cells Mediate T Cell Dysfunction in Nonhuman Primate TB Granulomas
Bindu Singh # 1, Dhiraj K Singh # 1, Shashank R Ganatra 1, Ruby A Escobedo 1, Shabaana Khader 2, Larry S Schlesinger 1, Deepak Kaushal 1, Smriti Mehra 1
PMID: 34903057 DOI: 10.1128/mbio.03189-21
mBio 14 December 2021
Rotavirus NSP1 Contributes to Intestinal Viral Replication, Pathogenesis, and Transmission
Gaopeng Hou 1, Qiru Zeng 1, Jelle Matthijnssens 2, Harry B Greenberg 3 4 5, Siyuan Ding 1
PMID: 34903043 DOI: 10.1128/mBio.03208-21
mBio 14 December 2021
Over-expression screen of interferon-stimulated genes identifies RARRES3 as a restrictor of Toxoplasma gondii infection
Nicholas Rinkenberger 1, Michael E Abrams 2, Sumit K Matta 1, John W Schoggins 2, Neal M Alto 3, L David Sibley 1
PMID: 34871166 DOI: 10.7554/eLife.73137
Elife 6 December 2021
Adding Fuel to The Fire? A Role of Intraepithelial Lymphocytes in Enteric Immune Responses to SARS-CoV-2 Infection
Avan Antia 1, David M Alvarado 2, Siyuan Ding 1, Matthew A Ciorba 2
PMID: 34864073 DOI: 10.1053/j.gastro.2021.12.001
Gastroenterology 2 December 2021
Toxoplasma bradyzoites exhibit physiological plasticity of calcium and energy stores controlling motility and egress
Yong Fu 1, Kevin M Brown 1, Nathaniel G Jones 1, Silvia Nj Moreno 2, L David Sibley 1
PMID: 34860156 DOI: 10.7554/eLife.73011
Elife 3 December 2021
Antiretroviral therapy timing impacts latent tuberculosis infection reactivation in a tuberculosis/simian immunodeficiency virus coinfection model
Riti Sharan 1, Shashank R Ganatra 1, Allison N Bucsan 2, Journey Cole 1, Dhiraj K Singh 1, Xavier Alvarez 1, Maya Gough 1, Cynthia Alvarez 1, Alyssa Blakley 1, Justin Ferdin 1, Rajesh Thippeshappa 1, Bindu Singh 1, Ruby Escobedo 1, Vinay Shivanna 1, Edward J Dick Jr 1, Shannan Hall-Ursone 1, Shabaana A Khader 2, Smriti Mehra 3, Jyothi Rengarajan 4, Deepak Kaushal 1
PMID: 34855621 DOI: 10.1172/JCI153090
J Clin Invest 2 December 2021
Mesalamine Reduces Intestinal ACE2 Expression Without Modifying SARS-CoV-2 Infection or Disease Severity in Mice
David M Alvarado 1, Juhee Son 2, Larissa B Thackray 3, Maria Florencia Gomez Castro 2, Sarada Prasad 1, Xueyang Cui 1 4, Naomi M Sonnek 1, Michael S Diamond 2 3 5, Siyuan Ding 2, Matthew A Ciorba 1
PMID: 34849936 DOI: 10.1093/ibd/izab274
Inflamm Bowel Dis. 28 November 2021
Amilorides inhibit SARS-CoV-2 replication in vitro by targeting RNA structures
Martina Zafferani 1, Christina Haddad 2, Le Luo 2, Jesse Davila-Calderon 2, Liang-Yuan Chiu 2, Christian Shema Mugisha 3, Adeline G Monaghan 1, Andrew A Kennedy 4, Joseph D Yesselman 5, Robert J Gifford 6, Andrew W Tai 4, Sebla B Kutluay 3, Mei-Ling Li 7, Gary Brewer 7, Blanton S Tolbert 2, Amanda E Hargrove 1
PMID: 34826236 DOI: 10.1126/sciadv.abl6096
Sci Adv. 26 November 2021
Inhibitor of growth protein 3 epigenetically silences endogenous retroviral elements and prevents innate immune activation
Yanhua Song, Gaopeng Hou, Jonathan Diep, Yaw Shin Ooi, Natalia S Akopyants, Stephen M Beverley, Jan E Carette, Harry B Greenberg, Siyuan Ding
PMID: 34791430 DOI: 10.1093/nar/gkab1070
Nucleic Acids Research 17 November 2021
Development and Immunogenicity of a Prototype Multivalent Group B Streptococcus Bioconjugate Vaccine
Jeremy A Duke , Amy V Paschall , Lloyd S Robinson , Cory J Knoot , Evgeny Vinogradov , Nichollas E Scott , Mario F Feldman , Fikri Y Avci , Christian M Harding
PMID: 34633812 DOI: 10.1021/acsinfecdis.1c00415
ACS Infect. Dis 12 November 2021
Commensal Cryptosporidium colonization elicits a cDC1-dependent Th1 response that promotes intestinal homeostasis and limits other infections
Emilie V Russler-Germain , Jisun Jung , Aidan T Miller , Shannon Young , Jaeu Yi , Alec Wehmeier , Lindsey E Fox , Kristen J Monte , Jiani N Chai , Devesha H Kulkarni , Lisa J Funkhouser-Jones , Georgia Wilke , Vivek Durai , Bernd H Zinselmeyer , Rafael S Czepielewski , Suellen Greco , Kenneth M Murphy , Rodney D Newberry , L David Sibley , Chyi-Song Hsieh
PMID: 34715017 DOI: 10.1016/j.immuni.2021.10.002
Immunity 9 November 2021
A class II MHC-targeted vaccine elicits immunity against SARS-CoV-2 and its variants
Novalia Pishesha , Thibault J Harmand , Paul W Rothlauf , Patrique Praest , Ryan K Alexander , Renate van den Doel , Mariel J Liebeskind , Maria A Vakaki , Nicholas McCaul , Charlotte Wijne , Elisha Verhaar , William Pinney 3rd , Hailey Heston , Louis-Marie Bloyet , Marjorie Cornejo Pontelli , Ma Xenia G Ilagan , Robert Jan Lebbink , William J Buchser , Emmanuel J H J Wiertz , Sean P J Whelan , Hidde L Ploegh
PMID: 34654739 DOI: 10.1073/pnas.2116147118
PNAS 2 November 2021
High Seropositivity Rate of Neutralizing Antibodies to Astrovirus VA1 in Human Populations
Andrew B Janowski , Macee C Owen , Holly Dudley , Tomás López , Rafaela Espinosa , Memory Elvin-Lewis , Alejandro Colichon , Carlos F Arias , Peter D Burbelo , David Wang
PMID: 34468168 DOI: 10.1128/mSphere.00484-21
ASM Journals mSphere 27 October 2021
Isolation of Reconstructed Functional Ribonucleoprotein Complexes of Machupo Virus
Jesse D Pyle , Sean P J Whelan
PMID: 34432522 DOI: 10.1128/JVI.01054-21
Journal of Virology 27 October 2021
Structural mechanism of SARS-CoV-2 neutralization by two murine antibodies targeting the RBD
John M Errico , Haiyan Zhao , Rita E Chen , Zhuoming Liu , James Brett Case , Meisheng Ma , Aaron J Schmitz , Michael J Rau , James A J Fitzpatrick , Pei-Yong Shi , Michael S Diamond , Sean P J Whelan , Ali H Ellebedy , Daved H Fremont
PMID: 34655519 DOI: 10.1016/j.celrep.2021.109881
A Cell Press journal 26 October 2021
A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells
Matthew Mahoney , Vishnu C Damalanka , Michael A Tartell , Dong Hee Chung , André Luiz Lourenço , Dustin Pwee , Anne E Mayer Bridwell , Markus Hoffmann , Jorine Voss , Partha Karmakar , Nurit P Azouz , Andrea M Klingler , Paul W Rothlauf , Cassandra E Thompson , Melody Lee , Lidija Klampfer , Christina L Stallings , Marc E Rothenberg , Stefan Pöhlmann , Sean P J Whelan , Anthony J O’Donoghue , Charles S Craik , James W Janetka
PMID: 34635581 DOI: 10.1073/pnas.2108728118
PNAS 26 October 2021
Neutralizing Monoclonal Antibodies That Target the Spike Receptor Binding Domain Confer Fc Receptor-Independent Protection against SARS-CoV-2 Infection in Syrian Hamsters
Wen Su , Sin Fun Sia , Aaron J Schmitz , Traci L Bricker , Tyler N Starr , Allison J Greaney , Jackson S Turner , Bassem M Mohammed , Zhuoming Liu , Ka Tim Choy , Tamarand L Darling , Astha Joshi , Ka Man Cheng , Alvina Y L Wong , Houda H Harastani , John M Nicholls , Sean P J Whelan , Jesse D Bloom , Hui-Ling Yen , Ali H Ellebedy , Adrianus C M Boon
PMID: 34517754PMCID: DOI: 10.1128/mBio.02395-21
ASM Journals mBio 26 October 2021
S100A8/A9 in COVID-19 pathogenesis: Impact on clinical outcomes
Leah Mellett , Shabaana A Khader
PMID: 34728150 PMCID: PMC8520505 DOI: 10.1016/j.cytogfr.2021.10.004
Cytokine & Growth Factor Reviews 17 October 2021
Cryptococcus neoformans Cda1 and Cda2 coordinate deacetylation of chitin during infection to control fungal virulence
Rajendra Upadhya , Woei C Lam , Camaron R Hole , Danealle Parchment , Chrono K Lee , Charles A Specht , Stuart M Levitz , Jennifer K Lodge
PMID: 34712865 PMCID: PMC8529172 DOI: 10.1016/j.tcsw.2021.100066
The Cell Surface 15 October 2021