Recent publications

Expanded Proteomic Survey of the Human Parasite Leishmania major Focusing on Changes in Null Mutants of the Golgi GDP-Mannose/Fucose/Arabinopyranose Transporter LPG2 and of the Mitochondrial Fucosyltransferase FUT1

Use of Leishmania major parasites expressing a recombinant Trypanosoma cruzi antigen as live vaccines against Chagas disease

Autophagy is required in macrophages and dendritic cells to prevent early recruitment of neutrophils during Mycobacterium tuberculosis infection

Rachel L. Kinsella, Jacqueline M. Kimmey, Asya Smirnov, Reilly Woodson, Margaret R. Gaggioli, Sthefany M. Chavez, Darren Kreamalmeyer, Christina L. Stallings

Bio 4 November 2022

Quantitative single-cell analysis of Leishmania major amastigote differentiation demonstrates variably extended expression of the lipophosphoglycan (LPG) virulence factor in different host cell types

Michael A MandellWandy L BeattyStephen M Beverley 

PLoS Negl Trop Dis. 16 October 2022

Visualizing molecular interactions that determine assembly of a bullet-shaped vesicular stomatitis virus particle

Maturation and substrate processing topography of the Plasmodium falciparum invasion/egress protease plasmepsin X

Sumit MukherjeeSuong NguyenEashan Sharma & Daniel E. Goldberg

Nature Communications 04 August 2022

The intrinsically disordered protein TgIST from Toxoplasma gondii inhibits STAT1 signaling by blocking cofactor recruitment

Re-Examining Rotavirus Innate Immune Evasion: Potential Applications of the Reverse Genetics System

Avan Antia,  Amanda N PinskiSiyuan Ding 

PMID: 35699371 DOI: 10.1128/mbio.01308-22

MBio 14 June 2022

The Dengue Virus Nonstructural Protein 1 (NS1) Interacts with the Putative Epigenetic Regulator DIDO1 to Promote Flavivirus Replication in Mosquito Cells

Evolutionarily stable gene clusters shed light on the common grounds of pathogenicity in the Acinetobacter calcoaceticus-baumannii complex

InvL, an Invasin-Like Adhesin, Is a Type II Secretion System Substrate Required for Acinetobacter baumannii Uropathogenesis

Detection of Bourbon Virus-Specific Serum Neutralizing Antibodies in Human Serum in Missouri, USA

The Phenylacetic Acid Catabolic Pathway Regulates Antibiotic and Oxidative Stress Responses in Acinetobacter

Defining the risk of SARS-CoV-2 variants on immune protection

Marciela M DeGrace # 1 2Elodie Ghedin # 1 3Matthew B Frieman # 4Florian Krammer # 5 6Alba Grifoni # 7Arghavan Alisoltani 8Galit Alter 9Rama R Amara 10Ralph S Baric 11 12Dan H Barouch 13Jesse D Bloom 14Louis-Marie Bloyet 15Gaston Bonenfant 16Adrianus C M Boon 17Eli A Boritz 1 2 18Debbie L Bratt 1 2 19Traci L Bricker 17Liliana Brown 1 2William J Buchser 20Juan Manuel Carreño 21Liel Cohen-Lavi 22Tamarand L Darling 17Meredith E Davis-Gardner 23Bethany L Dearlove 24Han Di 16Meike Dittmann 25Nicole A Doria-Rose 1 18Daniel C Douek 1 18Christian Drosten 26Venkata-Viswanadh Edara 23Ali Ellebedy 27Thomas P Fabrizio 28Guido Ferrari 29William C Florence 1 2Ron A M Fouchier 30John Franks 28Adolfo García-Sastre 21 31 32 33 34Adam Godzik 8Ana Silvia Gonzalez-Reiche 35Aubree Gordon 36Bart L Haagmans 30Peter J Halfmann 37David D Ho 38Michael R Holbrook 39Yaoxing Huang 38Sarah L James 40Lukasz Jaroszewski 8Trushar Jeevan 28Robert M Johnson 4Terry C Jones 26 40Astha Joshi 17Yoshihiro Kawaoka 37 41 42Lisa Kercher 43Marion P G Koopmans 30Bette Korber 44Eilay Koren 22 45Richard A Koup 1 18Eric B LeGresley 40Jacob E Lemieux 46Mariel J Liebeskind 20Zhuoming Liu 15Brandi Livingston 43James P Logue 4Yang Luo 38Adrian B McDermott 1 18Margaret J McElrath 47Victoria A Meliopoulos 43Vineet D Menachery 48David C Montefiori 49Barbara Mühlemann 26 40Vincent J Munster 50Jenny E Munt 11Manoj S Nair 38Antonia Netzl 40Anna M Niewiadomska 51Sijy O’Dell 1 18Andrew Pekosz 52Stanley Perlman 53Marjorie C Pontelli 15Barry Rockx 30Morgane Rolland 24Paul W Rothlauf 15Sinai Sacharen 22 45Richard H Scheuermann 51Stephen D Schmidt 1 18Michael Schotsaert 21 34Stacey Schultz-Cherry 43Robert A Seder 1 18Mayya Sedova 8Alessandro Sette 7 54Reed S Shabman 1 2Xiaoying Shen 29Pei-Yong Shi 55Maulik Shukla 56 57Viviana Simon 21 31 32 34Spencer Stumpf 15Nancy J Sullivan 1 18Larissa B Thackray 58James Theiler 44Paul G Thomas 59Sanja Trifkovic 28Sina Türeli 40Samuel A Turner 40Maria A Vakaki 20Harm van Bakel 35Laura A VanBlargan 58Leah R Vincent 1 2Zachary S Wallace 60 61Li Wang 16Maple Wang 38Pengfei Wang 38Wei Wang 62Scott C Weaver 48Richard J Webby 28Carol D Weiss 62David E Wentworth 16Stuart M Weston 4Sean P J Whelan 15Bradley M Whitener 58Samuel H Wilks 40Xuping Xie 55Baoling Ying 58Hyejin Yoon 44Bin Zhou 16Tomer Hertz 63Derek J Smith 64Michael S Diamond 65Diane J Post 66 67Mehul S Suthar 68

PMID: 35361968 DOI: 10.1038/s41586-022-04690-5

Nature 31 March 2022

StrainGE: a toolkit to track and characterize low-abundance strains in complex microbial communities

CD164 is a host factor for lymphocytic choriomeningitis virus entry

Establishing the role of the gut microbiota in susceptibility to recurrent urinary tract infections

Colin J Worby 1Benjamin S Olson 2 3Karen W Dodson 2 3Ashlee M Earl 1Scott J Hultgren 2 3

PMID: 35229729 PMCID: PMC8884912 DOI: 10.1172/JCI158497

JCL 1 March 2022

Rifampin resistance mutations in the rpoB gene of Enterococcus faecalis impact host macrophage cytokine production

Epigenetic Modifiers Alter Host Cell Transcription to Promote Toxoplasma Infection

Alex Rosenberg 1L David Sibley 1

PMID: 35201740 DOI: 10.1021/acsinfecdis.2c00054

ACS 24 February 2022

Myeloid cell interferon responses correlate with clearance of SARS-CoV-2

Lipidomics Analysis of Outer Membrane Vesicles and Elucidation of the Inositol Phosphoceramide Biosynthetic Pathway in Bacteroides thetaiotaomicron

Mariana G Sartorio # 1Ezequiel Valguarnera # 1Fong-Fu Hsu 2Mario F Feldman 1

PMID: 35080445 PMCID: PMC8791184 DOI: 10.1128/spectrum.00634-21

Bacteriology 23 February 2022

Molecular dissection of RbpA-mediated regulation of fidaxomicin sensitivity in mycobacteria

m6A modifications regulate intestinal immunity and rotavirus infection

Longitudinal Study after Sputnik V Vaccination Shows Durable SARS-CoV-2 Neutralizing Antibodies and Reduced Viral Variant Escape to Neutralization over Time

Bicyclic azetidines target acute and chronic stages of Toxoplasma gondii by inhibiting parasite phenylalanyl t-RNA synthetase

JIB-04 Has Broad-Spectrum Antiviral Activity and Inhibits SARS-CoV-2 Replication and Coronavirus Pathogenesis

Targeting the Fusion Process of SARS-CoV-2 Infection by Small Molecule Inhibitors

SARS-CoV-2 spreads through cell-to-cell transmission

Cong Zeng 1 2John P Evans 1 2 3Tiffany King 4 5Yi-Min Zheng 1 2Eugene M Oltz 6Sean P J Whelan 7Linda J Saif 8 9 10Mark E Peeples 4 5 10Shan-Lu Liu 11 2 6 10

PMID: 34937699 PMCID: PMC8740724 DOI: 10.1073/pnas.2111400119

PNAS 22 December 2021

Myeloid-Derived Suppressor Cells Mediate T Cell Dysfunction in Nonhuman Primate TB Granulomas

Rotavirus NSP1 Contributes to Intestinal Viral Replication, Pathogenesis, and Transmission

Gaopeng Hou 1Qiru Zeng 1Jelle Matthijnssens 2Harry B Greenberg 3 4 5Siyuan Ding 1

PMID: 34903043 DOI: 10.1128/mBio.03208-21

mBio 14 December 2021

Over-expression screen of interferon-stimulated genes identifies RARRES3 as a restrictor of Toxoplasma gondii infection

Adding Fuel to The Fire? A Role of Intraepithelial Lymphocytes in Enteric Immune Responses to SARS-CoV-2 Infection

Avan Antia 1David M Alvarado 2Siyuan Ding 1Matthew A Ciorba 2

PMID: 34864073 DOI: 10.1053/j.gastro.2021.12.001

Gastroenterology 2 December 2021

Toxoplasma bradyzoites exhibit physiological plasticity of calcium and energy stores controlling motility and egress

Yong Fu 1Kevin M Brown 1Nathaniel G Jones 1Silvia Nj Moreno 2L David Sibley 1

PMID: 34860156 DOI: 10.7554/eLife.73011

Elife 3 December 2021

Antiretroviral therapy timing impacts latent tuberculosis infection reactivation in a tuberculosis/simian immunodeficiency virus coinfection model

Mesalamine Reduces Intestinal ACE2 Expression Without Modifying SARS-CoV-2 Infection or Disease Severity in Mice

Amilorides inhibit SARS-CoV-2 replication in vitro by targeting RNA structures

Inhibitor of growth protein 3 epigenetically silences endogenous retroviral elements and prevents innate immune activation

Development and Immunogenicity of a Prototype Multivalent Group B Streptococcus Bioconjugate Vaccine

Commensal Cryptosporidium colonization elicits a cDC1-dependent Th1 response that promotes intestinal homeostasis and limits other infections

High Seropositivity Rate of Neutralizing Antibodies to Astrovirus VA1 in Human Populations

Isolation of Reconstructed Functional Ribonucleoprotein Complexes of Machupo Virus

Jesse D Pyle Sean P J Whelan 

PMID: 34432522 DOI: 10.1128/JVI.01054-21

Journal of Virology 27 October 2021

Structural mechanism of SARS-CoV-2 neutralization by two murine antibodies targeting the RBD

A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells

Neutralizing Monoclonal Antibodies That Target the Spike Receptor Binding Domain Confer Fc Receptor-Independent Protection against SARS-CoV-2 Infection in Syrian Hamsters

Short homology-directed repair using optimized Cas9 in the pathogen Cryptococcus neoformans enables rapid gene deletion and tagging

Manning Y Huang 1Meenakshi B Joshi 1Michael J Boucher 1Sujin Lee 1Liza C Loza 2Elizabeth A Gaylord 2Tamara L Doering 2Hiten D Madhani 1 3

PMID: 34791226 PMCID: PMC8733451 (available on 2022-10-23) DOI: 10.1093/genetics/iyab180

Genetics 23 October 2021

S100A8/A9 in COVID-19 pathogenesis: Impact on clinical outcomes

Leah Mellett Shabaana A Khader 

PMID: 34728150 PMCID: PMC8520505 DOI: 10.1016/j.cytogfr.2021.10.004

Cytokine & Growth Factor Reviews 17 October 2021

Cryptococcus neoformans Cda1 and Cda2 coordinate deacetylation of chitin during infection to control fungal virulence