Publications

Recent publications

2024

Kimball, A., Funkhouser-Jones, L., Huang, W., Xu, R., Witola, W. H., & Sibley, L. D. (2024). Mendelian segregation and high recombination rates facilitate genetic analyses in Cryptosporidium parvum. PLoS genetics, 20(6), e1011162. Advance online publication. https://doi.org/10.1371/journal.pgen.1011162

Ence, C. C., Uddin, T., Borrel, J., Mittal, P., Xie, H., Zoller, J., Sharma, A., Comer, E., Schreiber, S. L., Melillo, B., Sibley, L. D., & Chatterjee, A. K. (2024). Bicyclic Pyrrolidine Inhibitors of Toxoplasma gondii Phenylalanine t-RNA Synthetase with Antiparasitic Potency In Vitro and Brain Exposure. ACS infectious diseases, 10(6), 2212–2221. https://doi.org/10.1021/acsinfecdis.4c00170

Shaw, A. B., Tse, H. N., Byford, O., Plahe, G., Moon-Walker, A., Hover, S. E., Saphire, E. O., Whelan, S. P. J., Mankouri, J., Fontana, J., & Barr, J. N. (2024). Cellular endosomal potassium ion flux regulates arenavirus uncoating during virus entry. mBio, e0168423. Advance online publication. https://doi.org/10.1128/mbio.01684-23

Armbruster, K. M., Jiang, J., Sartorio, M. G., Scott, N. E., Peterson, J. M., Sexton, J. Z., Feldman, M. F., & Koropatkin, N. M. (2024). Identification and Characterization of the Lipoprotein N-acyltransferase in Bacteroides. bioRxiv : the preprint server for biology, 2024.05.31.596883. https://doi.org/10.1101/2024.05.31.596883

Young, M. G., Straub, T. J., Worby, C. J., Metsky, H. C., Gnirke, A., Bronson, R. A., van Dijk, L. R., Desjardins, C. A., Matranga, C., Qu, J., Villicana, J. B., Azimzadeh, P., Kau, A., Dodson, K. W., Schreiber, H. L., 4th, Manson, A. L., Hultgren, S. J., & Earl, A. M. (2024). Distinct Escherichia coli transcriptional profiles in the guts of recurrent UTI sufferers revealed by pangenome hybrid selection. bioRxiv : the preprint server for biology, 2024.02.29.582780. https://doi.org/10.1101/2024.02.29.582780

Hendrix, S. V., Mreyoud, Y., McNehlan, M. E., Smirnov, A., Chavez, S. M., Hie, B., Chamberland, M. M., Bradstreet, T. R., Webber, A. M., Kreamalmeyer, D., Taneja, R., Bryson, B. D., Edelson, B. T., & Stallings, C. L. (2024). BHLHE40 Regulates Myeloid Cell Polarization through IL-10-Dependent and -Independent Mechanisms. Journal of immunology (Baltimore, Md. : 1950), 212(11), 1766–1781. https://doi.org/10.4049/jimmunol.2200819

Li, X., Yang, Y., & López, C. B. (2024). Indiscriminate activities of different henipavirus polymerase complex proteins allow for efficient minigenome replication in hybrid systems. Journal of virology, 98(6), e0050324. https://doi.org/10.1128/jvi.00503-24

Loza, L., & Doering, T. L. (2024). A fungal protein organizes both glycogen and cell wall glucans. Proceedings of the National Academy of Sciences of the United States of America, 121(21), e2319707121. https://doi.org/10.1073/pnas.2319707121

Bisaro, F., Jackson-Litteken, C. D., McGuffey, J. C., Hooppaw, A. J., Bodrog, S., Jebeli, L., Ortiz-Marquez, J. C., van Opijnen, T., Scott, N. E., Di Venanzio, G., & Feldman, M. F. (2024). Diclofenac sensitizes multi-drug resistant Acinetobacter baumannii to colistin. bioRxiv : the preprint server for biology, 2024.05.17.594771. https://doi.org/10.1101/2024.05.17.594771

Liang, C. Y., Raju, S., Liu, Z., Li, Y., Asthagiri Arunkumar, G., Case, J. B., Scheaffer, S. M., Zost, S. J., Acreman, C. M., Gagne, M., Andrew, S. F., Carvalho Dos Anjos, D. C., Foulds, K. E., McLellan, J. S., Crowe, J. E., Jr, Douek, D. C., Whelan, S. P. J., Elbashir, S. M., Edwards, D. K., & Diamond, M. S. (2024). Imprinting of serum neutralizing antibodies by Wuhan-1 mRNA vaccines. Nature, 10.1038/s41586-024-07539-1. Advance online publication. https://doi.org/10.1038/s41586-024-07539-1

Gaylord, E. A., Choy, H. L., Chen, G., Briner, S. L., & Doering, T. L. (2024). Sac1 links phosphoinositide turnover to cryptococcal virulence. bioRxiv : the preprint server for biology, 2024.01.18.576303. https://doi.org/10.1101/2024.01.18.576303

Eschbach, J. E., Puray-Chavez, M., Mohammed, S., Wang, Q., Xia, M., Huang, L.-C., Shan, L., & Kutluay, S. B. (2024). HIV-1 capsid stability and reverse transcription are finely balanced to minimize sensing of reverse transcription products via the cGAS-STING pathway. mBio, 15(5), e0034824. https://doi.org/10.1128/mbio.00348-24

Kang, Y. S., Jung, J., Brown, H., Mateusiak, C., Doering, T. L., & Brent, M. R. (2024). How host-like signals drive gene expression and capsule expansion in Cryptococcus neoformans. bioRxiv : the preprint server for biology, 2023.04.19.537239. https://doi.org/10.1101/2023.04.19.537239

Musa, A. O., Faber, S. R., Forrest, K., Smith, K. P., Sengupta, S., & López, C. B. (2024). Identification of distinct genotypes in circulating RSV A strains based on variants on the virus replication-associated genes. bioRxiv : the preprint server for biology, 2024.04.22.590570. https://doi.org/10.1101/2024.04.22.590570

Pinski, A. N., Gan, T., Lin, S.-C., Droit, L., Diamond, M., Barouch, D. H., & Wang, D. (2024). Isolation of a recombinant simian adenovirus encoding the human adenovirus G52 hexon suggests a simian origin for human adenovirus G52. Journal of virology, 98(4), e0004324. https://doi.org/10.1128/jvi.00043-24

Molina, J. J., Kohler, K. N., Gager, C., Andersen, M. J., Wongso, E., Lucas, E. R., Paik, A., Xu, W., Donahue, D. L., Bergeron, K., Klim, A., Caparon, M. G., Hultgren, S. J., Desai, A., Ploplis, V. A., Flick, M. J., Castellino, F. J., & Flores-Mireles, A. L. (2024). Fibrinolytic-deficiencies predispose hosts to septicemia from a catheter-associated UTI. Nature communications, 15(1), 2704. https://doi.org/10.1038/s41467-024-46974-6

Zeng, Q., Antia, A., Casorla-Perez, L. A., Puray-Chavez, M., Kutluay, S. B., Ciorba, M. A., & Ding, S. (2024). Calpain-2 mediates SARS-CoV-2 entry via regulating ACE2 levels. mBio, 15(3), e0228723. https://doi.org/10.1128/mbio.02287-23

Maddirala, A. R., Tamadonfar, K., Pinkner, J. S., Sanick, D., Hultgren, S. J., & Janetka, J. W. (2024). Discovery of Orally Bioavailable FmlH Lectin Antagonists as Treatment for Urinary Tract Infections. Journal of medicinal chemistry, 67(5), 3668–3678. https://doi.org/10.1021/acs.jmedchem.3c02128

Perer, E., Stacey, H., Eichorn, T., Hughey, H., Lawrence, J., Cunningham, E., Johnson, M. O., Bacon, K., Kau, A., Hultgren, S. J., Hooton, T. M., & Harris, J. L. (2024). Case report: Long-term follow-up of patients who received a FimCH vaccine for prevention of recurrent urinary tract infections caused by antibiotic resistant Enterobacteriaceae: a case report series. Frontiers in immunology, 15, 1359738. https://doi.org/10.3389/fimmu.2024.1359738

Harrison, G. A., Wang, E. R., Cho, K., Mreyoud, Y., Sarkar, S., Almqvist, F., Patti, G. J., & Stallings, C. L. (2024). Inducing vulnerability to InhA inhibition restores isoniazid susceptibility in drug-resistant Mycobacterium tuberculosis. mBio, 15(3), e0296823.

Choy, H. L., Gaylord, E. A., & Doering, T. L. (2024). LAMinar Flow: Sterol Transport in a Pathogenic Yeast. Contact (Thousand Oaks (Ventura County, Calif.)), 7, 25152564241237625. https://doi.org/10.1177/25152564241237625

Pardue, E. J., Sartorio, M. G., Jana, B., Scott, N. E., Beatty, W. L., Ortiz-Marquez, J. C., Van Opijnen, T., Hsu, F. F., Potter, R. F., & Feldman, M. F. (2024). Dual membrane-spanning anti-sigma factors regulate vesiculation in Bacteroides thetaiotaomicron. Proceedings of the National Academy of Sciences of the United States of America, 121(10), e2321910121. https://doi.org/10.1073/pnas.2321910121

Feng, S., McNehlan, M. E., Kinsella, R. L., Sur Chowdhury, C., Chavez, S. M., Naik, S. K., McKee, S. R., Van Winkle, J. A., Dubey, N., Samuels, A., Swain, A., Cui, X., Hendrix, S. V., Woodson, R., Kreamalmeyer, D., Smirnov, A., Artyomov, M. N., Virgin, H. W., Wang, Y. T., & Stallings, C. L. (2024). Autophagy promotes efficient T cell responses to restrict high-dose Mycobacterium tuberculosis infection in mice. Nature microbiology, 10.1038/s41564-024-01608-x. Advance online publication. https://doi.org/10.1038/s41564-024-01608-x

Tuladhar, E. T., Shrestha, S., Vernon, S., Droit, L., Mihindukulasuriya, K. A., Tamang, M., Karki, L., Ngono, A. E., Jha, B., Awal, B. K., Chalise, B. S., Jha, R., Shresta, S., Wang, D., & Manandhar, K. D. (2024). Gemykibivirus detection in acute encephalitis patients from Nepal. medRxiv : the preprint server for health sciences, 2024.02.13.24302648. https://doi.org/10.1101/2024.02.13.24302648

Rosen, A. L., Lint, M. A., Voelker, D. H., Gilbert, N. M., Tomera, C. P., Santiago-Borges, J., Wallace, M. A., Hannan, T. J., Burnham, C.-A. D., Hultgren, S. J., & Kau, A. L. (2024). Secretory leukocyte protease inhibitor protects against severe urinary tract infection in mice. mBio, 15(2), e0255423. https://doi.org/10.1128/mbio.02554-23

Zeng, Q., Antia, A., Casorla-Perez, L. A., Puray-Chavez, M., Kutluay, S. B., Ciorba, M. A., & Ding, S. (2024). Calpain-2 mediates SARS-CoV-2 entry via regulating ACE2 levels. mBio, e0228723. Advance online publication. https://doi.org/10.1128/mbio.02287-23

Li, R., Zan, Y., Wang, D., Chen, X., Wang, A., Tan, H., Zhang, G., Ding, S., Shen, C., Wu, H., & Zhu, S. (2024). A mouse model to distinguish NLRP6-mediated inflammasome-dependent and -independent functions. Proceedings of the National Academy of Sciences of the United States of America, 121(6), e2321419121. https://doi.org/10.1073/pnas.2321419121

Garay, E., Whelan, S. P. J., DuBois, R. M., O’Rourke, S. M., Salgado-Escobar, A. E., Muñoz-Medina, J. E., Arias, C. F., & López, S. (2024). Immune response to SARS-CoV-2 variants after immunization with different vaccines in Mexico. Epidemiology and infection, 152, e30. https://doi.org/10.1017/S0950268824000219

Maddirala, A. R., Tamadonfar, K., Pinkner, J. S., Sanick, D., Hultgren, S. J., & Janetka, J. W. (2024). Discovery of Orally Bioavailable FmlH Lectin Antagonists as Treatment for Urinary Tract Infections. Journal of medicinal chemistry, 10.1021/acs.jmedchem.3c02128. Advance online publication. https://doi.org/10.1021/acs.jmedchem.3c02128

Boodwa-Ko, D., & Doering, T. L. (2024). A Quick reCAP: Discovering Cryptococcus neoformans Capsule Mutants. Journal of fungi (Basel, Switzerland), 10(2), 114. https://doi.org/10.3390/jof10020114

Wu, M., Zheng, W., Song, X., Bao, B., Wang, Y., Ramanan, D., Yang, D., Liu, R., Macbeth, J. C., Do, E. A., Andrade, W. A., Yang, T., Cho, H. S., Gazzaniga, F. S., Ilves, M., Coronado, D., Thompson, C., Hang, S., Chiu, I. M., Moffitt, J. R., … Kasper, D. L. (2024). Gut complement induced by the microbiota combats pathogens and spares commensals. Cell, 187(4), 897–913.e18. https://doi.org/10.1016/j.cell.2023.12.036

Souza, C. E., Jacobson, N. E., An, M. A., Droit, L., Vega, A. A., Rosales, M., Mihindukulasuriya, K. A., Pastrana, K., Handley, S. A., Parkes, M., Rimmer, J., Wang, D., Dinsdale, E. A., A Edwards, R., & Segall, A. M. (2024). Draft genomes of 12 Bifidobacterium isolates from human IBD fecal samples. Microbiology resource announcements, 13(1), e0013023. https://doi.org/10.1128/mra.00130-23

Rinkenberger, N., Rosenberg, A., Radke, J. B., Bhushan, J., Tomita, T., Weiss, L. M., & Sibley, L. D. (2024). Susceptibility of Toxoplasma gondii to autophagy in human cells relies on multiple interacting parasite loci. mBio, 15(1), e0259523. https://doi.org/10.1128/mbio.02595-23

Xu, R., Beatty, W. L., Greigert, V., Witola, W. H., & Sibley, L. D. (2024). Multiple pathways for glucose phosphate transport and utilization support growth of Cryptosporidium parvum. Nature communications, 15(1), 380. https://doi.org/10.1038/s41467-024-44696-3

Whitworth, I. T., Knoener, R. A., Puray-Chavez, M., Halfmann, P., Romero, S., Baddouh, M., Scalf, M., Kawaoka, Y., Kutluay, S. B., Smith, L. M., & Sherer, N. M. (2024). Defining Distinct RNA-Protein Interactomes of SARS-CoV-2 Genomic and Subgenomic RNAs. Journal of proteome research, 23(1), 149–160. https://doi.org/10.1021/acs.jproteome.3c00506

Nye, T. M., Zou, Z., Obernuefemann, C. L. P., Pinkner, J. S., Lowry, E., Kleinschmidt, K., Bergeron, K., Klim, A., Dodson, K. W., Flores-Mireles, A. L., Walker, J. N., Wong, D. G., Desai, A., Caparon, M. G., & Hultgren, S. J. (2024). Microbial co-occurrences on catheters from long-term catheterized patients. Nature communications, 15(1), 61. https://doi.org/10.1038/s41467-023-44095-0

Matta, S. K., Kohio, H. P., Chandra, P., Brown, A., Doench, J. G., Philips, J. A., Ding, S., & Sibley, L. D. (2024). Genome-wide and targeted CRISPR screens identify RNF213 as a mediator of interferon gamma-dependent pathogen restriction in human cells. Proceedings of the National Academy of Sciences of the United States of America, 121(1), e2315865120. https://doi.org/10.1073/pnas.2315865120

Rinkenberger, N., Rosenberg, A., Radke, J. B., Bhushan, J., Tomita, T., Weiss, L. M., & Sibley, L. D. (2024). Susceptibility of Toxoplasma gondii to autophagy in human cells relies on multiple interacting parasite loci. mBio, 15(1), e0259523. https://doi.org/10.1128/mbio.02595-23

Greigert, V., Saraav, I., Son, J., Zhu, Y., Dayao, D., Antia, A., Tzipori, S., Witola, W. H., Stappenbeck, T. S., Ding, S., & Sibley, L. D. (2024). Cryptosporidium infection of human small intestinal epithelial cells induces type III interferon and impairs infectivity of Rotavirus. Gut microbes, 16(1), 2297897. https://doi.org/10.1080/19490976.2023.2297897

Fall 2023

Caparon, M., Xu, W., Bradstreet, T., Zou, Z., Hickerson, S., Zhou, Y., He, H., & Edelson, B. (2023). Reprogramming Short-Chain Fatty Acid Metabolism Mitigates Tissue Damage for Streptococcus pyogenes Necrotizing Skin Infection. Research square, rs.3.rs-3689163. https://doi.org/10.21203/rs.3.rs-3689163/v1

Adams, L. J., VanBlargan, L. A., Liu, Z., Gilchuk, P., Zhao, H., Chen, R. E., Raju, S., Chong, Z., Whitener, B. M., Shrihari, S., Jethva, P. N., Gross, M. L., Crowe, J. E., Jr, Whelan, S. P. J., Diamond, M. S., & Fremont, D. H. (2023). A broadly reactive antibody targeting the N-terminal domain of SARS-CoV-2 spike confers Fc-mediated protection. Cell reports. Medicine, 4(12), 101305. https://doi.org/10.1016/j.xcrm.2023.101305

Achouri, E., Felt, S. A., Hackbart, M., Rivera-Espinal, N. S., & López, C. B. (2023). VODKA2: a fast and accurate method to detect non-standard viral genomes from large RNA-seq data sets. RNA (New York, N.Y.), 30(1), 16–25. https://doi.org/10.1261/rna.079747.123

Heeren, S., Maes, I., Sanders, M., Lye, L. F., Adaui, V., Arevalo, J., Llanos-Cuentas, A., Garcia, L., Lemey, P., Beverley, S. M., Cotton, J. A., Dujardin, J. C., & Van den Broeck, F. (2023). Diversity and dissemination of viruses in pathogenic protozoa. Nature communications, 14(1), 8343. https://doi.org/10.1038/s41467-023-44085-2

Castro, Í. A., Yang, Y., Gnazzo, V., Kim, D. H., Van Dyken, S. J., & López, C. B. (2023). Murine Parainfluenza Virus Persists in Lung Innate Immune Cells Sustaining Chronic Lung Pathology. bioRxiv : the preprint server for biology, 2023.11.07.566103. https://doi.org/10.1101/2023.11.07.566103

González Aparicio, L. J., Yang, Y., Hackbart, M., & López, C. B. (2023). Copy-back viral genomes induce a cellular stress response that interferes with viral protein expression without affecting antiviral immunity. PLoS biology, 21(11), e3002381. https://doi.org/10.1371/journal.pbio.3002381

Berida, T., McKee, S. R., Chatterjee, S., Manning, D. L., Li, W., Pandey, P., Tripathi, S. K., Mreyoud, Y., Smirnov, A., Doerksen, R. J., Jackson, M., Ducho, C., Stallings, C. L., & Roy, S. (2023). Discovery, Synthesis, and Optimization of 1,2,4-Triazolyl Pyridines Targeting Mycobacterium tuberculosis. ACS infectious diseases, 9(11), 2282–2298. https://doi.org/10.1021/acsinfecdis.3c00341

Hackbart, M., & López, C. B. (2023). S RNA Intergenic Deletions Drive Viral Interference during Arenavirus Infections. bioRxiv : the preprint server for biology, 2023.10.31.564889. https://doi.org/10.1101/2023.10.31.564889

McGuffey, J. C., Jackson-Litteken, C. D., Di Venanzio, G., Zimmer, A. A., Lewis, J. M., Distel, J. S., Kim, K. Q., Zaher, H. S., Alfonzo, J., Scott, N. E., & Feldman, M. F. (2023). The tRNA methyltransferase TrmB is critical for Acinetobacter baumannii stress responses and pulmonary infection. mBio, 14(5), e0141623. https://doi.org/10.1128/mbio.01416-23

McAllaster, M. R., Bhushan, J., Balce, D. R., Orvedahl, A., Park, A., Hwang, S., Sullender, M. E., Sibley, L. D., & Virgin, H. W. (2023). Autophagy gene-dependent intracellular immunity triggered by interferon-γ. mBio, 14(6), e0233223. Advance online publication. https://doi.org/10.1128/mbio.02332-23

Agustinho, D. P., Brown, H. L., Chen, G., Gaylord, E. A., Geddes-McAlister, J., Brent, M. R., & Doering, T. L. (2023). Unbiased discovery of natural sequence variants that influence fungal virulence. Cell host & microbe, 31(11), 1910–1920.e5. https://doi.org/10.1016/j.chom.2023.10.002

Serafim, T. D., Iniguez, E., Barletta, A. B. F., Cecilio, P., Doehl, J. S. P., Short, M., Lack, J., Nair, V., Disotuar, M., Wilson, T., Coutinho-Abreu, I. V., Meneses, C., Andersen, J., Alves E Silva, T. L., Oliveira, F., Vega-Rodriguez, J., Barillas-Mury, C., Ribeiro, J. M. C., Beverley, S. M., Kamhawi, S., … Valenzuela, J. G. (2023). Leishmania genetic exchange is mediated by IgM natural antibodies. Nature, 623(7985), 149–156. https://doi.org/10.1038/s41586-023-06655-8

Rosen, A. L., Lint, M. A., Voelker, D. H., Gilbert, N. M., Tomera, C. P., Santiago-Borges, J., Wallace, M. A., Hannan, T. J., Burnham, C. D., Hultgren, S. J., & Kau, A. L. (2023). Secretory Leukocyte Protease Inhibitor Protects Against Severe Urinary Tract Infection in Mice. bioRxiv : the preprint server for biology, 2023.10.10.561753. https://doi.org/10.1101/2023.10.10.561753

Ihedioha, O. C., Sivakoses, A., Beverley, S. M., McMahon-Pratt, D., & Bothwell, A. L. M. (2023). Leishmania major-derived lipophosphoglycan influences the host’s early immune response by inducing platelet activation and DKK1 production via TLR1/2. Frontiers in immunology, 14, 1257046. https://doi.org/10.3389/fimmu.2023.1257046

Naik, S. K., McNehlan, M. E., Mreyoud, Y., Kinsella, R. L., Smirnov, A., Chowdhury, C. S., McKee, S. R., Dubey, N., Woodson, R., Kreamalmeyer, D., & Stallings, C. L. (2023). Type I IFN signaling in the absence of IRGM1 promotes M. tuberculosis replication in immune cells by suppressing T cell responses. bioRxiv : the preprint server for biology, 2023.10.03.560720. https://doi.org/10.1101/2023.10.03.560720

Berna, A. Z., Merriman, J. A., Mellett, L., Parchment, D. K., Caparon, M. G., & Odom John, A. R. (2023). Volatile profiling distinguishes Streptococcus pyogenes from other respiratory streptococcal species. mSphere, 8(5), e0019423. https://doi.org/10.1128/msphere.00194-23

Publications Archive

This page was last updated on October 20th 2023. For changes or additions please email l.stevens@wustl.edu